ENSG00000067048


Homo sapiens

Features
Gene ID: ENSG00000067048
  
Biological name :DDX3Y
  
Synonyms : DDX3Y / DEAD-box helicase 3, Y-linked / O15523
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: Y
Strand: 1
Band: q11.221
Gene start: 12904108
Gene end: 12920478
  
Corresponding Affymetrix probe sets: 1570359_at (Human Genome U133 Plus 2.0 Array)   1570360_s_at (Human Genome U133 Plus 2.0 Array)   205000_at (Human Genome U133 Plus 2.0 Array)   205001_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000353284
Ensembl peptide - ENSP00000400377
Ensembl peptide - ENSP00000398953
Ensembl peptide - ENSP00000336725
NCBI entrez gene - 8653     See in Manteia.
OMIM - 400010
RefSeq - NM_001122665
RefSeq - NM_001302552
RefSeq - NM_001324195
RefSeq - NM_004660
RefSeq Peptide - NP_001311124
RefSeq Peptide - NP_004651
RefSeq Peptide - NP_001116137
RefSeq Peptide - NP_001289481
swissprot - A0A024R9A4
swissprot - C9J8G5
swissprot - O15523
swissprot - C9J081
Ensembl - ENSG00000067048
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ddx3aENSDARG00000020573Danio rerio
 ddx3bENSDARG00000005774Danio rerio
 DDX3XENSGALG00000016231Gallus gallus
 Ddx3yENSMUSG00000069045Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DDX3X / O00571 / DEAD-box helicase 3, X-linkedENSG0000021530193
DDX4 / Q9NQI0 / DEAD-box helicase 4ENSG0000015267044
DDX41 / Q9UJV9 / DEAD-box helicase 41ENSG0000018325829
DDX59 / Q5T1V6 / DEAD-box helicase 59ENSG0000011819725
DDX1 / Q92499 / DEAD-box helicase 1ENSG0000007978521


Protein motifs (from Interpro)
Interpro ID Name
 IPR000629  ATP-dependent RNA helicase DEAD-box, conserved site
 IPR001650  Helicase, C-terminal
 IPR011545  DEAD/DEAH box helicase domain
 IPR014001  Helicase superfamily 1/2, ATP-binding domain
 IPR014014  RNA helicase, DEAD-box type, Q motif
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006413 translational initiation IBA
 biological_processGO:0007059 chromosome segregation IBA
 biological_processGO:0010468 regulation of gene expression IBA
 biological_processGO:0010501 RNA secondary structure unwinding IBA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005730 nucleolus IBA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0036464 cytoplasmic ribonucleoprotein granule IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0004004 ATP-dependent RNA helicase activity IBA
 molecular_functionGO:0004386 helicase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000027 Azoospermia 
Show

 HP:0000028 Cryptorchidism "Absence of one or both testes from the scrotum owing to failure of the testis or testes to descend through the inguinal canal to the testis." [HPO:curators]
Show

 HP:0000798 Oligospermia 
Show

 HP:0001450 Y-linked inheritance "A mode of inheritance that is observed for traits related to a gene encoded on the Y chromosome." [HPO:curators]
Show

 HP:0003251 Male infertility 
Show

 HP:0008734 Decreased testicular size 
Show

 HP:0011961 Non-obstructive azoospermia "Absence of any measurable level of sperm in his semen, resulting from a defect in the production of spermatozoa in the testes. Can be differentiated from obstructive azoospermia on the basis of testicular biopsy." [HPO:probinson, pmid:20514278]
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr