ENSMUSG00000021758


Mus musculus

Features
Gene ID: ENSMUSG00000021758
  
Biological name :Ddx4
  
Synonyms : ATP-dependent RNA helicase DDX4 / Ddx4 / Q61496
  
Possible biological names infered from orthology : DEAD-box helicase 4 / Q9NQI0
  
Species: Mus musculus
  
Chr. number: 13
Strand: -1
Band: D2.2
Gene start: 112598333
Gene end: 112652475
  
Corresponding Affymetrix probe sets: 10412155 (MoGene1.0st)   1427242_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000075157
Ensembl peptide - ENSMUSP00000096769
NCBI entrez gene - 13206     See in Manteia.
MGI - MGI:102670
RefSeq - XM_011244622
RefSeq - NM_001145885
RefSeq - NM_010029
RefSeq - XM_006517524
RefSeq - XM_011244618
RefSeq - XM_011244619
RefSeq - XM_011244621
RefSeq Peptide - NP_034159
RefSeq Peptide - NP_001139357
swissprot - Q3V086
swissprot - Q61496
Ensembl - ENSMUSG00000021758
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ddx4ENSDARG00000014373Danio rerio
 DDX4ENSGALG00000014713Gallus gallus
 DDX4ENSG00000152670Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ddx3x / Q62167 / ATP-dependent RNA helicase DDX3X / O00571* / DEAD-box helicase 3, X-linked*ENSMUSG0000000078739
Ddx3y / Q62095 / ATP-dependent RNA helicase DDX3Y / O15523* / DEAD-box helicase 3, Y-linked*ENSMUSG0000006904537
D1Pas1 / P16381 / Putative ATP-dependent RNA helicase Pl10 ENSMUSG0000003922437
Ddx41 / Q91VN6 / Probable ATP-dependent RNA helicase DDX41 / Q9UJV9* / DEAD-box helicase 41*ENSMUSG0000002149426
Ddx59 / Q9DBN9 / Probable ATP-dependent RNA helicase DDX59 / Q5T1V6* / DEAD-box helicase 59*ENSMUSG0000002640423
Ddx1 / Q91VR5 / ATP-dependent RNA helicase DDX1 / Q92499* / DEAD-box helicase 1*ENSMUSG0000003714918


Protein motifs (from Interpro)
Interpro ID Name
 IPR000629  ATP-dependent RNA helicase DEAD-box, conserved site
 IPR001650  Helicase, C-terminal
 IPR011545  DEAD/DEAH box helicase domain
 IPR014001  Helicase superfamily 1/2, ATP-binding domain
 IPR014014  RNA helicase, DEAD-box type, Q motif
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007140 male meiotic nuclear division IMP
 biological_processGO:0007141 male meiosis I IMP
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0010501 RNA secondary structure unwinding IBA
 biological_processGO:0010529 negative regulation of transposition IMP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030317 flagellated sperm motility IEA
 biological_processGO:0031047 gene silencing by RNA IEA
 biological_processGO:0032880 regulation of protein localization IMP
 biological_processGO:0034587 piRNA metabolic process IMP
 biological_processGO:0043046 DNA methylation involved in gamete generation IMP
 biological_processGO:0051321 meiotic cell cycle IEA
 biological_processGO:1990511 piRNA biosynthetic process IMP
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005730 nucleolus IBA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0033391 chromatoid body ISO
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0071546 pi-body IDA
 cellular_componentGO:0071547 piP-body IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0004004 ATP-dependent RNA helicase activity IBA
 molecular_functionGO:0004386 helicase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016887 ATPase activity IMP


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001125 abnormal oocytes "anomalous structure of immature ova" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tyrc-Brd/Tyrc-Brd
Genetic Background: C57BL/6Brd-Tyrc-Brd

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Pnpla2tm1Eek/Pnpla2tm1Eek,Tg(Myog-cre)1Eno/0
Genetic Background: involves: 129S * C57BL/6

 MP:0001153 small seminiferous tubules "reduced diameter of the tubules in the testes where spermatogenesis occurs" [J:50844]
Show

Allelic Composition: Casp4tm1Yuan/Casp4tm1Yuan
Genetic Background: involves: 129S4/SvJae * C57BL/6J * DBA/2

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
Show

Allelic Composition: Pnpla2tm1Eek/Pnpla2tm1Eek,Tg(Myog-cre)1Eno/0
Genetic Background: involves: 129S * C57BL/6

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Casp4tm1Yuan/Casp4tm1Yuan
Genetic Background: involves: 129S4/SvJae * C57BL/6J * DBA/2

Allelic Composition: Ddx4tm1.1(cre/mOrange)Dcp/Ddx4+,Rb1tm3Tyj/Rb1tm3Tyj
Genetic Background: involves: C57BL/6

 MP:0002161 abnormal fertility/fecundity "reduced ability or inability to produce live offspring" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pnpla2tm1Eek/Pnpla2tm1Eek,Tg(Myog-cre)1Eno/0
Genetic Background: involves: 129S * C57BL/6

 MP:0002982 abnormal germ cell migration "defects in the orderly movement of a germ cell, a cell specialized to produce haploid gametes, from one site to another during development" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
Show

Allelic Composition: Casp4tm1Yuan/Casp4tm1Yuan
Genetic Background: involves: 129S4/SvJae * C57BL/6J * DBA/2

Allelic Composition: Ddx4tm1Tnc/Ddx4+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6NJcl

 MP:0003205 testicular atrophy "wasting of the male reproductive glands resulting in reduced size" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Casp4tm1Yuan/Casp4tm1Yuan
Genetic Background: involves: 129S4/SvJae * C57BL/6J * DBA/2

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ddx4tm1.1(cre/mOrange)Dcp/Ddx4+,Rb1tm3Tyj/Rb1tm3Tyj
Genetic Background: involves: C57BL/6

 MP:0006379 abnormal spermatocyte morphology "anomaly in the number or structure of male germ cells that through meiosis give rise to spermatids " [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tyrc-Brd/Tyrc-Brd
Genetic Background: C57BL/6Brd-Tyrc-Brd

 MP:0008261 arrest of male meiosis "cessation of the progression of the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Casp4tm1Yuan/Casp4tm1Yuan
Genetic Background: involves: 129S4/SvJae * C57BL/6J * DBA/2

Allelic Composition: Ddx4tm1Tnc/Ddx4tm1Tnc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008280 male germ cell apoptosis "presence of male germs cells that undergo programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Casp4tm1Yuan/Casp4tm1Yuan
Genetic Background: involves: 129S4/SvJae * C57BL/6J * DBA/2

 MP:0008390 abnormal primordial germ cell proliferation "anomaly in the ability of the primordial germ cell population to undergo rapid expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Casp4tm1Yuan/Casp4tm1Yuan
Genetic Background: involves: 129S4/SvJae * C57BL/6J * DBA/2

 MP:0008392 decreased primordial germ cell number "reduced number of a mesodermally-derived, most primitive undifferentiated sex cell, that originates in the allantois and migrates through the hindgut and into the gonadal ridge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Casp4tm1Yuan/Casp4tm1Yuan
Genetic Background: involves: 129S4/SvJae * C57BL/6J * DBA/2

Allelic Composition: Ddx4tm1Tnc/Ddx4+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6NJcl

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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