ENSDARG00000030490


Danio rerio

Features
Gene ID: ENSDARG00000030490
  
Biological name :sptb
  
Synonyms : spectrin, beta, erythrocytic / sptb
  
Possible biological names infered from orthology : P11277
  
Species: Danio rerio
  
Chr. number: 17
Strand: 1
Band:
Gene start: 38566717
Gene end: 38599022
  
Corresponding Affymetrix probe sets: Dr.10652.1.S1_at (Zebrafish Array)   NM_131525_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000040626
Ensembl peptide - ENSDARP00000113965
NCBI entrez gene - 58040     See in Manteia.
RefSeq - NM_131525
RefSeq - XM_005158850
RefSeq - XM_005158851
RefSeq Peptide - NP_571600
swissprot - F1QQE5
ZFIN ID - ZDB-GENE-000906-1
Ensembl - ENSDARG00000030490
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SPTBENSGALG00000036805Gallus gallus
 SPTBENSG00000070182Homo sapiens
 SptbENSMUSG00000021061Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
sptbn1 / spectrin, beta, non-erythrocytic 1 / Q01082* / Q62261* / Spectrin beta chain, non-erythrocytic 1 *ENSDARG0000010288357
sptbn2 / spectrin, beta, non-erythrocytic 2 / O15020*ENSDARG0000005395656
SPTBN4 / si:ch73-262h23.4 / Q9H254* / spectrin beta, non-erythrocytic 4*ENSDARG0000009262429
sptbn5 / spectrin, beta, non-erythrocytic 5 / Q9NRC6*ENSDARG0000009768327
sptan1 / spectrin alpha, non-erythrocytic 1 / SPTA1* / Q13813* / P08032* / P16546* / P02549* / spectrin alpha, erythrocytic 1* / Spectrin alpha chain, erythrocytic 1 * / Spectrin alpha chai...ENSDARG0000001923122
si:dkey-27p18.5 / Q9H254* / SPTBN4* / spectrin beta, non-erythrocytic 4*ENSDARG0000006862416
actn3a / actinin alpha 3a / ACTN3* / Q08043* / O88990* / Alpha-actinin-3 * / actinin alpha 3 (gene/pseudogene)*ENSDARG0000001375511
actn3b / actinin alpha 3b / ACTN3* / Q08043* / O88990* / Alpha-actinin-3 * / actinin alpha 3 (gene/pseudogene)*ENSDARG0000000143111
actn2b / actinin, alpha 2b / ACTN2* / P35609* / Q9JI91* / actinin alpha 2* / Alpha-actinin-2 *ENSDARG0000007109011
actn4 / actinin, alpha 4 / O43707*ENSDARG0000009978611
actn1 / actinin, alpha 1 / P12814* / Q7TPR4* / Mus musculus actinin, alpha 1 (Actn1), transcript variant 2, mRNA.*ENSDARG0000000721911
si:ch73-262h23.4 / Q9H254* / SPTBN4* / spectrin beta, non-erythrocytic 4*ENSDARG000001119428
si:zfos-1837d3.1 / Q62261* / Q01082* / SPTBN1* / spectrin beta, non-erythrocytic 1* / Spectrin beta chain, non-erythrocytic 1 *ENSDARG000001054283


Protein motifs (from Interpro)
Interpro ID Name
 IPR001589  Actinin-type actin-binding domain, conserved site
 IPR001605  Pleckstrin homology domain, spectrin-type
 IPR001715  Calponin homology domain
 IPR001849  Pleckstrin homology domain
 IPR002017  Spectrin repeat
 IPR011993  PH-like domain superfamily
 IPR016343  Spectrin, beta subunit
 IPR018159  Spectrin/alpha-actinin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007010 cytoskeleton organization IEA
 biological_processGO:0035162 embryonic hemopoiesis IMP
 biological_processGO:0048821 erythrocyte development IMP
 biological_processGO:0051693 actin filament capping IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0008091 spectrin IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005200 structural constituent of cytoskeleton IEA
 molecular_functionGO:0005543 phospholipid binding IEA


Pathways (from Reactome)
Pathway description
NCAM signaling for neurite out-growth
Interaction between L1 and Ankyrins
RAF/MAP kinase cascade
COPI-mediated anterograde transport


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000007 blood blood quality , abnormal
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 ZFA:0000009 cardiac ventricle cardiac ventricle dilated , abnormal
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 ZFA:0000471 atrium atrium dilated , abnormal
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 ZFA:0000529 kidney kidney increased size , abnormal
kidney hyperplastic , abnormal
kidney has extra parts of type erythroid progenitor cell , abnormal
Show

 ZFA:0001439 anatomical system anatomical system quality , abnormal
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 ZFA:0009256 nucleate erythrocyte nucleate erythrocyte shape , abnormal
nucleate erythrocyte binucleate , abnormal
nucleate erythrocyte absent , abnormal
nucleate erythrocyte spherical , abnormal
nucleate erythrocyte decreased amount , abnormal
nucleate erythrocyte teardrop-shaped , abnormal
nucleate erythrocyte nucleus structure , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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