ENSDARG00000041107


Danio rerio

Features
Gene ID: ENSDARG00000041107
  
Biological name :cftr
  
Synonyms : cftr / cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) / Q1LX78
  
Possible biological names infered from orthology : cystic fibrosis transmembrane conductance regulator / P13569 / P26361
  
Species: Danio rerio
  
Chr. number: 18
Strand: 1
Band:
Gene start: 20677090
Gene end: 20722810
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000060242
NCBI entrez gene - 559080     See in Manteia.
RefSeq - NM_001044883
RefSeq Peptide - NP_001038348
swissprot - Q1LX78
ZFIN ID - ZDB-GENE-050517-20
Ensembl - ENSDARG00000041107
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CFTRENSGALG00000032986Gallus gallus
 CFTRENSG00000001626Homo sapiens
 CftrENSMUSG00000041301Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
abcc4 / ATP-binding cassette, sub-family C (CFTR/MRP), member 4 / O15439* / ATP binding cassette subfamily C member 4*ENSDARG0000005895328
abcc1 / ATP-binding cassette, sub-family C (CFTR/MRP), member 1 / O35379* / P33527* / ATP binding cassette subfamily C member 1*ENSDARG0000010471925
abcc2 / ATP-binding cassette, sub-family C (CFTR/MRP), member 2 / Q92887* / Q8VI47* / ATP binding cassette subfamily C member 2* / Canalicular multispecific organic anion transporter 1 *ENSDARG0000001403125
abcc3 / ATP-binding cassette, sub-family C (CFTR/MRP), member 3 / O15438* / ATP binding cassette subfamily C member 3*ENSDARG0000009666225
abcc6a / ATP-binding cassette, sub-family C (CFTR/MRP), member 6aENSDARG0000001675024
abcc6b.2 / ATP-binding cassette, sub-family C (CFTR/MRP), member 6b, tandem duplicate 2ENSDARG0000009490124
abcc12 / ATP-binding cassette, sub-family C (CFTR/MRP), member 12 / Q96J66* / Q80WJ6* / Q96J65* / ABCC11* / ATP binding cassette subfamily C member 12* / ATP binding cassette subfamily C me...ENSDARG0000001305023
abcc10 / ATP-binding cassette, sub-family C (CFTR/MRP), member 10ENSDARG0000007798823
abcc8b / ATP-binding cassette, sub-family C (CFTR/MRP), member 8b / ABCC8* / Q09428* / ATP binding cassette subfamily C member 8*ENSDARG0000007700722
si:ch211-221f10.2ENSDARG0000007654722
abcc5 / ATP-binding cassette, sub-family C (CFTR/MRP), member 5 / O15440* / Q9R1X5* / ATP binding cassette subfamily C member 5* / Multidrug resistance-associated protein 5 *ENSDARG0000006123322
abcc8 / ATP-binding cassette, sub-family C (CFTR/MRP), member 8 / Q09428* / ATP binding cassette subfamily C member 8*ENSDARG0000005187921
abcc9 / ATP-binding cassette, sub-family C (CFTR/MRP), member 9 / O60706* / P70170* / ATP binding cassette subfamily C member 9*ENSDARG0000001598521
abcc6b.1 / ATP-binding cassette, sub-family C (CFTR/MRP), member 6b, tandem duplicate 1ENSDARG0000010540318


Protein motifs (from Interpro)
Interpro ID Name
 IPR003439  ABC transporter-like
 IPR003593  AAA+ ATPase domain
 IPR009147  Cystic fibrosis transmembrane conductance regulator
 IPR011527  ABC transporter type 1, transmembrane domain
 IPR017871  ABC transporter, conserved site
 IPR025837  CFTR regulator domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002679 respiratory burst involved in defense response IMP
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006821 chloride transport IEA
 biological_processGO:0015701 bicarbonate transport ISS
 biological_processGO:0031016 pancreas development IMP
 biological_processGO:0035377 transepithelial water transport ISS
 biological_processGO:0042742 defense response to bacterium IMP
 biological_processGO:0050891 multicellular organismal water homeostasis ISS
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0070121 Kupffer"s vesicle development IMP
 biological_processGO:0090022 regulation of neutrophil chemotaxis IMP
 biological_processGO:1902476 chloride transmembrane transport ISS
 biological_processGO:1904322 cellular response to forskolin ISS
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane ISS
 cellular_componentGO:0005829 cytosol IBA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane ISS
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0031901 early endosome membrane IEA
 cellular_componentGO:0034707 chloride channel complex IEA
 cellular_componentGO:0055038 recycling endosome membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005254 chloride channel activity ISS
 molecular_functionGO:0005260 intracellularly ATP-gated chloride channel activity IBA
 molecular_functionGO:0005524 ATP binding IDA
 molecular_functionGO:0015106 bicarbonate transmembrane transporter activity ISS
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016887 ATPase activity ISS
 molecular_functionGO:0042626 ATPase activity, coupled to transmembrane movement of substances IBA


Pathways (from Reactome)
Pathway description
ABC-family proteins mediated transport
RHO GTPases regulate CFTR trafficking
Ub-specific processing proteases
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000001 Kupffer s vesicle Kupffers vesicle decreased volume , abnormal
Kupffers vesicle unlumenized , abnormal
Kupffers vesicle absent , abnormal
Show

 ZFA:0000008 brain brain spatial pattern , abnormal
brain right side mislocalised , abnormal
Show

 ZFA:0000114 heart heart mislocalised , abnormal
Show

 ZFA:0000123 liver liver mislocalised , abnormal
Show

 ZFA:0000140 pancreas pancreas morphology , abnormal
pancreas decreased size , abnormal
pancreas degenerate , abnormal
pancreas lacks parts or has fewer parts of type pancreatic acinar cell , abnormal
pancreas neutrophil mislocalised , abnormal
Show

 ZFA:0001249 exocrine pancreas exocrine pancreas degenerate , abnormal
exocrine pancreas fibrillary , abnormal
exocrine pancreas central region lacks all parts of type pancreatic acinar cell , abnormal
Show

 ZFA:0001372 pancreatic duct pancreatic duct obstructed , abnormal
pancreatic duct dilated , abnormal
Show

 ZFA:0005739 pancreatic acinar cell pancreatic acinar cell decreased amount , abnormal
Show

 ZFA:0005740 pancreatic centroacinar cell pancreatic centroacinar cell decreased amount , abnormal
Show

 ZFA:0005755 islet islet increased amount , abnormal
islet decreased size , abnormal
islet disorganized , abnormal
Show

 ZFA:0005756 secondary islet secondary islet cell decreased amount , abnormal
Show

 ZFA:0009327 neutrophil neutrophil decreased amount , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000025953 rhoq / ras homolog family member Q / P17081* / Q8R527* / Rho-related GTP-binding protein RhoQ *  / reaction / complex
 ENSDARG00000023117 gopc / golgi-associated PDZ and coiled-coil motif containing / Q8BH60* / Q9HD26* / AL132671.2*  / complex
 ENSDARG00000041107 cftr / Q1LX78 / cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) / P13569* / P26361* / cystic fibrosis transmembrane conductance regulator*  / complex
 ENSDARG00000103422 usp10 / ubiquitin specific peptidase 10 / P52479* / Q14694*  / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr