ENSMUSG00000021494


Mus musculus

Features
Gene ID: ENSMUSG00000021494
  
Biological name :Ddx41
  
Synonyms : Ddx41 / Probable ATP-dependent RNA helicase DDX41 / Q91VN6
  
Possible biological names infered from orthology : DEAD-box helicase 41 / Q9UJV9
  
Species: Mus musculus
  
Chr. number: 13
Strand: -1
Band: B1
Gene start: 55530410
Gene end: 55536658
  
Corresponding Affymetrix probe sets: 10409508 (MoGene1.0st)   1423814_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000021956
Ensembl peptide - ENSMUSP00000153348
NCBI entrez gene - 72935     See in Manteia.
MGI - MGI:1920185
RefSeq - XM_017315612
RefSeq - NM_134059
RefSeq - XM_017315611
RefSeq Peptide - NP_598820
swissprot - Q91VN6
swissprot - A0A1S6GWJ4
Ensembl - ENSMUSG00000021494
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 DDX41ENSGALG00000042994Gallus gallus
 DDX41ENSG00000183258Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ddx3x / Q62167 / ATP-dependent RNA helicase DDX3X / O00571* / DEAD-box helicase 3, X-linked*ENSMUSG0000000078732
D1Pas1 / P16381 / Putative ATP-dependent RNA helicase Pl10 ENSMUSG0000003922432
Ddx3y / Q62095 / ATP-dependent RNA helicase DDX3Y / O15523* / DEAD-box helicase 3, Y-linked*ENSMUSG0000006904531
Ddx4 / Q61496 / ATP-dependent RNA helicase DDX4 / Q9NQI0* / DEAD-box helicase 4*ENSMUSG0000002175830
Ddx59 / Q9DBN9 / Probable ATP-dependent RNA helicase DDX59 / Q5T1V6* / DEAD-box helicase 59*ENSMUSG0000002640426
Ddx1 / Q91VR5 / ATP-dependent RNA helicase DDX1 / Q92499* / DEAD-box helicase 1*ENSMUSG0000003714919


Protein motifs (from Interpro)
Interpro ID Name
 IPR001650  Helicase, C-terminal
 IPR011545  DEAD/DEAH box helicase domain
 IPR014001  Helicase superfamily 1/2, ATP-binding domain
 IPR014014  RNA helicase, DEAD-box type, Q motif
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000398 mRNA splicing, via spliceosome IEA
 biological_processGO:0006397 mRNA processing IEA
 biological_processGO:0008283 cell proliferation IEA
 biological_processGO:0008380 RNA splicing IEA
 biological_processGO:0010501 RNA secondary structure unwinding IBA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0035458 cellular response to interferon-beta IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0051607 defense response to virus IMP
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005681 spliceosomal complex ISO
 cellular_componentGO:0005730 nucleolus IBA
 cellular_componentGO:0005783 endoplasmic reticulum IDA
 cellular_componentGO:0071013 catalytic step 2 spliceosome IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0004004 ATP-dependent RNA helicase activity IBA
 molecular_functionGO:0004386 helicase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
STING mediated induction of host immune responses
Regulation of innate immune responses to cytosolic DNA


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Dbn1tm1b(KOMP)Wtsi/Dbn1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Dbn1tm1b(KOMP)Wtsi/Ucd

 MP:0013292 embryonic lethality prior to organogenesis "death prior to the completion of embryo turning (Mus: E9-9.5)" [MGI:smb]
Show

Allelic Composition: Dbn1tm1b(KOMP)Wtsi/Dbn1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Dbn1tm1b(KOMP)Wtsi/Ucd

 MP:0013293 embryonic lethality prior to tooth bud stage "death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb]
Show

Allelic Composition: Dbn1tm1b(KOMP)Wtsi/Dbn1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Dbn1tm1b(KOMP)Wtsi/Ucd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000030966 Trim21 / tripartite motif-containing 21 / P19474*  / reaction / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr