ENSG00000075275


Homo sapiens

Features
Gene ID: ENSG00000075275
  
Biological name :CELSR1
  
Synonyms : cadherin EGF LAG seven-pass G-type receptor 1 / CELSR1 / Q9NYQ6
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 22
Strand: -1
Band: q13.31
Gene start: 46360834
Gene end: 46537170
  
Corresponding Affymetrix probe sets: 204539_s_at (Human Genome U133 Plus 2.0 Array)   217262_s_at (Human Genome U133 Plus 2.0 Array)   41660_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000262738
Ensembl peptide - ENSP00000414689
NCBI entrez gene - 9620     See in Manteia.
OMIM - 604523
RefSeq - XM_011530555
RefSeq - NM_014246
RefSeq - XM_006724383
RefSeq - XM_011530554
RefSeq Peptide - NP_055061
swissprot - H0Y7R9
swissprot - Q9NYQ6
Ensembl - ENSG00000075275
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 celsr1aENSDARG00000069185Danio rerio
 celsr1bENSDARG00000058259Danio rerio
 CELSR1ENSGALG00000043355Gallus gallus
 Celsr1ENSMUSG00000016028Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CELSR2 / Q9HCU4 / cadherin EGF LAG seven-pass G-type receptor 2ENSG0000014312656
CELSR3 / Q9NYQ7 / cadherin EGF LAG seven-pass G-type receptor 3ENSG0000000830049
FAT1 / Q14517 / FAT atypical cadherin 1ENSG0000008385720
FAT2 / Q9NYQ8 / FAT atypical cadherin 2ENSG0000008657019
FAT4 / Q6V0I7 / FAT atypical cadherin 4ENSG0000019615918
DCHS1 / Q96JQ0 / dachsous cadherin-related 1ENSG0000016634118
FAT3 / Q8TDW7 / FAT atypical cadherin 3ENSG0000016532318
CDH23 / Q9H251 / cadherin related 23ENSG0000010773610


Protein motifs (from Interpro)
Interpro ID Name
 IPR000152  EGF-type aspartate/asparagine hydroxylation site
 IPR000203  GPS motif
 IPR000742  EGF-like domain
 IPR000832  GPCR, family 2, secretin-like
 IPR001791  Laminin G domain
 IPR001879  GPCR, family 2, extracellular hormone receptor domain
 IPR001881  EGF-like calcium-binding domain
 IPR002049  Laminin EGF domain
 IPR002126  Cadherin
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR013032  EGF-like, conserved site
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily
 IPR015919  Cadherin-like
 IPR017981  GPCR, family 2-like
 IPR020894  Cadherin conserved site
 IPR032471  GAIN domain, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001736 establishment of planar polarity IEA
 biological_processGO:0001764 neuron migration IEA
 biological_processGO:0001843 neural tube closure IEA
 biological_processGO:0001942 hair follicle development IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007166 cell surface receptor signaling pathway IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway NAS
 biological_processGO:0007266 Rho protein signal transduction IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007417 central nervous system development TAS
 biological_processGO:0007626 locomotory behavior IEA
 biological_processGO:0009952 anterior/posterior pattern specification IEA
 biological_processGO:0032956 regulation of actin cytoskeleton organization IEA
 biological_processGO:0042060 wound healing IEA
 biological_processGO:0042249 establishment of planar polarity of embryonic epithelium IEA
 biological_processGO:0042472 inner ear morphogenesis IEA
 biological_processGO:0045176 apical protein localization IEA
 biological_processGO:0048105 establishment of body hair planar orientation IEA
 biological_processGO:0060071 Wnt signaling pathway, planar cell polarity pathway NAS
 biological_processGO:0060488 orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis IEA
 biological_processGO:0060489 planar dichotomous subdivision of terminal units involved in lung branching morphogenesis IEA
 biological_processGO:0060490 lateral sprouting involved in lung morphogenesis IEA
 biological_processGO:0090179 planar cell polarity pathway involved in neural tube closure IEA
 biological_processGO:0090251 protein localization involved in establishment of planar polarity IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane TAS
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity NAS
 molecular_functionGO:0004930 G-protein coupled receptor activity NAS
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0046983 protein dimerization activity NAS


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr