ENSG00000004700


Homo sapiens

Features
Gene ID: ENSG00000004700
  
Biological name :RECQL
  
Synonyms : P46063 / RECQL / RecQ like helicase
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: -1
Band: p12.1
Gene start: 21468911
Gene end: 21501669
  
Corresponding Affymetrix probe sets: 205091_x_at (Human Genome U133 Plus 2.0 Array)   210568_s_at (Human Genome U133 Plus 2.0 Array)   212917_x_at (Human Genome U133 Plus 2.0 Array)   212918_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000445555
Ensembl peptide - ENSP00000440700
Ensembl peptide - ENSP00000446036
Ensembl peptide - ENSP00000318727
Ensembl peptide - ENSP00000379400
Ensembl peptide - ENSP00000395449
Ensembl peptide - ENSP00000416739
Ensembl peptide - ENSP00000439069
NCBI entrez gene - 5965     See in Manteia.
OMIM - 600537
RefSeq - XM_005253464
RefSeq - NM_002907
RefSeq - NM_032941
RefSeq - XM_005253461
RefSeq - XM_005253462
RefSeq - XM_005253463
RefSeq Peptide - NP_116559
RefSeq Peptide - NP_002898
swissprot - A0A024RAV2
swissprot - F5GYB7
swissprot - F5H2L2
swissprot - F5H3W0
swissprot - F5H4P4
swissprot - F8WD97
swissprot - F8WA66
swissprot - P46063
Ensembl - ENSG00000004700
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 recqlENSDARG00000007175Danio rerio
 RECQLENSGALG00000013174Gallus gallus
 RecqlENSMUSG00000030243Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
BLM / P54132 / Bloom syndrome RecQ like helicaseENSG0000019729936
O94762 / RECQL5 / RecQ like helicase 5ENSG0000010846927
WRN / Q14191 / Werner syndrome RecQ like helicaseENSG0000016539226
RECQL4 / RecQ like helicase 4ENSG0000016095720


Protein motifs (from Interpro)
Interpro ID Name
 IPR001650  Helicase, C-terminal
 IPR004589  DNA helicase, ATP-dependent, RecQ type
 IPR011545  DEAD/DEAH box helicase domain
 IPR014001  Helicase superfamily 1/2, ATP-binding domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR032284  ATP-dependent DNA helicase RecQ, zinc-binding domain
 IPR036388  Winged helix-like DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000724 double-strand break repair via homologous recombination IBA
 biological_processGO:0000733 DNA strand renaturation IDA
 biological_processGO:0006281 DNA repair TAS
 biological_processGO:0006310 DNA recombination IEA
 biological_processGO:0032508 DNA duplex unwinding IEA
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005694 chromosome IBA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0016020 membrane HDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IBA
 molecular_functionGO:0003678 DNA helicase activity TAS
 molecular_functionGO:0004003 ATP-dependent DNA helicase activity TAS
 molecular_functionGO:0004386 helicase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008026 ATP-dependent helicase activity IEA
 molecular_functionGO:0009378 four-way junction helicase activity IBA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0036310 annealing helicase activity IDA
 molecular_functionGO:0043140 ATP-dependent 3"-5" DNA helicase activity IBA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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