ENSDARG00000067626


Danio rerio

Features
Gene ID: ENSDARG00000067626
  
Biological name :ywhag1
  
Synonyms : 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 1 / Q6PC29 / ywhag1
  
Possible biological names infered from orthology : P61981 / P61982 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide / YWHAG
  
Species: Danio rerio
  
Chr. number: 5
Strand: 1
Band:
Gene start: 3501859
Gene end: 3545221
  
Corresponding Affymetrix probe sets: Dr.11266.1.S1_at (Zebrafish Array)   Dr.11266.2.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000074935
NCBI entrez gene - 117604     See in Manteia.
swissprot - A1E267
swissprot - Q6PC29
ZFIN ID - ZDB-GENE-011115-1
Ensembl - ENSDARG00000067626
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 YWHAGENSGALG00000017358Gallus gallus
 YWHAGENSG00000170027Homo sapiens
 YwhagENSMUSG00000051391Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ywhag2 / 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 2 / YWHAG* / P61982* / P61981* / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation pro...ENSDARG0000007165898
ywhah / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide / P68510* / Q04917* / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta*ENSDARG0000000556084
ywhaba / Q5PRD0 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide a / YWHAB* / P31946* / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activat...ENSDARG0000001307875
ywhabb / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide b / YWHAB* / Q9CQV8* / P31946* / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activa...ENSDARG0000007575874
ywhabl / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide likeENSDARG0000004028772
ywhaqa / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide a / SFN* / YWHAQ* / P27348* / P31947* / P68254* / O70456* / stratifin* / tyrosine 3-monoox...ENSDARG0000004253971
ywhaz / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptideENSDARG0000003257570
ywhaqb / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide b / SFN* / YWHAQ* / P27348* / P31947* / P68254* / O70456* / stratifin* / tyrosine 3-monoox...ENSDARG0000002332370
ywhae2 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 2ENSDARG0000001701462
ywhae1 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 1 / YWHAE* / P62259* / P62258* / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase act...ENSDARG0000000639962


Protein motifs (from Interpro)
Interpro ID Name
 IPR000308  14-3-3 protein
 IPR023409  14-3-3 protein, conserved site
 IPR023410  14-3-3 domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007420 brain development IMP
 biological_processGO:0007507 heart development IMP
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0019904 protein domain specific binding IEA


Pathways (from Reactome)
Pathway description
Activation of BAD and translocation to mitochondria
Translocation of SLC2A4 (GLUT4) to the plasma membrane
Regulation of PLK1 Activity at G2/M Transition
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Anchoring of the basal body to the plasma membrane
TP53 Regulates Metabolic Genes
AURKA Activation by TPX2


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain malformed , abnormal
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 ZFA:0000009 cardiac ventricle cardiac ventricle increased diameter , abnormal
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 ZFA:0000360 heart tube heart tube increased size , abnormal
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 ZFA:0001114 head head hypoplastic , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000067626 ywhag1 / Q6PC29 / 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 1 / YWHAG* / P61982* / P61981* / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activ...  / complex
 ENSDARG00000071658 ywhag2 / 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 2 / YWHAG* / P61982* / P61981* / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation pro...  / complex






 

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