ENSMUSG00000030966


Mus musculus

Features
Gene ID: ENSMUSG00000030966
  
Biological name :Trim21
  
Synonyms : Trim21 / tripartite motif-containing 21
  
Possible biological names infered from orthology : P19474
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: E3
Gene start: 102557921
Gene end: 102565486
  
Corresponding Affymetrix probe sets: 10566144 (MoGene1.0st)   1418077_at (Mouse Genome 430 2.0 Array)   1448940_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000033264
Ensembl peptide - ENSMUSP00000102526
NCBI entrez gene - 20821     See in Manteia.
MGI - MGI:106657
RefSeq - NM_001082552
RefSeq - NM_009277
RefSeq Peptide - NP_001076021
RefSeq Peptide - NP_033303
swissprot - Q3U7K7
Ensembl - ENSMUSG00000030966
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 P19474ENSG00000132109Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Trim6 / Q8BGE7 / Tripartite motif-containing protein 6 / Q9C030* / tripartite motif containing 6*ENSMUSG0000007224442
Q5NCC9 / Trim58 / tripartite motif-containing 58 / Q8NG06*ENSMUSG0000003712440
Trim68 / tripartite motif-containing 68 / Q6AZZ1*ENSMUSG0000007396839
Trim39 / tripartite motif-containing 39 / Q9HCM9* / TRIM39-RPP21* / TRIM39-RPP21 readthrough*ENSMUSG0000004540938
Trim34b / TRIM34* / Q9BYJ4* / TRIM6-TRIM34* / TRIM6-TRIM34 readthrough* / tripartite motif containing 34*ENSMUSG0000009021538
Trim34a / tripartite motif-containing 34A / TRIM34* / Q9BYJ4* / TRIM6-TRIM34* / TRIM6-TRIM34 readthrough* / tripartite motif containing 34*ENSMUSG0000005614438
Q99PQ2 / Trim11 / E3 ubiquitin-protein ligase TRIM11 / Q96F44* / tripartite motif containing 11*ENSMUSG0000002045537
Trim38 / tripartite motif-containing 38 / O00635*ENSMUSG0000006414036
Trim12c / tripartite motif-containing 12C / TRIM5* / Q9C035* / tripartite motif containing 5*ENSMUSG0000005714335
Trim5 / Q9C035* / tripartite motif containing 5*ENSMUSG0000006044135
Trim30d / tripartite motif-containing 30D / TRIM5* / Q9C035* / tripartite motif containing 5*ENSMUSG0000005759634
Trim30c / TRIM5* / Q9C035* / tripartite motif containing 5*ENSMUSG0000007861634
P15533 / Trim30a / Mus musculus tripartite motif-containing 30A (Trim30a), transcript variant 2, mRNA. / TRIM5* / Q9C035* / tripartite motif containing 5*ENSMUSG0000003092134
Q7TPM3 / Trim17 / E3 ubiquitin-protein ligase TRIM17 / Q9Y577* / tripartite motif containing 17*ENSMUSG0000003696432
Q3UWZ0 / Trim75 / tripartite motif-containing 75 / A6NK02* / TRIM75P* / tripartite motif containing 75, pseudogene*ENSMUSG0000007108930
Q8VI40 / Trim60 / tripartite motif-containing 60 / Q495X7*ENSMUSG0000005349027
Trim61 / tripartite motif-containing 61ENSMUSG0000010971827
Q99PQ1 / Trim12a / Tripartite motif-containing protein 12A / TRIM5* / Q9C035* / tripartite motif containing 5*ENSMUSG0000006625821


Protein motifs (from Interpro)
Interpro ID Name
 IPR000315  B-box-type zinc finger
 IPR001841  Zinc finger, RING-type
 IPR001870  B30.2/SPRY domain
 IPR003877  SPRY domain
 IPR003879  Butyrophylin-like, SPRY domain
 IPR006574  SPRY-associated
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily
 IPR017907  Zinc finger, RING-type, conserved site
 IPR018957  Zinc finger, C3HC4 RING-type
 IPR020457  Zinc finger, B-box, chordata
 IPR035831  TRIM21, PRY/SPRY domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000209 protein polyubiquitination IEA
 biological_processGO:0006513 protein monoubiquitination IEA
 biological_processGO:0010508 positive regulation of autophagy IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0031648 protein destabilization IEA
 biological_processGO:0032088 negative regulation of NF-kappaB transcription factor activity IEA
 biological_processGO:0032897 negative regulation of viral transcription IEA
 biological_processGO:0034341 response to interferon-gamma IEA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045787 positive regulation of cell cycle IEA
 biological_processGO:0046598 positive regulation of viral entry into host cell IDA
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IEA
 biological_processGO:0051865 protein autoubiquitination IEA
 biological_processGO:0070206 protein trimerization IEA
 biological_processGO:0090086 negative regulation of protein deubiquitination IEA
 biological_processGO:1902187 negative regulation of viral release from host cell IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0019005 SCF ubiquitin ligase complex IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Regulation of innate immune responses to cytosolic DNA
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ptpn11tm1.1Wbm/Ptpn11tm1.1Wbm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL * SJL/J

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptpn11tm1.1Wbm/Ptpn11tm1.1Wbm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL * SJL/J

 MP:0001194 dermatitis "inflammation of the skin" [J:65146]
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Allelic Composition: Ptpn11tm1.1Wbm/Ptpn11tm1.1Wbm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL * SJL/J

Allelic Composition: Trim21tm1Mwah/Trim21+
Genetic Background: C57BL/6-Trim21tm1Mwah

 MP:0001828 abnormal T cell activation "anomaly in the process of producing effector T cells from naive T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Ptpn11tm1.1Wbm/Ptpn11tm1.1Wbm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL * SJL/J

 MP:0001844 autoimmune response "condition in which cells and/or antibodies arise from and are directed against one s own tissues " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ptpn11tm1.1Wbm/Ptpn11tm1.1Wbm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL * SJL/J

 MP:0001846 increased inflammatory response "greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ptpn11tm1.1Wbm/Ptpn11tm1.1Wbm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL * SJL/J

 MP:0002398 abnormal bone marrow cell morphology/development "anomalous structure or formation of the cells found in the bone marrow" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Hhextm1Jomb/Hhextm1Jomb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002962 increased protein excretion "greater than the normal amount of serum proteins voided by the kidneys" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Ptpn11tm1.1Wbm/Ptpn11tm1.1Wbm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL * SJL/J

 MP:0003725 increased autoantibody level "elevated level of antibodies to self-antigens present in the sera; often indicative of autoimmune disease" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, acv:Alicia Valenzuela, Genetic Resources Curator]
Show

Allelic Composition: Ptpn11tm1.1Wbm/Ptpn11tm1.1Wbm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL * SJL/J

 MP:0008751 abnormal interleukin level "deviation from the normal levels of soluble factors which stimulate growth-related activities of leukocytes as well as other cell types; they enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli" [MESH:D12.644.276.374.465]
Show

Allelic Composition: Ptpn11tm1.1Wbm/Ptpn11tm1.1Wbm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL * SJL/J

 MP:0008752 abnormal tumor necrosis factor level "deviation from the normal levels of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Ptpn11tm1.1Wbm/Ptpn11tm1.1Wbm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL * SJL/J

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptpn11tm1.1Wbm/Ptpn11tm1.1Wbm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL * SJL/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000021494 Ddx41 / Q91VN6 / Probable ATP-dependent RNA helicase DDX41 / Q9UJV9* / DEAD-box helicase 41*  / reaction / complex






 

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