ENSMUSG00000000787


Mus musculus

Features
Gene ID: ENSMUSG00000000787
  
Biological name :Ddx3x
  
Synonyms : ATP-dependent RNA helicase DDX3X / Ddx3x / Q62167
  
Possible biological names infered from orthology : DEAD-box helicase 3, X-linked / O00571
  
Species: Mus musculus
  
Chr. number: X
Strand: 1
Band: A1.1
Gene start: 13280970
Gene end: 13294052
  
Corresponding Affymetrix probe sets: 10546760 (MoGene1.0st)   10598723 (MoGene1.0st)   1416467_at (Mouse Genome 430 2.0 Array)   1423042_at (Mouse Genome 430 2.0 Array)   1423043_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000000804
NCBI entrez gene - 13205     See in Manteia.
MGI - MGI:103064
RefSeq - XM_006527566
RefSeq - NM_010028
RefSeq Peptide - NP_034158
swissprot - Q3TQX5
swissprot - Q62167
Ensembl - ENSMUSG00000000787
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ddx3aENSDARG00000020573Danio rerio
 ddx3bENSDARG00000005774Danio rerio
 DDX3XENSGALG00000016231Gallus gallus
 DDX3XENSG00000215301Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
D1Pas1 / P16381 / Putative ATP-dependent RNA helicase Pl10 ENSMUSG0000003922494
Ddx3y / Q62095 / ATP-dependent RNA helicase DDX3Y / O15523* / DEAD-box helicase 3, Y-linked*ENSMUSG0000006904590
Ddx4 / Q61496 / ATP-dependent RNA helicase DDX4 / Q9NQI0* / DEAD-box helicase 4*ENSMUSG0000002175842
Ddx41 / Q91VN6 / Probable ATP-dependent RNA helicase DDX41 / Q9UJV9* / DEAD-box helicase 41*ENSMUSG0000002149430
Ddx59 / Q9DBN9 / Probable ATP-dependent RNA helicase DDX59 / Q5T1V6* / DEAD-box helicase 59*ENSMUSG0000002640425
Ddx1 / Q91VR5 / ATP-dependent RNA helicase DDX1 / Q92499* / DEAD-box helicase 1*ENSMUSG0000003714921


Protein motifs (from Interpro)
Interpro ID Name
 IPR000629  ATP-dependent RNA helicase DEAD-box, conserved site
 IPR001650  Helicase, C-terminal
 IPR011545  DEAD/DEAH box helicase domain
 IPR014001  Helicase superfamily 1/2, ATP-binding domain
 IPR014014  RNA helicase, DEAD-box type, Q motif
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006413 translational initiation IBA
 biological_processGO:0006417 regulation of translation IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007059 chromosome segregation ISO
 biological_processGO:0008625 extrinsic apoptotic signaling pathway via death domain receptors ISS
 biological_processGO:0009615 response to virus ISS
 biological_processGO:0010468 regulation of gene expression IBA
 biological_processGO:0010501 RNA secondary structure unwinding ISO
 biological_processGO:0010628 positive regulation of gene expression ISO
 biological_processGO:0016055 Wnt signaling pathway ISO
 biological_processGO:0017148 negative regulation of translation ISO
 biological_processGO:0030307 positive regulation of cell growth ISS
 biological_processGO:0030308 negative regulation of cell growth ISO
 biological_processGO:0031333 negative regulation of protein complex assembly ISS
 biological_processGO:0032508 DNA duplex unwinding IEA
 biological_processGO:0034063 stress granule assembly ISO
 biological_processGO:0035556 intracellular signal transduction ISS
 biological_processGO:0042254 ribosome biogenesis IEA
 biological_processGO:0042256 mature ribosome assembly ISO
 biological_processGO:0043065 positive regulation of apoptotic process ISS
 biological_processGO:0043066 negative regulation of apoptotic process ISS
 biological_processGO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process ISS
 biological_processGO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process ISS
 biological_processGO:0045070 positive regulation of viral genome replication ISO
 biological_processGO:0045087 innate immune response ISO
 biological_processGO:0045727 positive regulation of translation ISO
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISS
 biological_processGO:0045948 positive regulation of translational initiation ISO
 biological_processGO:0071243 cellular response to arsenic-containing substance ISO
 biological_processGO:0071470 cellular response to osmotic stress ISS
 biological_processGO:0071902 positive regulation of protein serine/threonine kinase activity ISS
 biological_processGO:0090263 positive regulation of canonical Wnt signaling pathway ISS
 biological_processGO:0097193 intrinsic apoptotic signaling pathway ISS
 biological_processGO:1900087 positive regulation of G1/S transition of mitotic cell cycle ISS
 biological_processGO:1903608 protein localization to cytoplasmic stress granule ISO
 biological_processGO:2001243 negative regulation of intrinsic apoptotic signaling pathway ISS
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005730 nucleolus IBA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005741 mitochondrial outer membrane IEA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005852 eukaryotic translation initiation factor 3 complex ISS
 cellular_componentGO:0010494 cytoplasmic stress granule ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016607 nuclear speck IEA
 cellular_componentGO:0022627 cytosolic small ribosomal subunit ISS
 cellular_componentGO:0036464 cytoplasmic ribonucleoprotein granule IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding ISO
 molecular_functionGO:0003723 RNA binding ISO
 molecular_functionGO:0003924 GTPase activity ISO
 molecular_functionGO:0004003 ATP-dependent DNA helicase activity ISS
 molecular_functionGO:0004004 ATP-dependent RNA helicase activity ISO
 molecular_functionGO:0004386 helicase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008134 transcription factor binding ISS
 molecular_functionGO:0008143 poly(A) binding ISS
 molecular_functionGO:0008190 eukaryotic initiation factor 4E binding ISS
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016887 ATPase activity ISO
 molecular_functionGO:0017111 nucleoside-triphosphatase activity ISO
 molecular_functionGO:0031369 translation initiation factor binding ISS
 molecular_functionGO:0033592 RNA strand annealing activity ISO
 molecular_functionGO:0035613 RNA stem-loop binding ISO
 molecular_functionGO:0043024 ribosomal small subunit binding ISS
 molecular_functionGO:0043273 CTPase activity ISO
 molecular_functionGO:0043539 protein serine/threonine kinase activator activity ISS
 molecular_functionGO:0045296 cadherin binding ISO
 molecular_functionGO:0048027 mRNA 5"-UTR binding ISS


Pathways (from Reactome)
Pathway description
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000433 microcephaly "an abnormally small head" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ddx3xtm1.1Lyou/Y,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129 * C57BL/6 * CBA

 MP:0000913 abnormal brain development "malformed or incomplete differentiation of the brain" [MGI:cls, J:49840]
Show

Allelic Composition: Ddx3xtm1.1Lyou/Y,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129 * C57BL/6 * CBA

 MP:0001700 abnormal embryo turning "atypical axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (Mus:E8.5-E9.5) such that the curvature of the entire trunk region is reversed and the neural ectoderm moves to the convex region and the midgut region becomes located in the concave region" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ddx3xtm1.1Lyou/Y,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129 * C57BL/6 * CBA

 MP:0001713 reduced trophoblast cell number "fewer than normal number of cells of the extraembryonic cell layer that contributes to the placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:23171]
Show

Allelic Composition: Map1am1J/Map1am1J
Genetic Background: C57BLKS/J-Map1am1J/SlacJ

Allelic Composition: Ddx3xtm1.2Lyou/Ddx3x+
Genetic Background: involves: 129 * C57BL/6

 MP:0001726 abnormal allantois "malformed fetal membrane which contributes to the formation of the umbilical cord and placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:12622]
Show

Allelic Composition: Ddx3xtm1.1Lyou/Y,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129 * C57BL/6 * CBA

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
Show

Allelic Composition: Map1am1J/Map1am1J
Genetic Background: C57BLKS/J-Map1am1J/SlacJ

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ddx3xtm1.2Lyou/Ddx3x+
Genetic Background: involves: 129 * C57BL/6

 MP:0002084 abnormal developmental patterning "abnormal systematic arrangement of the developing body along an axis" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ddx3xtm1.2Lyou/Ddx3x+
Genetic Background: involves: 129 * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ddx3xtm1.1Lyou/Y,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129 * C57BL/6 * CBA

 MP:0002189 abnormal myocardial trabeculae morphology "malformation of the supporting bundles of muscular fibers lining the walls of the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ddx3xtm1.1Lyou/Y,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129 * C57BL/6 * CBA

 MP:0003077 abnormal cell cycle "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]
Show

Allelic Composition: Ddx3xtm1.1Lyou/Y,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129 * C57BL/6 * CBA

 MP:0003231 abnormal placental vasculature "malformation in the vessels of the placenta" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93157]
Show

Allelic Composition: Ddx3xtm1.2Lyou/Ddx3x+
Genetic Background: involves: 129 * C57BL/6

 MP:0003720 abnormal neural tube closure "abnormal invagination and fusion of the neuroepithelial layer in early development" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:99099]
Show

Allelic Composition: Ddx3xtm1.1Lyou/Y,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129 * C57BL/6 * CBA

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Map1am1J/Map1am1J
Genetic Background: C57BLKS/J-Map1am1J/SlacJ

Allelic Composition: Ddx3xtm1.2Lyou/Ddx3x+
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Ddx3xtm1.1Lyou/Y,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129 * C57BL/6 * CBA

 MP:0004259 small placenta "reduced size of the size or shape of the organ of metabolic interchange between fetus and mother" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ddx3xtm1.2Lyou/Ddx3x+
Genetic Background: involves: 129 * C57BL/6

 MP:0004559 small allantois "reduced size of the fetal membrane which contributes to the formation of the umbilical cord and placental blood vessels" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ddx3xtm1.1Lyou/Y,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129 * C57BL/6 * CBA

 MP:0004760 increased mitotic index "increased number of cells in G2/M phase" [Bertram_Weiss:Bayer_Schering_Pharma_AG]
Show

Allelic Composition: Ddx3xtm1.1Lyou/Y,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129 * C57BL/6 * CBA

 MP:0005033 abnormal trophoblast cells "anomaly of the cells covering the blastocyst that erode the uterine mucosa and contribute to the formation of the placenta " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator, J:57761]
Show

Allelic Composition: Ddx3xtm1.2Lyou/Ddx3x+
Genetic Background: involves: 129 * C57BL/6

 MP:0005312 pericardial effusion "escape of fluid from blood vessels or lymphatics into the fibrous sac surrounding the heart" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ddx3xtm1.1Lyou/Y,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129 * C57BL/6 * CBA

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ddx3xtm1.1Lyou/Y,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129 * C57BL/6 * CBA

 MP:0008803 abnormal placental labyrinth vasculature morphology "any structural anomaly in blood vessels of the layer of the placenta where embryonic and maternal blood vessels interdigitate" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ddx3xtm1.2Lyou/Ddx3x+
Genetic Background: involves: 129 * C57BL/6

 MP:0008959 abnormal spongiotrophoblast cell morphology "any structural anomaly of a trophoblast cell that arises in the junctional zone of the placenta" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ddx3xtm1.2Lyou/Ddx3x+
Genetic Background: involves: 129 * C57BL/6

 MP:0009657 failure of chorioallantoic fusion "failure to initiate and/or complete the formation of a highly vascularized extra-embryonic fetal membrane by fusion of the chorion and allantois" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ddx3xtm1.1Lyou/Y,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129 * C57BL/6 * CBA

 MP:0009850 embryonic lethality between implantation and placentation "death anytime after implantation but before placentation (Mus: E4.5 to less than E9)" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Map1am1J/Map1am1J
Genetic Background: C57BLKS/J-Map1am1J/SlacJ

 MP:0010402 ventricular septal defect "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]
Show

Allelic Composition: Ddx3xtm1.2Lyou/Ddx3x+
Genetic Background: involves: 129 * C57BL/6

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Ddx3xtm1.2Lyou/Ddx3x+
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Ddx3xtm1.1Lyou/Y,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129 * C57BL/6 * CBA

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Ddx3xtm1.2Lyou/Ddx3x+
Genetic Background: involves: 129 * C57BL/6

 MP:0011257 abnormal head fold morphology "any structural anomaly of the crescent-shaped, ventrally located fold of the embryonic disc at the future cephalic end of the developing embryo; it constitutes the first body fold, and initiates brain, foregut and heart development" [ISBN:0-683-40008-8, PMID:10791309]
Show

Allelic Composition: Ddx3xtm1.1Lyou/Y,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129 * C57BL/6 * CBA

 MP:0012099 decreased spongiotrophoblast size "reduction of the size of the middle layer of the placenta between the outermost giant cells and the innermost labyrinth layer; it has a structural role and also produces several layer-specific secreted factors" [MGI:csmith]
Show

Allelic Composition: Ddx3xtm1.2Lyou/Ddx3x+
Genetic Background: involves: 129 * C57BL/6

 MP:0013292 embryonic lethality prior to organogenesis "death prior to the completion of embryo turning (Mus: E9-9.5)" [MGI:smb]
Show

Allelic Composition: Map1am1J/Map1am1J
Genetic Background: C57BLKS/J-Map1am1J/SlacJ

 MP:0013293 embryonic lethality prior to tooth bud stage "death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb]
Show

Allelic Composition: Ddx3xtm1.1Lyou/Y,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129 * C57BL/6 * CBA

 MP:0013504 increased embryonic tissue cell apoptosis "increase in the timing or the number of cells in embryonic tissue undergoing programmed cell death" [MGI:csmith]
Show

Allelic Composition: Ddx3xtm1.1Lyou/Y,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129 * C57BL/6 * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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