ENSMUSG00000037149


Mus musculus

Features
Gene ID: ENSMUSG00000037149
  
Biological name :Ddx1
  
Synonyms : ATP-dependent RNA helicase DDX1 / Ddx1 / Q91VR5
  
Possible biological names infered from orthology : DEAD-box helicase 1 / Q92499
  
Species: Mus musculus
  
Chr. number: 12
Strand: -1
Band: A1.1
Gene start: 13216973
Gene end: 13249213
  
Corresponding Affymetrix probe sets: 10399430 (MoGene1.0st)   1415915_at (Mouse Genome 430 2.0 Array)   1440816_x_at (Mouse Genome 430 2.0 Array)   1443098_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000152513
Ensembl peptide - ENSMUSP00000065987
NCBI entrez gene - 104721     See in Manteia.
MGI - MGI:2144727
RefSeq - NM_134040
RefSeq Peptide - NP_598801
swissprot - A0A1Y7VM48
swissprot - Q91VR5
Ensembl - ENSMUSG00000037149
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ddx1ENSDARG00000032117Danio rerio
 DDX1ENSGALG00000016461Gallus gallus
 DDX1ENSG00000079785Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ddx3x / Q62167 / ATP-dependent RNA helicase DDX3X / O00571* / DEAD-box helicase 3, X-linked*ENSMUSG0000000078719
Ddx3y / Q62095 / ATP-dependent RNA helicase DDX3Y / O15523* / DEAD-box helicase 3, Y-linked*ENSMUSG0000006904519
D1Pas1 / P16381 / Putative ATP-dependent RNA helicase Pl10 ENSMUSG0000003922419
Ddx4 / Q61496 / ATP-dependent RNA helicase DDX4 / Q9NQI0* / DEAD-box helicase 4*ENSMUSG0000002175818
Ddx41 / Q91VN6 / Probable ATP-dependent RNA helicase DDX41 / Q9UJV9* / DEAD-box helicase 41*ENSMUSG0000002149416
Ddx59 / Q9DBN9 / Probable ATP-dependent RNA helicase DDX59 / Q5T1V6* / DEAD-box helicase 59*ENSMUSG0000002640414


Protein motifs (from Interpro)
Interpro ID Name
 IPR001650  Helicase, C-terminal
 IPR001870  B30.2/SPRY domain
 IPR003877  SPRY domain
 IPR011545  DEAD/DEAH box helicase domain
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily
 IPR014001  Helicase superfamily 1/2, ATP-binding domain
 IPR014014  RNA helicase, DEAD-box type, Q motif
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006302 double-strand break repair IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation IEA
 biological_processGO:0006397 mRNA processing IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0008033 tRNA processing IEA
 biological_processGO:0009615 response to virus IMP
 biological_processGO:0010501 RNA secondary structure unwinding IBA
 biological_processGO:0032508 DNA duplex unwinding IEA
 biological_processGO:0043330 response to exogenous dsRNA IMP
 biological_processGO:0090305 nucleic acid phosphodiester bond hydrolysis IEA
 biological_processGO:1903608 protein localization to cytoplasmic stress granule IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005730 nucleolus IBA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0010494 cytoplasmic stress granule IEA
 cellular_componentGO:0071920 cleavage body IEA
 cellular_componentGO:0072669 tRNA-splicing ligase complex IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003712 transcription coregulator activity IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003725 double-stranded RNA binding IDA
 molecular_functionGO:0004004 ATP-dependent RNA helicase activity IBA
 molecular_functionGO:0004386 helicase activity IEA
 molecular_functionGO:0004518 nuclease activity ISO
 molecular_functionGO:0004527 exonuclease activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008026 ATP-dependent helicase activity IEA
 molecular_functionGO:0008143 poly(A) binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0033677 DNA/RNA helicase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Cecr2tm2b(EUCOMM)Hmgu/Cecr2+
Genetic Background: C57BL/6N-Cecr2tm2b(EUCOMM)Hmgu/Tcp

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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