ENSMUSG00000027360


Mus musculus

Features
Gene ID: ENSMUSG00000027360
  
Biological name :Hdc
  
Synonyms : Hdc / histidine decarboxylase / P23738
  
Possible biological names infered from orthology : P19113
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: F1
Gene start: 126593667
Gene end: 126619299
  
Corresponding Affymetrix probe sets: 10487238 (MoGene1.0st)   1451796_s_at (Mouse Genome 430 2.0 Array)   1454713_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000028838
NCBI entrez gene - 15186     See in Manteia.
MGI - MGI:96062
RefSeq - NM_008230
RefSeq - XM_006498784
RefSeq Peptide - NP_032256
swissprot - P23738
Ensembl - ENSMUSG00000027360
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hdcENSDARG00000075454Danio rerio
 HDCENSGALG00000023436Gallus gallus
 HDCENSG00000140287Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ddc / O88533 / Aromatic-L-amino-acid decarboxylase / P20711* / dopa decarboxylase*ENSMUSG0000002018238
Gadl1 / glutamate decarboxylase like 1 / Q6ZQY3*ENSMUSG0000005688018
Gad1 / P48318 / glutamate decarboxylase 1 / Q99259*ENSMUSG0000007088017
Gad2 / P48320 / glutamic acid decarboxylase 2 / Q05329* / glutamate decarboxylase 2*ENSMUSG0000002678716
Csad / Q9DBE0 / Cysteine sulfinic acid decarboxylase / Q9Y600*ENSMUSG0000002304416


Protein motifs (from Interpro)
Interpro ID Name
 IPR002129  Pyridoxal phosphate-dependent decarboxylase
 IPR010977  Aromatic-L-amino-acid decarboxylase
 IPR015421  Pyridoxal phosphate-dependent transferase, major domain
 IPR015422  Pyridoxal phosphate-dependent transferase domain 1
 IPR015424  Pyridoxal phosphate-dependent transferase
 IPR021115  Pyridoxal-phosphate binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001694 histamine biosynthetic process ISO
 biological_processGO:0006520 cellular amino acid metabolic process IEA
 biological_processGO:0006548 histidine catabolic process IEA
 biological_processGO:0019752 carboxylic acid metabolic process IEA
 biological_processGO:0042423 catecholamine biosynthetic process IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004398 histidine decarboxylase activity TAS
 molecular_functionGO:0016829 lyase activity IEA
 molecular_functionGO:0016831 carboxy-lyase activity IEA
 molecular_functionGO:0030170 pyridoxal phosphate binding IEA


Pathways (from Reactome)
Pathway description
Histidine catabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000005 increased brown fat amount "increased amount of thermogenic tissue in the body that is composed of cells containing multiple small fat droplets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:14208]
Show

Allelic Composition: Keap1tm1Mym/Keap1tm2Mym,Speer6-ps1Tg(Alb-cre)21Mgn/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

 MP:0000008 increased white fat amount "increased quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Keap1tm1Mym/Keap1tm2Mym,Speer6-ps1Tg(Alb-cre)21Mgn/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

 MP:0000336 decreased mast cell number "fewer than expected number of the granulated cells found in most tissues and which contain large amounts of histamine and heparin in granules" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Dhcr7tm1Gst/Dhcr7tm1Gst
Genetic Background: involves: 129P2/OlaHsd

 MP:0000359 abnormal mast cell morphology "anomalous structure of these granulated cells found in most tissues, but most abundantly in skin and g.i. tract" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Dhcr7tm1Gst/Dhcr7tm1Gst
Genetic Background: involves: 129P2/OlaHsd

 MP:0000361 reduced mast cell protease storage "decreased amounts of proteolytic enzymes stored in mast cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Dhcr7tm1Gst/Dhcr7tm1Gst
Genetic Background: involves: 129P2/OlaHsd

 MP:0000362 reduced histamine storage "decreased amounts of this potent vasoactive peptide stored in mast cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Dhcr7tm1Gst/Dhcr7tm1Gst
Genetic Background: involves: 129P2/OlaHsd

 MP:0000836 abnormal substantia nigra morphology "malformation or absence of the layer of gray substance that separates the posterior parts of the cerebral peduncles (tegmentum mesencephali) from the anterior parts; it normally includes a posterior compact part with many pigmented cells (pars compacta) and an anterior reticular part whose cells contain little pigment (pars reticularis)" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Dhcr7tm1Gst/Dhcr7tm1Gst
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Hdctm1Nagy/Hdc+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001261 obese "excessively fat; an increase in fat in the subcutaneous connective tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Keap1tm1Mym/Keap1tm2Mym,Speer6-ps1Tg(Alb-cre)21Mgn/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

 MP:0001363 increased anxiety-related response "when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060]
Show

Allelic Composition: Mapk14tm1Gab/Mapk14tm1Gab
Genetic Background: involves: DBA/1LacJ

 MP:0001417 decreased exploration in new environment "less amount of time spent investigating a new location" [J:79870]
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Allelic Composition: Mapk14tm1Gab/Mapk14tm1Gab
Genetic Background: involves: DBA/1LacJ

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Mapk14tm1Gab/Mapk14tm1Gab
Genetic Background: involves: DBA/1LacJ

 MP:0001906 increased dopamine level "greater than the normal concentration of this catecholamine neurotransmitter, dervied from tyrosine and the precursor to norepinephrine and epinephrine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Dhcr7tm1Gst/Dhcr7tm1Gst
Genetic Background: involves: 129P2/OlaHsd

 MP:0001973 increased thermal nociceptive threshold "a greater than average point at which thermal pain sensation is first detectable" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, J:17194]
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Allelic Composition: Dhcr7tm1Gst/Dhcr7tm1Gst
Genetic Background: involves: 129P2/OlaHsd

 MP:0002063 abnormal learning/memory/conditioning "altered ability to receive, store or recall informational stimuli" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mapk14tm1Gab/Mapk14tm1Gab
Genetic Background: involves: DBA/1LacJ

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Keap1tm1Mym/Keap1tm2Mym,Speer6-ps1Tg(Alb-cre)21Mgn/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
Show

Allelic Composition: Keap1tm1Mym/Keap1tm2Mym,Speer6-ps1Tg(Alb-cre)21Mgn/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

 MP:0002734 abnormal mechanical nociception "abnormal capability to sense pain elicited by mechanical stimulation" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Dhcr7tm1Gst/Dhcr7tm1Gst
Genetic Background: involves: 129P2/OlaHsd

 MP:0002799 abnormal passive avoidance behavior "defects in the ability of an animal to enter an hostile environment where it receives a unpleasant or punishing stimuli applied previously with prolonged latency" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Mapk14tm1Gab/Mapk14tm1Gab
Genetic Background: involves: DBA/1LacJ

 MP:0002945 abnormal inhibitory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an inhibitory impulse arrives at the synapse causing hyperpolarization" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Trpc2tm1Dlc/Trpc2tm1Dlc
Genetic Background: involves: 129S1/Sv

 MP:0004008 abnormal GABA receptor currents "change in the measured amplitude or duration of response to stimulation of GABA receptors" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Gabrg2tm1Wul/Gabrg2tm1Wul,Hdctm1.1(icre)Wwis/Hdc+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0004077 abnormal striatum morphology "malformation of a large cluster of dopaminergic nerve cells, consisting of the caudate nucleus and the putamen, that controls movement, balance, and walking" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Dhcr7tm1Gst/Dhcr7tm1Gst
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Hdctm1Nagy/Hdc+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004811 abnormal neuron physiology "anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings]
Show

Allelic Composition: Gabrg2tm1Wul/Gabrg2tm1Wul,Hdctm1.1(icre)Wwis/Hdc+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Gabbr1tm2Bet/Gabbr1tm2Bet,Hdctm1.1(icre)Wwis/Hdc+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Keap1tm1Mym/Keap1tm2Mym,Speer6-ps1Tg(Alb-cre)21Mgn/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

 MP:0005450 abnormal energy expenditure "utilization of calories that differs from the norm " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Keap1tm1Mym/Keap1tm2Mym,Speer6-ps1Tg(Alb-cre)21Mgn/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

 MP:0005455 increased weight gain "greater increase in body weight over existing weight when compared to the average increase in weight on the same diet, with equal energy (calorie) intake " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:42702]
Show

Allelic Composition: Keap1tm1Mym/Keap1tm2Mym,Speer6-ps1Tg(Alb-cre)21Mgn/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

 MP:0005669 increased circulating leptin level "greater than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
Show

Allelic Composition: Keap1tm1Mym/Keap1tm2Mym,Speer6-ps1Tg(Alb-cre)21Mgn/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

 MP:0008531 increased chemical nociceptive threshold "a greater than average concentration at which chemically induced pain sensation is first detectable" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dhcr7tm1Gst/Dhcr7tm1Gst
Genetic Background: involves: 129P2/OlaHsd

 MP:0009118 increased white fat cell size "increase in the size of fat cells with light coloration and few mitochondria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Keap1tm1Mym/Keap1tm2Mym,Speer6-ps1Tg(Alb-cre)21Mgn/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

 MP:0009142 decreased prepulse inhibition "decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dhcr7tm1Gst/Dhcr7tm1Gst
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Hdctm1Nagy/Hdc+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009288 increased epididymal fat pad weight 
Show

Allelic Composition: Keap1tm1Mym/Keap1tm2Mym,Speer6-ps1Tg(Alb-cre)21Mgn/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

 MP:0009294 increased interscapular fat pad weight 
Show

Allelic Composition: Keap1tm1Mym/Keap1tm2Mym,Speer6-ps1Tg(Alb-cre)21Mgn/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

 MP:0011620 abnormal habituation to a new environment "anomaly in the process in which there is a progressive decline of behavioral response probability with an exposure to a new environment" [MGI:csmith]
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Allelic Composition: Gabbr1tm2Bet/Gabbr1tm2Bet,Hdctm1.1(icre)Wwis/Hdc+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0013894 abnormal behavioral response to amphetamine "anomaly in the behavioral response induced by amphetamine such as induced hyperactivity or stereotypic behavior" [MGI:smb]
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Allelic Composition: Dhcr7tm1Gst/Dhcr7tm1Gst
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Hdctm1Nagy/Hdc+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000027360 Hdc / P23738 / histidine decarboxylase / P19113*  / complex






 

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