ENSG00000140287


Homo sapiens

Features
Gene ID: ENSG00000140287
  
Biological name :HDC
  
Synonyms : HDC / histidine decarboxylase / P19113
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 15
Strand: -1
Band: q21.2
Gene start: 50241947
Gene end: 50266026
  
Corresponding Affymetrix probe sets: 207067_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000267845
Ensembl peptide - ENSP00000440252
Ensembl peptide - ENSP00000453183
NCBI entrez gene - 3067     See in Manteia.
OMIM - 142704
RefSeq - XM_017022099
RefSeq - NM_001306146
RefSeq - NM_002112
RefSeq - XM_017022094
RefSeq - XM_017022095
RefSeq - XM_017022096
RefSeq - XM_017022097
RefSeq Peptide - NP_001293075
RefSeq Peptide - NP_002103
swissprot - P19113
swissprot - H0YLF0
Ensembl - ENSG00000140287
  
Related genetic diseases (OMIM): 137580 - {Gilles de la Tourette syndrome, susceptibility to}, 137580
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hdcENSDARG00000075454Danio rerio
 HDCENSGALG00000023436Gallus gallus
 HdcENSMUSG00000027360Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DDC / P20711 / dopa decarboxylaseENSG0000013243737
GAD1 / Q99259 / glutamate decarboxylase 1ENSG0000012868318
GADL1 / Q6ZQY3 / glutamate decarboxylase like 1ENSG0000014464417
GAD2 / Q05329 / glutamate decarboxylase 2ENSG0000013675016
CSAD / Q9Y600 / cysteine sulfinic acid decarboxylaseENSG0000013963116


Protein motifs (from Interpro)
Interpro ID Name
 IPR002129  Pyridoxal phosphate-dependent decarboxylase
 IPR010977  Aromatic-L-amino-acid decarboxylase
 IPR015421  Pyridoxal phosphate-dependent transferase, major domain
 IPR015422  Pyridoxal phosphate-dependent transferase domain 1
 IPR015424  Pyridoxal phosphate-dependent transferase
 IPR021115  Pyridoxal-phosphate binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001694 histamine biosynthetic process TAS
 biological_processGO:0006520 cellular amino acid metabolic process IEA
 biological_processGO:0006547 histidine metabolic process TAS
 biological_processGO:0006548 histidine catabolic process IDA
 biological_processGO:0019752 carboxylic acid metabolic process IEA
 biological_processGO:0042423 catecholamine biosynthetic process IEA
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004398 histidine decarboxylase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016829 lyase activity IEA
 molecular_functionGO:0016831 carboxy-lyase activity IEA
 molecular_functionGO:0030170 pyridoxal phosphate binding IEA


Pathways (from Reactome)
Pathway description
Histidine catabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000140287 HDC / P19113 / histidine decarboxylase  / complex






 

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