ENSG00000079785


Homo sapiens

Features
Gene ID: ENSG00000079785
  
Biological name :DDX1
  
Synonyms : DDX1 / DEAD-box helicase 1 / Q92499
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: 1
Band: p24.3
Gene start: 15591178
Gene end: 15631111
  
Corresponding Affymetrix probe sets: 201241_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000233084
Ensembl peptide - ENSP00000484958
Ensembl peptide - ENSP00000482416
Ensembl peptide - ENSP00000413767
Ensembl peptide - ENSP00000370745
NCBI entrez gene - 1653     See in Manteia.
OMIM - 601257
RefSeq - NM_004939
RefSeq Peptide - NP_004930
swissprot - F1T0B3
swissprot - C9JLP0
swissprot - Q92499
swissprot - A3RJH1
swissprot - A0A087X2G1
Ensembl - ENSG00000079785
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ddx1ENSDARG00000032117Danio rerio
 DDX1ENSGALG00000016461Gallus gallus
 Ddx1ENSMUSG00000037149Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DDX3X / O00571 / DEAD-box helicase 3, X-linkedENSG0000021530119
DDX4 / Q9NQI0 / DEAD-box helicase 4ENSG0000015267018
DDX3Y / O15523 / DEAD-box helicase 3, Y-linkedENSG0000006704818
DDX41 / Q9UJV9 / DEAD-box helicase 41ENSG0000018325816
DDX59 / Q5T1V6 / DEAD-box helicase 59ENSG0000011819714


Protein motifs (from Interpro)
Interpro ID Name
 IPR001650  Helicase, C-terminal
 IPR001870  B30.2/SPRY domain
 IPR003877  SPRY domain
 IPR011545  DEAD/DEAH box helicase domain
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily
 IPR014001  Helicase superfamily 1/2, ATP-binding domain
 IPR014014  RNA helicase, DEAD-box type, Q motif
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000245 spliceosomal complex assembly NAS
 biological_processGO:0006302 double-strand break repair IDA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation TAS
 biological_processGO:0006397 mRNA processing IEA
 biological_processGO:0006446 regulation of translational initiation NAS
 biological_processGO:0007275 multicellular organism development IEP
 biological_processGO:0008033 tRNA processing IEA
 biological_processGO:0009615 response to virus IEA
 biological_processGO:0010501 RNA secondary structure unwinding IBA
 biological_processGO:0032508 DNA duplex unwinding IDA
 biological_processGO:0043330 response to exogenous dsRNA IEA
 biological_processGO:0090305 nucleic acid phosphodiester bond hydrolysis IDA
 biological_processGO:1903608 protein localization to cytoplasmic stress granule IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005730 nucleolus IBA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0010494 cytoplasmic stress granule IDA
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0071920 cleavage body IDA
 cellular_componentGO:0072669 tRNA-splicing ligase complex IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0003712 transcription coregulator activity IDA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003724 RNA helicase activity TAS
 molecular_functionGO:0003725 double-stranded RNA binding IEA
 molecular_functionGO:0004004 ATP-dependent RNA helicase activity IBA
 molecular_functionGO:0004386 helicase activity IEA
 molecular_functionGO:0004518 nuclease activity IEA
 molecular_functionGO:0004527 exonuclease activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008026 ATP-dependent helicase activity IDA
 molecular_functionGO:0008143 poly(A) binding IDA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0033677 DNA/RNA helicase activity IDA


Pathways (from Reactome)
Pathway description
tRNA processing in the nucleus


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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