ENSDARG00000102277


Danio rerio

Features
Gene ID: ENSDARG00000102277
  
Biological name :lama1
  
Synonyms : lama1 / laminin, alpha 1
  
Possible biological names infered from orthology : laminin subunit alpha 1 / P25391
  
Species: Danio rerio
  
Chr. number: 24
Strand: 1
Band:
Gene start: 41690545
Gene end: 41784173
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000135371
NCBI entrez gene - 569971     See in Manteia.
RefSeq - NM_001034986
RefSeq Peptide - NP_001030158
swissprot - A0A0R4II20
ZFIN ID - ZDB-GENE-060118-1
Ensembl - ENSDARG00000102277
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 LAMA1ENSGALG00000014615Gallus gallus
 LAMA1ENSG00000101680Homo sapiens
 Lama1ENSMUSG00000032796Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
lama5 / laminin, alpha 5 / O15230* / Q61001* / laminin subunit alpha 5*ENSDARG0000005854327
lama2 / laminin, alpha 2 / P24043* / laminin subunit alpha 2*ENSDARG0000009939013
lamb2 / laminin, beta 2 (laminin S) / P55268* / Q61292* / laminin subunit beta 2*ENSDARG0000000208413
lamb2l / laminin, beta 2-likeENSDARG0000003395012
lama3 / laminin, alpha 3 / Q16787* / Q61789* / laminin subunit alpha 3* / Mus musculus laminin, alpha 3 (Lama3), transcript variant 2, mRNA.*ENSDARG0000007146212
lamc1 / Q1LVF0 / laminin, gamma 1 / P11047* / laminin subunit gamma 1*ENSDARG0000003627912
lamb1b / laminin, beta 1b / LAMB1* / P02469* / P07942* / laminin subunit beta 1*ENSDARG0000004552412
CABZ01065423.1 / LAMA2* / P24043* / laminin subunit alpha 2*ENSDARG0000011201912
lama4 / laminin, alpha 4 / P97927* / Q16363* / laminin subunit alpha 4*ENSDARG0000002078512
lamb1a / laminin, beta 1a / LAMB1* / P02469* / P07942* / laminin subunit beta 1*ENSDARG0000010120911
lamc3 / laminin, gamma 3 / Q9R0B6* / Q9Y6N6* / laminin subunit gamma 3*ENSDARG0000009357211
CABZ01092781.1 / LAMB3* / Q13751* / laminin subunit beta 3*ENSDARG0000011004011
lamb4 / laminin, beta 4 / A4D0S4* / laminin subunit beta 4*ENSDARG0000003913311
si:ch211-241e1.3 / LAMA3* / Q16787* / Q61789* / laminin subunit alpha 3* / Mus musculus laminin, alpha 3 (Lama3), transcript variant 2, mRNA.*ENSDARG000000226159
si:dkey-202e22.2ENSDARG000000612604
ntn4 / netrin 4 / Q9HB63* / Q9JI33*ENSDARG000001020664
lamc2 / laminin, gamma 2 / Q13753* / laminin subunit gamma 2*ENSDARG000000682884


Protein motifs (from Interpro)
Interpro ID Name
 IPR000034  Laminin IV
 IPR000742  EGF-like domain
 IPR001791  Laminin G domain
 IPR002049  Laminin EGF domain
 IPR008211  Laminin, N-terminal
 IPR008979  Galactose-binding-like domain superfamily
 IPR009254  Laminin alpha, domain I
 IPR010307  Laminin domain II
 IPR013032  EGF-like, conserved site
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001568 blood vessel development IGI
 biological_processGO:0001654 eye development IMP
 biological_processGO:0001764 neuron migration IMP
 biological_processGO:0002088 lens development in camera-type eye IMP
 biological_processGO:0003412 establishment of epithelial cell apical/basal polarity involved in camera-type eye morphogenesis IMP
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007409 axonogenesis IMP
 biological_processGO:0007411 axon guidance IMP
 biological_processGO:0007420 brain development IMP
 biological_processGO:0007634 optokinetic behavior IMP
 biological_processGO:0008045 motor neuron axon guidance IMP
 biological_processGO:0030155 regulation of cell adhesion IEA
 biological_processGO:0030334 regulation of cell migration IEA
 biological_processGO:0030903 notochord development IMP
 biological_processGO:0031290 retinal ganglion cell axon guidance IMP
 biological_processGO:0043010 camera-type eye development IMP
 biological_processGO:0045995 regulation of embryonic development IEA
 biological_processGO:0048514 blood vessel morphogenesis IGI
 biological_processGO:0048593 camera-type eye morphogenesis IMP
 biological_processGO:0048854 brain morphogenesis IMP
 biological_processGO:0060034 notochord cell differentiation IMP
 biological_processGO:0060035 notochord cell development IMP
 biological_processGO:0061053 somite development IMP
 biological_processGO:0061303 cornea development in camera-type eye IMP
 molecular_functionGO:0005102 signaling receptor binding IEA


Pathways (from Reactome)
Pathway description
Laminin interactions
MET activates PTK2 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain quality , abnormal
brain morphology , abnormal
brain surface feature shape , abnormal
brain disorganized , abnormal
brain hydrocephalic , abnormal
brain shape , abnormal
Show

 ZFA:0000012 central nervous system central nervous system hemorrhagic , abnormal
central nervous system morphology , abnormal
Show

 ZFA:0000024 retinal ganglion cell layer retinal ganglion cell layer dispersed , abnormal
Show

 ZFA:0000029 hindbrain hindbrain quality , abnormal
hindbrain morphology , abnormal
Show

 ZFA:0000035 lens lens ovate , abnormal
lens quality , abnormal
lens degenerate , abnormal
lens morphology , abnormal
lens protruding out of eye , abnormal
lens collagen fibril organization disrupted , abnormal
lens aplastic , abnormal
lens absent , abnormal
lens mislocalised , abnormal
lens cell death increased occurrence , abnormal
Show

 ZFA:0000050 optic vesicle optic vesicle absent , abnormal
Show

 ZFA:0000064 presumptive retinal pigmented epithelium presumptive retinal pigmented epithelium flattened , abnormal
Show

 ZFA:0000107 eye eye quality , abnormal
eye hemorrhagic , abnormal
eye morphology , abnormal
eye decreased size , abnormal
eye mislocalised ventrally , abnormal
eye lacks all parts of type lens , abnormal
Show

 ZFA:0000110 fourth ventricle fourth ventricle increased size , abnormal
Show

 ZFA:0000135 notochord notochord undulate , abnormal
notochord undifferentiated , abnormal
notochord poorly differentiated , abnormal
notochord quality , abnormal
notochord morphology , abnormal
notochord structure , abnormal
notochord cell structure , abnormal
notochord anterior region undifferentiated , abnormal
Show

 ZFA:0000137 optic stalk optic stalk increased diameter , abnormal
Show

 ZFA:0000155 somite somite quality , abnormal
somite condensed , abnormal
somite morphology , abnormal
somite U-shaped , abnormal
Show

 ZFA:0000206 facial nerve motor nucleus facial nerve motor nucleus motor neuron mislocalised , abnormal
Show

 ZFA:0000282 sensory system sensory system quality , abnormal
Show

 ZFA:0000318 brainstem and spinal white matter brainstem and spinal white matter axon decreased amount , abnormal
Show

 ZFA:0000396 nervous system nervous system quality , abnormal
Show

 ZFA:0000435 cranial nerve II cranial nerve II morphology , abnormal
Show

 ZFA:0000543 medial longitudinal fasciculus medial longitudinal fasciculus morphology , abnormal
medial longitudinal fasciculus axon branched , abnormal
Show

 ZFA:0000610 vertical myoseptum vertical myoseptum morphology , abnormal
Show

 ZFA:0000640 cornea cornea increased thickness , abnormal
Show

 ZFA:0001071 presumptive neural retina presumptive neural retina flattened , abnormal
presumptive neural retina cell decreased length , abnormal
Show

 ZFA:0001094 whole organism whole organism shape , abnormal
whole organism decreased length , abnormal
whole organism lethal (sensu genetics) , abnormal
whole organism viability , abnormal
whole organism increased curvature , abnormal
whole organism malformed , abnormal
whole organism dead , abnormal
whole organism decreased life span , abnormal
whole organism curved dorsal , abnormal
Show

 ZFA:0001117 post-vent region post-vent region curved dorsal , abnormal
post-vent region curved , abnormal
Show

 ZFA:0001202 optic cup optic cup anterior margin increased amount , abnormal
optic cup focal adhesion increased amount , abnormal
optic cup apoptotic process increased occurrence , abnormal
optic cup basal lamina spatial pattern , abnormal
optic cup basal lamina mislocalised , abnormal
Show

 ZFA:0001283 pupil pupil irregularly shaped , abnormal
pupil decreased size , abnormal
Show

 ZFA:0001284 optic fissure optic fissure closure incomplete , abnormal
optic fissure focal adhesion decreased amount , abnormal
Show

 ZFA:0001285 intersegmental vessel intersegmental vessel morphology , abnormal
intersegmental vessel decreased length , abnormal
intersegmental vessel aplastic , abnormal
Show

 ZFA:0001367 forebrain midbrain boundary forebrain midbrain boundary increased width , abnormal
Show

 ZFA:0005491 optic furrow optic furrow malformed , abnormal
Show

 ZFA:0009310 retinal ganglion cell retinal ganglion cell poorly differentiated , abnormal
retinal ganglion cell axon misrouted , abnormal
retinal ganglion cell axon disorganized , abnormal
retinal ganglion cell axon ipsilateral to eye , abnormal
retinal ganglion cell axon displaced to telencephalon , abnormal
retinal ganglion cell cell body mislocalised , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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