ENSG00000152670


Homo sapiens

Features
Gene ID: ENSG00000152670
  
Biological name :DDX4
  
Synonyms : DDX4 / DEAD-box helicase 4 / Q9NQI0
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: 1
Band: q11.2
Gene start: 55738017
Gene end: 55817157
  
Corresponding Affymetrix probe sets: 221630_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000424112
Ensembl peptide - ENSP00000430431
Ensembl peptide - ENSP00000427522
Ensembl peptide - ENSP00000427167
Ensembl peptide - ENSP00000425359
Ensembl peptide - ENSP00000424838
Ensembl peptide - ENSP00000424779
Ensembl peptide - ENSP00000334167
Ensembl peptide - ENSP00000347087
Ensembl peptide - ENSP00000421960
Ensembl peptide - ENSP00000423102
Ensembl peptide - ENSP00000423123
NCBI entrez gene - 54514     See in Manteia.
OMIM - 605281
RefSeq - XM_011543497
RefSeq - NM_001142549
RefSeq - NM_001166533
RefSeq - NM_001166534
RefSeq - NM_024415
RefSeq - XM_011543495
RefSeq Peptide - NP_077726
RefSeq Peptide - NP_001136021
RefSeq Peptide - NP_001160005
RefSeq Peptide - NP_001160006
swissprot - D6RAT7
swissprot - D6RAF5
swissprot - D6RCM4
swissprot - H0YBW0
swissprot - H0Y960
swissprot - Q9NQI0
swissprot - D6RIB2
swissprot - D6RBL3
Ensembl - ENSG00000152670
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ddx4ENSDARG00000014373Danio rerio
 DDX4ENSGALG00000014713Gallus gallus
 Ddx4ENSMUSG00000021758Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DDX3Y / O15523 / DEAD-box helicase 3, Y-linkedENSG0000006704840
DDX3X / O00571 / DEAD-box helicase 3, X-linkedENSG0000021530139
DDX41 / Q9UJV9 / DEAD-box helicase 41ENSG0000018325826
DDX59 / Q5T1V6 / DEAD-box helicase 59ENSG0000011819723
DDX1 / Q92499 / DEAD-box helicase 1ENSG0000007978518


Protein motifs (from Interpro)
Interpro ID Name
 IPR000629  ATP-dependent RNA helicase DEAD-box, conserved site
 IPR001650  Helicase, C-terminal
 IPR011545  DEAD/DEAH box helicase domain
 IPR014001  Helicase superfamily 1/2, ATP-binding domain
 IPR014014  RNA helicase, DEAD-box type, Q motif
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007140 male meiotic nuclear division ISS
 biological_processGO:0007141 male meiosis I ISS
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007283 spermatogenesis ISS
 biological_processGO:0010501 RNA secondary structure unwinding IBA
 biological_processGO:0010529 negative regulation of transposition ISS
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030317 flagellated sperm motility IMP
 biological_processGO:0031047 gene silencing by RNA IEA
 biological_processGO:0034587 piRNA metabolic process ISS
 biological_processGO:0043046 DNA methylation involved in gamete generation ISS
 biological_processGO:0051321 meiotic cell cycle IEA
 biological_processGO:1990511 piRNA biosynthetic process ISS
 cellular_componentGO:0005730 nucleolus IBA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0043186 P granule IBA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IBA
 cellular_componentGO:0071546 pi-body ISS
 cellular_componentGO:0071547 piP-body ISS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0004004 ATP-dependent RNA helicase activity IBA
 molecular_functionGO:0004386 helicase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016887 ATPase activity ISS


Pathways (from Reactome)
Pathway description
PIWI-interacting RNA (piRNA) biogenesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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