ENSMUSG00000064140


Mus musculus

Features
Gene ID: ENSMUSG00000064140
  
Biological name :Trim38
  
Synonyms : Trim38 / tripartite motif-containing 38
  
Possible biological names infered from orthology : O00635
  
Species: Mus musculus
  
Chr. number: 13
Strand: 1
Band: A3.1
Gene start: 23769913
Gene end: 23791528
  
Corresponding Affymetrix probe sets: 10404071 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000153540
Ensembl peptide - ENSMUSP00000073709
Ensembl peptide - ENSMUSP00000153240
NCBI entrez gene - 214158     See in Manteia.
MGI - MGI:2684869
RefSeq - NM_001029935
RefSeq - XM_006516637
RefSeq - XM_011244303
RefSeq Peptide - NP_001025106
swissprot - A0A286YDR5
swissprot - Q5SZ99
Ensembl - ENSMUSG00000064140
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 O00635ENSG00000112343Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Trim21 / tripartite motif-containing 21 / P19474*ENSMUSG0000003096635
Trim39 / tripartite motif-containing 39 / Q9HCM9* / TRIM39-RPP21* / TRIM39-RPP21 readthrough*ENSMUSG0000004540933
Trim6 / Q8BGE7 / Tripartite motif-containing protein 6 / Q9C030* / tripartite motif containing 6*ENSMUSG0000007224433
Q5NCC9 / Trim58 / tripartite motif-containing 58 / Q8NG06*ENSMUSG0000003712432
Q99PQ2 / Trim11 / E3 ubiquitin-protein ligase TRIM11 / Q96F44* / tripartite motif containing 11*ENSMUSG0000002045532
Trim68 / tripartite motif-containing 68 / Q6AZZ1*ENSMUSG0000007396832
Q7TPM3 / Trim17 / E3 ubiquitin-protein ligase TRIM17 / Q9Y577* / tripartite motif containing 17*ENSMUSG0000003696430
P15533 / Trim30a / Mus musculus tripartite motif-containing 30A (Trim30a), transcript variant 2, mRNA. / TRIM5* / Q9C035* / tripartite motif containing 5*ENSMUSG0000003092128
Trim5 / Q9C035* / tripartite motif containing 5*ENSMUSG0000006044128
Trim12c / tripartite motif-containing 12C / TRIM5* / Q9C035* / tripartite motif containing 5*ENSMUSG0000005714328
Trim34a / tripartite motif-containing 34A / TRIM34* / Q9BYJ4* / TRIM6-TRIM34* / TRIM6-TRIM34 readthrough* / tripartite motif containing 34*ENSMUSG0000005614427
Trim34b / TRIM34* / Q9BYJ4* / TRIM6-TRIM34* / TRIM6-TRIM34 readthrough* / tripartite motif containing 34*ENSMUSG0000009021527
Trim30d / tripartite motif-containing 30D / TRIM5* / Q9C035* / tripartite motif containing 5*ENSMUSG0000005759627
Trim30c / TRIM5* / Q9C035* / tripartite motif containing 5*ENSMUSG0000007861627
Q3UWZ0 / Trim75 / tripartite motif-containing 75 / A6NK02* / TRIM75P* / tripartite motif containing 75, pseudogene*ENSMUSG0000007108925
Trim61 / tripartite motif-containing 61ENSMUSG0000010971824
Q8VI40 / Trim60 / tripartite motif-containing 60 / Q495X7*ENSMUSG0000005349024
Q99PQ1 / Trim12a / Tripartite motif-containing protein 12A / TRIM5* / Q9C035* / tripartite motif containing 5*ENSMUSG0000006625817


Protein motifs (from Interpro)
Interpro ID Name
 IPR000315  B-box-type zinc finger
 IPR001841  Zinc finger, RING-type
 IPR001870  B30.2/SPRY domain
 IPR003877  SPRY domain
 IPR003879  Butyrophylin-like, SPRY domain
 IPR006574  SPRY-associated
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily
 IPR017907  Zinc finger, RING-type, conserved site
 IPR035790  E3 ubiquitin-protein ligase TRIM38, PRY/SPRY domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0032648 regulation of interferon-beta production IMP
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling ISO
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IMP
 biological_processGO:0045070 positive regulation of viral genome replication IMP
 biological_processGO:0046598 positive regulation of viral entry into host cell ISO
 biological_processGO:0050687 negative regulation of defense response to virus IMP
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity ISO
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity ISO
 biological_processGO:0070936 protein K48-linked ubiquitination IMP
 cellular_componentGO:0005575 cellular_component ND
 cellular_componentGO:0005622 intracellular IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Srcinl/Srcinl
Genetic Background: involves: 129

 MP:0008553 increased circulating tumor necrosis factor level "greater amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Srcinl/Srcinl
Genetic Background: involves: 129

 MP:0008573 increased circulating interferon-alpha level "increase in the amount in the blood of one of the type I interferons produced by peripheral blood leukocytes or lymphoblastoid cells that has antiviral activity and activates natural killer cells and B cells" [MESH:D12.644.276.374.440.890.250]
Show

Allelic Composition: Srcinl/Srcinl
Genetic Background: involves: 129

 MP:0008575 increased circulating interferon-beta level "increase in the amount in the blood of one of the type I interferons produced by fibroblasts in response to stimulation by live or inactivated virus or by double-stranded RNA with antiviral, antiproliferative, and immunomodulating activity" [MESH:D12.644.276.374.440.890.275]
Show

Allelic Composition: Srcinl/Srcinl
Genetic Background: involves: 129

 MP:0008596 increased circulating interleukin-6 level "increase in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
Show

Allelic Composition: Srcinl/Srcinl
Genetic Background: involves: 129

 MP:0009787 increased susceptibility to infection induced morbidity/mortality "increased likelihood that an organism will display the expected moribund state caused by a pathogenic invasion or from components of or toxins produced by pathogens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Srcinl/Srcinl
Genetic Background: involves: 129

 MP:0009788 increased susceptibility to bacterial infection induced morbidity/mortality "increased likelihood that an organism will display the expected moribund state caused by a bacterial invasion or from components of or toxins produced by bacteria" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Srcinl/Srcinl
Genetic Background: involves: 129

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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