ENSG00000008300


Homo sapiens

Features
Gene ID: ENSG00000008300
  
Biological name :CELSR3
  
Synonyms : cadherin EGF LAG seven-pass G-type receptor 3 / CELSR3 / Q9NYQ7
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: -1
Band: p21.31
Gene start: 48636469
Gene end: 48662915
  
Corresponding Affymetrix probe sets: 205165_at (Human Genome U133 Plus 2.0 Array)   40020_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000164024
NCBI entrez gene - 1951     See in Manteia.
OMIM - 604264
RefSeq - NM_001407
RefSeq Peptide - NP_001398
swissprot - Q9NYQ7
Ensembl - ENSG00000008300
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 celsr3ENSDARG00000055825Danio rerio
 CELSR3ENSGALG00000036763Gallus gallus
 Celsr3ENSMUSG00000023473Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CELSR2 / Q9HCU4 / cadherin EGF LAG seven-pass G-type receptor 2ENSG0000014312647
CELSR1 / Q9NYQ6 / cadherin EGF LAG seven-pass G-type receptor 1ENSG0000007527544
FAT1 / Q14517 / FAT atypical cadherin 1ENSG0000008385718
FAT3 / Q8TDW7 / FAT atypical cadherin 3ENSG0000016532317
FAT4 / Q6V0I7 / FAT atypical cadherin 4ENSG0000019615917
FAT2 / Q9NYQ8 / FAT atypical cadherin 2ENSG0000008657017
DCHS1 / Q96JQ0 / dachsous cadherin-related 1ENSG0000016634116
CDH23 / Q9H251 / cadherin related 23ENSG000001077368


Protein motifs (from Interpro)
Interpro ID Name
 IPR000203  GPS motif
 IPR000742  EGF-like domain
 IPR000832  GPCR, family 2, secretin-like
 IPR001791  Laminin G domain
 IPR001879  GPCR, family 2, extracellular hormone receptor domain
 IPR001881  EGF-like calcium-binding domain
 IPR002049  Laminin EGF domain
 IPR002126  Cadherin
 IPR013032  EGF-like, conserved site
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily
 IPR015919  Cadherin-like
 IPR017981  GPCR, family 2-like
 IPR017983  GPCR, family 2, secretin-like, conserved site
 IPR020894  Cadherin conserved site
 IPR032471  GAIN domain, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001764 neuron migration IEA
 biological_processGO:0001932 regulation of protein phosphorylation IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007166 cell surface receptor signaling pathway IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007413 axonal fasciculation IEA
 biological_processGO:0032880 regulation of protein localization IEA
 biological_processGO:0036514 dopaminergic neuron axon guidance IEA
 biological_processGO:0036515 serotonergic neuron axon guidance IEA
 biological_processGO:0060071 Wnt signaling pathway, planar cell polarity pathway NAS
 biological_processGO:0060271 cilium assembly IEA
 biological_processGO:1904938 planar cell polarity pathway involved in axon guidance IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane TAS
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity TAS
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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