ENSG00000136750


Homo sapiens

Features
Gene ID: ENSG00000136750
  
Biological name :GAD2
  
Synonyms : GAD2 / glutamate decarboxylase 2 / Q05329
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 10
Strand: 1
Band: p12.1
Gene start: 26216307
Gene end: 26304558
  
Corresponding Affymetrix probe sets: 1568601_at (Human Genome U133 Plus 2.0 Array)   206780_at (Human Genome U133 Plus 2.0 Array)   211264_at (Human Genome U133 Plus 2.0 Array)   216651_s_at (Human Genome U133 Plus 2.0 Array)   243265_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000259271
Ensembl peptide - ENSP00000365424
Ensembl peptide - ENSP00000365437
Ensembl peptide - ENSP00000390434
NCBI entrez gene - 2572     See in Manteia.
OMIM - 138275
RefSeq - NM_001134366
RefSeq - NM_000818
RefSeq Peptide - NP_000809
RefSeq Peptide - NP_001127838
swissprot - Q05329
swissprot - Q5VZ29
swissprot - Q5VZ30
swissprot - Q5VZ31
Ensembl - ENSG00000136750
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gad2ENSDARG00000015537Danio rerio
 GAD2ENSGALG00000040436Gallus gallus
 Gad2ENSMUSG00000026787Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GAD1 / Q99259 / glutamate decarboxylase 1ENSG0000012868365
CSAD / Q9Y600 / cysteine sulfinic acid decarboxylaseENSG0000013963144
GADL1 / Q6ZQY3 / glutamate decarboxylase like 1ENSG0000014464441
HDC / P19113 / histidine decarboxylaseENSG0000014028718
DDC / P20711 / dopa decarboxylaseENSG0000013243718


Protein motifs (from Interpro)
Interpro ID Name
 IPR002129  Pyridoxal phosphate-dependent decarboxylase
 IPR015421  Pyridoxal phosphate-dependent transferase, major domain
 IPR015422  Pyridoxal phosphate-dependent transferase domain 1
 IPR015424  Pyridoxal phosphate-dependent transferase
 IPR021115  Pyridoxal-phosphate binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006540 glutamate decarboxylation to succinate TAS
 biological_processGO:0007268 chemical synaptic transmission TAS
 biological_processGO:0007269 neurotransmitter secretion TAS
 biological_processGO:0019752 carboxylic acid metabolic process IEA
 biological_processGO:0042136 neurotransmitter biosynthetic process IEA
 biological_processGO:0042493 response to drug IEA
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0030672 synaptic vesicle membrane IEA
 cellular_componentGO:0031225 anchored component of membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0042734 presynaptic membrane IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0060077 inhibitory synapse IEA
 cellular_componentGO:0061202 clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane TAS
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004351 glutamate decarboxylase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016595 glutamate binding IEA
 molecular_functionGO:0016829 lyase activity IEA
 molecular_functionGO:0016831 carboxy-lyase activity IEA
 molecular_functionGO:0030170 pyridoxal phosphate binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
GABA synthesis
GABA synthesis, release, reuptake and degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000128683 GAD1 / Q99259 / glutamate decarboxylase 1  / complex
 ENSG00000136750 GAD2 / Q05329 / glutamate decarboxylase 2  / complex






 

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