ENSG00000132256


Homo sapiens

Features
Gene ID: ENSG00000132256
  
Biological name :TRIM5
  
Synonyms : Q9C035 / TRIM5 / tripartite motif containing 5
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: -1
Band: p15.4
Gene start: 5663557
Gene end: 5938619
  
Corresponding Affymetrix probe sets: 210705_s_at (Human Genome U133 Plus 2.0 Array)   223830_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000388150
Ensembl peptide - ENSP00000388031
Ensembl peptide - ENSP00000393052
Ensembl peptide - ENSP00000398196
Ensembl peptide - ENSP00000369366
Ensembl peptide - ENSP00000369373
Ensembl peptide - ENSP00000380058
NCBI entrez gene - 85363     See in Manteia.
OMIM - 608487
RefSeq - XM_017018463
RefSeq - XM_005253184
RefSeq - XM_006718358
RefSeq - XM_011520426
RefSeq - XM_011520427
RefSeq - XM_017018460
RefSeq - XM_017018461
RefSeq - XM_017018462
RefSeq - NM_033034
RefSeq - NM_033092
RefSeq - NM_033093
RefSeq - XM_005253183
RefSeq Peptide - NP_149084
RefSeq Peptide - NP_149023
RefSeq Peptide - NP_149083
swissprot - C9JWN8
swissprot - Q9C035
swissprot - H7C134
swissprot - E7EQQ5
Ensembl - ENSG00000132256
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 P15533ENSMUSG00000030921Mus musculus
 Q99PQ1ENSMUSG00000066258Mus musculus
 Trim12cENSMUSG00000057143Mus musculus
 Trim30cENSMUSG00000078616Mus musculus
 Trim30dENSMUSG00000057596Mus musculus
 Trim5ENSMUSG00000060441Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TRIM6-TRIM34 / TRIM6-TRIM34 readthroughENSG0000025858857
TRIM6 / Q9C030 / tripartite motif containing 6ENSG0000012123656
Q8IYM9 / TRIM22 / tripartite motif containing 22ENSG0000013227453
Q9BYJ4 / TRIM34 / tripartite motif containing 34ENSG0000025865953
P19474 / TRIM21 / tripartite motif containing 21ENSG0000013210940
Q6AZZ1 / TRIM68 / tripartite motif containing 68ENSG0000016733333
Q8NG06 / TRIM58 / tripartite motif containing 58ENSG0000016272233
Q96F44 / TRIM11 / tripartite motif containing 11ENSG0000015437032
O00635 / TRIM38 / tripartite motif containing 38ENSG0000011234331
Q9HCM9 / TRIM39 / tripartite motif containing 39ENSG0000020459929
TRIM4 / Q9C037 / tripartite motif containing 4ENSG0000014683328
Q9Y577 / TRIM17 / tripartite motif containing 17ENSG0000016293127
Q495X7 / TRIM60 / tripartite motif containing 60ENSG0000017697927
A6NK02 / TRIM75P / tripartite motif containing 75, pseudogeneENSG0000025037423
TRIM39-RPP21 / TRIM39-RPP21 readthroughENSG0000024816723


Protein motifs (from Interpro)
Interpro ID Name
 IPR000315  B-box-type zinc finger
 IPR001841  Zinc finger, RING-type
 IPR001870  B30.2/SPRY domain
 IPR003877  SPRY domain
 IPR003879  Butyrophylin-like, SPRY domain
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily
 IPR017907  Zinc finger, RING-type, conserved site
 IPR027370  RING-type zinc-finger, LisH dimerisation motif
 IPR032917  Tripartite motif-containing protein 5


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002218 activation of innate immune response IDA
 biological_processGO:0002221 pattern recognition receptor signaling pathway IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006914 autophagy IEA
 biological_processGO:0016032 viral process IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0031664 regulation of lipopolysaccharide-mediated signaling pathway IMP
 biological_processGO:0032880 regulation of protein localization IMP
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IMP
 biological_processGO:0043410 positive regulation of MAPK cascade IMP
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0046597 negative regulation of viral entry into host cell IDA
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IMP
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IMP
 biological_processGO:0051607 defense response to virus IEA
 biological_processGO:0060333 interferon-gamma-mediated signaling pathway TAS
 biological_processGO:0070534 protein K63-linked ubiquitination IDA
 biological_processGO:1902187 negative regulation of viral release from host cell IDA
 cellular_componentGO:0000932 P-body IDA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:1990462 omegasome IDA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0008329 signaling pattern recognition receptor activity IDA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0030674 protein binding, bridging IPI
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IPI
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Interferon gamma signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr