ENSG00000132109


Homo sapiens

Features
Gene ID: ENSG00000132109
  
Biological name :TRIM21
  
Synonyms : P19474 / TRIM21 / tripartite motif containing 21
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: -1
Band: p15.4
Gene start: 4384897
Gene end: 4393696
  
Corresponding Affymetrix probe sets: 204804_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000254436
Ensembl peptide - ENSP00000434053
NCBI entrez gene - 6737     See in Manteia.
OMIM - 109092
RefSeq - NM_003141
RefSeq Peptide - NP_003132
swissprot - P19474
swissprot - H0YDP8
Ensembl - ENSG00000132109
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Trim21ENSMUSG00000030966Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TRIM6 / Q9C030 / tripartite motif containing 6ENSG0000012123646
TRIM6-TRIM34 / TRIM6-TRIM34 readthroughENSG0000025858844
Q8NG06 / TRIM58 / tripartite motif containing 58ENSG0000016272243
Q6AZZ1 / TRIM68 / tripartite motif containing 68ENSG0000016733343
Q8IYM9 / TRIM22 / tripartite motif containing 22ENSG0000013227442
Q96F44 / TRIM11 / tripartite motif containing 11ENSG0000015437042
O00635 / TRIM38 / tripartite motif containing 38ENSG0000011234341
Q9HCM9 / TRIM39 / tripartite motif containing 39ENSG0000020459941
Q9BYJ4 / TRIM34 / tripartite motif containing 34ENSG0000025865941
TRIM5 / Q9C035 / tripartite motif containing 5ENSG0000013225641
Q9Y577 / TRIM17 / tripartite motif containing 17ENSG0000016293136
TRIM4 / Q9C037 / tripartite motif containing 4ENSG0000014683336
A6NK02 / TRIM75P / tripartite motif containing 75, pseudogeneENSG0000025037435
Q495X7 / TRIM60 / tripartite motif containing 60ENSG0000017697935
TRIM39-RPP21 / TRIM39-RPP21 readthroughENSG0000024816732


Protein motifs (from Interpro)
Interpro ID Name
 IPR000315  B-box-type zinc finger
 IPR001841  Zinc finger, RING-type
 IPR001870  B30.2/SPRY domain
 IPR003613  U box domain
 IPR003877  SPRY domain
 IPR003879  Butyrophylin-like, SPRY domain
 IPR006574  SPRY-associated
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily
 IPR017907  Zinc finger, RING-type, conserved site
 IPR020457  Zinc finger, B-box, chordata
 IPR035831  TRIM21, PRY/SPRY domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000209 protein polyubiquitination IDA
 biological_processGO:0006513 protein monoubiquitination IDA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0010508 positive regulation of autophagy IMP
 biological_processGO:0016567 protein ubiquitination IDA
 biological_processGO:0031648 protein destabilization IMP
 biological_processGO:0032088 negative regulation of NF-kappaB transcription factor activity IDA
 biological_processGO:0032479 regulation of type I interferon production TAS
 biological_processGO:0032897 negative regulation of viral transcription IDA
 biological_processGO:0034341 response to interferon-gamma IDA
 biological_processGO:0045087 innate immune response IDA
 biological_processGO:0045787 positive regulation of cell cycle IMP
 biological_processGO:0046598 positive regulation of viral entry into host cell IEA
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IDA
 biological_processGO:0051865 protein autoubiquitination IDA
 biological_processGO:0060333 interferon-gamma-mediated signaling pathway TAS
 biological_processGO:0070206 protein trimerization IDA
 biological_processGO:0090086 negative regulation of protein deubiquitination IMP
 biological_processGO:1902187 negative regulation of viral release from host cell IDA
 cellular_componentGO:0000932 P-body IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005776 autophagosome IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0019005 SCF ubiquitin ligase complex IDA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
STING mediated induction of host immune responses
Regulation of innate immune responses to cytosolic DNA
Interferon gamma signaling
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000183258 DDX41 / Q9UJV9 / DEAD-box helicase 41  / complex / reaction






 

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