ENSG00000183258


Homo sapiens

Features
Gene ID: ENSG00000183258
  
Biological name :DDX41
  
Synonyms : DDX41 / DEAD-box helicase 41 / Q9UJV9
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: -1
Band: q35.3
Gene start: 177511577
Gene end: 177517469
  
Corresponding Affymetrix probe sets: 217840_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000426330
Ensembl peptide - ENSP00000487280
Ensembl peptide - ENSP00000486367
Ensembl peptide - ENSP00000427082
Ensembl peptide - ENSP00000330349
Ensembl peptide - ENSP00000421460
Ensembl peptide - ENSP00000422753
Ensembl peptide - ENSP00000425739
NCBI entrez gene - 51428     See in Manteia.
OMIM - 608170
RefSeq - NM_016222
RefSeq - NM_001321732
RefSeq - NM_001321830
RefSeq Peptide - NP_001308759
RefSeq Peptide - NP_001308661
RefSeq Peptide - NP_057306
swissprot - Q9UJV9
swissprot - D6RD33
swissprot - H0Y8L8
swissprot - H0YA06
swissprot - J3KNN5
swissprot - D6RGI7
Ensembl - ENSG00000183258
  
Related genetic diseases (OMIM): 616871 - {Myeloproliferative/lymphoproliferative neoplasms, familial (multiple types), susceptibility to}, 616871
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 DDX41ENSGALG00000042994Gallus gallus
 Ddx41ENSMUSG00000021494Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DDX3X / O00571 / DEAD-box helicase 3, X-linkedENSG0000021530132
DDX3Y / O15523 / DEAD-box helicase 3, Y-linkedENSG0000006704831
DDX4 / Q9NQI0 / DEAD-box helicase 4ENSG0000015267030
DDX59 / Q5T1V6 / DEAD-box helicase 59ENSG0000011819726
DDX1 / Q92499 / DEAD-box helicase 1ENSG0000007978519


Protein motifs (from Interpro)
Interpro ID Name
 IPR001650  Helicase, C-terminal
 IPR011545  DEAD/DEAH box helicase domain
 IPR014001  Helicase superfamily 1/2, ATP-binding domain
 IPR014014  RNA helicase, DEAD-box type, Q motif
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000398 mRNA splicing, via spliceosome IMP
 biological_processGO:0006397 mRNA processing IEA
 biological_processGO:0006915 apoptotic process TAS
 biological_processGO:0008283 cell proliferation IMP
 biological_processGO:0008380 RNA splicing IEA
 biological_processGO:0010501 RNA secondary structure unwinding IBA
 biological_processGO:0030154 cell differentiation IMP
 biological_processGO:0032479 regulation of type I interferon production TAS
 biological_processGO:0032481 positive regulation of type I interferon production TAS
 biological_processGO:0035458 cellular response to interferon-beta IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0051607 defense response to virus IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005681 spliceosomal complex IEA
 cellular_componentGO:0005730 nucleolus IBA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0071013 catalytic step 2 spliceosome IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0004004 ATP-dependent RNA helicase activity IBA
 molecular_functionGO:0004386 helicase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
STING mediated induction of host immune responses
Regulation of innate immune responses to cytosolic DNA
IRF3-mediated induction of type I IFN


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000132109 P19474 / TRIM21 / tripartite motif containing 21  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr