ENSG00000121236


Homo sapiens

Features
Gene ID: ENSG00000121236
  
Biological name :TRIM6
  
Synonyms : Q9C030 / TRIM6 / tripartite motif containing 6
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: 1
Band: p15.4
Gene start: 5596109
Gene end: 5612958
  
Corresponding Affymetrix probe sets: 223599_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000421079
Ensembl peptide - ENSP00000484009
Ensembl peptide - ENSP00000427704
Ensembl peptide - ENSP00000421802
Ensembl peptide - ENSP00000278302
Ensembl peptide - ENSP00000369440
Ensembl peptide - ENSP00000369450
Ensembl peptide - ENSP00000399215
Ensembl peptide - ENSP00000414108
NCBI entrez gene - 117854     See in Manteia.
OMIM - 607564
RefSeq - NM_001198645
RefSeq - NM_058166
RefSeq - NM_001003818
RefSeq - NM_001198644
RefSeq Peptide - NP_001185573
RefSeq Peptide - NP_477514
RefSeq Peptide - NP_001003818
RefSeq Peptide - NP_001185574
swissprot - Q9C030
swissprot - C9JNQ0
swissprot - E9PFM0
Ensembl - ENSG00000121236
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Trim6ENSMUSG00000072244Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TRIM6-TRIM34 / TRIM6-TRIM34 readthroughENSG0000025858859
Q8IYM9 / TRIM22 / tripartite motif containing 22ENSG0000013227455
Q9BYJ4 / TRIM34 / tripartite motif containing 34ENSG0000025865954
TRIM5 / Q9C035 / tripartite motif containing 5ENSG0000013225653
P19474 / TRIM21 / tripartite motif containing 21ENSG0000013210943
Q6AZZ1 / TRIM68 / tripartite motif containing 68ENSG0000016733335
O00635 / TRIM38 / tripartite motif containing 38ENSG0000011234334
Q8NG06 / TRIM58 / tripartite motif containing 58ENSG0000016272234
Q9HCM9 / TRIM39 / tripartite motif containing 39ENSG0000020459932
Q96F44 / TRIM11 / tripartite motif containing 11ENSG0000015437032
TRIM4 / Q9C037 / tripartite motif containing 4ENSG0000014683330
Q9Y577 / TRIM17 / tripartite motif containing 17ENSG0000016293128
Q495X7 / TRIM60 / tripartite motif containing 60ENSG0000017697928
A6NK02 / TRIM75P / tripartite motif containing 75, pseudogeneENSG0000025037427
TRIM39-RPP21 / TRIM39-RPP21 readthroughENSG0000024816725


Protein motifs (from Interpro)
Interpro ID Name
 IPR000315  B-box-type zinc finger
 IPR001841  Zinc finger, RING-type
 IPR001870  B30.2/SPRY domain
 IPR003877  SPRY domain
 IPR003879  Butyrophylin-like, SPRY domain
 IPR006574  SPRY-associated
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily
 IPR017907  Zinc finger, RING-type, conserved site
 IPR027370  RING-type zinc-finger, LisH dimerisation motif
 IPR035828  TRIM6, PRY/SPRY domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000209 protein polyubiquitination IEA
 biological_processGO:0002230 positive regulation of defense response to virus by host IMP
 biological_processGO:0002741 positive regulation of cytokine secretion involved in immune response IMP
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010629 negative regulation of gene expression IMP
 biological_processGO:0010800 positive regulation of peptidyl-threonine phosphorylation IMP
 biological_processGO:0010994 free ubiquitin chain polymerization IMP
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0032496 response to lipopolysaccharide IMP
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IMP
 biological_processGO:0035458 cellular response to interferon-beta IMP
 biological_processGO:0045071 negative regulation of viral genome replication IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0060340 positive regulation of type I interferon-mediated signaling pathway IMP
 biological_processGO:0070206 protein trimerization IDA
 biological_processGO:0098586 cellular response to virus IEA
 biological_processGO:2000679 positive regulation of transcription regulatory region DNA binding IMP
 biological_processGO:2000737 negative regulation of stem cell differentiation IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0030674 protein binding, bridging IPI
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IMP
 molecular_functionGO:1990782 protein tyrosine kinase binding IPI


Pathways (from Reactome)
Pathway description
Interferon gamma signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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