ENSMUSG00000023473


Mus musculus

Features
Gene ID: ENSMUSG00000023473
  
Biological name :Celsr3
  
Synonyms : Cadherin EGF LAG seven-pass G-type receptor 3 / Celsr3 / Q91ZI0
  
Possible biological names infered from orthology : Q9NYQ7
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: F2
Gene start: 108826320
Gene end: 108852969
  
Corresponding Affymetrix probe sets: 10589130 (MoGene1.0st)   1425067_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000141429
Ensembl peptide - ENSMUSP00000150759
Ensembl peptide - ENSMUSP00000141789
Ensembl peptide - ENSMUSP00000024238
NCBI entrez gene - 107934     See in Manteia.
MGI - MGI:1858236
RefSeq - XM_017313096
RefSeq - XM_006511623
RefSeq - XM_006511625
RefSeq - XM_006511622
RefSeq - XM_006511621
RefSeq - NM_080437
RefSeq Peptide - NP_536685
swissprot - Q91ZI0
swissprot - A0A0A6YX12
swissprot - A0A0A6YW76
swissprot - A0A1L1SUG9
Ensembl - ENSMUSG00000023473
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 celsr3ENSDARG00000055825Danio rerio
 CELSR3ENSGALG00000036763Gallus gallus
 CELSR3ENSG00000008300Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Celsr2 / cadherin EGF LAG seven-pass G-type receptor 2 isoform 2 / Q9HCU4* / cadherin EGF LAG seven-pass G-type receptor 2*ENSMUSG0000006874046
Celsr1 / O35161 / Cadherin EGF LAG seven-pass G-type receptor 1 / Q9NYQ6*ENSMUSG0000001602845
Fat1 / FAT atypical cadherin 1 / Q14517*ENSMUSG0000007004718
Fat4 / Q2PZL6 / Protocadherin Fat 4 / Q6V0I7* / FAT atypical cadherin 4*ENSMUSG0000004674317
Fat2 / Q5F226 / Protocadherin Fat 2 / Q9NYQ8* / FAT atypical cadherin 2*ENSMUSG0000005533317
Fat3 / FAT atypical cadherin 3 / Q8TDW7*ENSMUSG0000007450517
Dchs1 / E9PVD3 / Protocadherin-16 / Q96JQ0* / dachsous cadherin-related 1*ENSMUSG0000003686216
Cdh23 / Q99PF4 / Cadherin-23 / Q9H251* / cadherin related 23*ENSMUSG0000001281914
Dchs2 / Mus musculus dachsous cadherin related 2 (Dchs2), mRNA.ENSMUSG0000010269214


Protein motifs (from Interpro)
Interpro ID Name
 IPR000203  GPS motif
 IPR000742  EGF-like domain
 IPR000832  GPCR, family 2, secretin-like
 IPR001791  Laminin G domain
 IPR001879  GPCR, family 2, extracellular hormone receptor domain
 IPR001881  EGF-like calcium-binding domain
 IPR002049  Laminin EGF domain
 IPR002126  Cadherin
 IPR013032  EGF-like, conserved site
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily
 IPR015919  Cadherin-like
 IPR017981  GPCR, family 2-like
 IPR017983  GPCR, family 2, secretin-like, conserved site
 IPR020894  Cadherin conserved site
 IPR032471  GAIN domain, N-terminal
 IPR036445  GPCR family 2, extracellular hormone receptor domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001764 neuron migration IMP
 biological_processGO:0001932 regulation of protein phosphorylation IMP
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007166 cell surface receptor signaling pathway IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007413 axonal fasciculation IMP
 biological_processGO:0032880 regulation of protein localization IGI
 biological_processGO:0036514 dopaminergic neuron axon guidance IMP
 biological_processGO:0036515 serotonergic neuron axon guidance IMP
 biological_processGO:0060271 cilium assembly IGI
 biological_processGO:1904938 planar cell polarity pathway involved in axon guidance IMP
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0005509 calcium ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000778 abnormal tract 
Show

Allelic Composition: Meis1tm1Mtor/Meis1tm1Mtor
Genetic Background: involves: CD-1

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
Show

Allelic Composition: Meis1tm1Mtor/Meis1tm1Mtor
Genetic Background: involves: CD-1

 MP:0000792 abnormal cortical marginal zone morphology 
Show

Allelic Composition: Meis1tm1Mtor/Meis1tm1Mtor
Genetic Background: involves: CD-1

 MP:0001177 atelectasis "collapse of the lung or any portion of the lung, or decreased or absent air in the lung, resulting in loss of lung volume " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Meis1tm1Mtor/Meis1tm1Mtor
Genetic Background: involves: CD-1

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Meis1tm1Mtor/Meis1tm1Mtor
Genetic Background: involves: CD-1

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
Show

Allelic Composition: Meis1tm1Mtor/Meis1tm1Mtor
Genetic Background: involves: CD-1

 MP:0001953 respiratory failure "cessation of or failure to commence breathing" [MGI:cls, J:60159]
Show

Allelic Composition: Meis1tm1Mtor/Meis1tm1Mtor
Genetic Background: involves: CD-1

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
Show

Allelic Composition: Meis1tm1Mtor/Meis1tm1Mtor
Genetic Background: involves: CD-1

 MP:0002184 abnormal innervation "the malformation, misprojection or malfunction of the connection of nerve fibers with a target" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Kmt2atm1Brad/Kmt2atm1Brad,Commd10Tg(Vav1-icre)A2Kio/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/10 * CBA/Ca

 MP:0002270 abnormal alveoli morphology "any structural anomaly of the outpouching of the respiratory system where gas exchange occurs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Meis1tm1Mtor/Meis1tm1Mtor
Genetic Background: involves: CD-1

 MP:0002878 abnormal corticospinal tract "anomaly in the structure or function of the fibers that arise from the cells within the cerebral cortex, pass through the medullary pyramid, and descend in the spinal cord" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Gpamtm1.1Dali/Gpamtm1.1Dali
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Celsr3tm1Agof/Celsr3tm2Agof,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

Allelic Composition: Celsr3tm1Agof/Celsr3tm2Agof,Tg(mI56i-cre,EGFP)1Kc/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0002961 abnormal axon guidance "defect in the signaling mechanisms that allow precise navigation and connections of axonal growth cones to effector tissues " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Meis1tm1Mtor/Meis1tm1Mtor
Genetic Background: involves: CD-1

 MP:0004081 abnormal globus pallidus morphology "malformation of one of the basal ganglia involved with control of voluntary movement in the brain; consists of an external and an internal segment" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Meis1tm1Mtor/Meis1tm1Mtor
Genetic Background: involves: CD-1

Allelic Composition: Celsr3tm1Mrc/Celsr3tm1Mrc
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S6/SvEvTac * C57BL/6NCr)

 MP:0004274 abnormal embryonic/fetal subventricular zone morphology "any structural anomaly in the transient proliferative population of neurons that expands exponentially during late prenatal development; it is a continuous germinal zone distinct from the ventricular zone that surrounds the brain ventricles" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:12637172]
Show

Allelic Composition: Celsr3tm1Mrc/Celsr3tm1Mrc
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S6/SvEvTac * C57BL/6NCr)

 MP:0006009 abnormal neuronal migration "defective or impaired movement of immature neurons from germinal zones to specific positions where they will reside as they mature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Kmt2atm1Brad/Kmt2atm1Brad,Commd10Tg(Vav1-icre)A2Kio/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/10 * CBA/Ca

 MP:0008128 abnormal brain internal capsule morphology "any structural anomaly of the area of white matter in the brain that lies between the lenticular and caudate nuclei, and contains a group of myelinated ascending and descending axonal fiber tracts that connects the cerebral cortex to the brain stem and spinal cord" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gpamtm1.1Dali/Gpamtm1.1Dali
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Celsr3tm1Agof/Celsr3tm2Agof,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

Allelic Composition: Celsr3tm1Agof/Celsr3tm2Agof,Tg(mI56i-cre,EGFP)1Kc/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0008129 absent brain internal capsule "absence of the area of white matter in the brain that lies between the lenticular and caudate nuclei, and contains a group of myelinated ascending and descending axonal fiber tracts that connects the cerebral cortex to the brain stem and spinal cord" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Meis1tm1Mtor/Meis1tm1Mtor
Genetic Background: involves: CD-1

 MP:0008225 abnormal anterior commissure morphology "any structural anomaly of a round bundle of nerve fibers that crosses the midline of the brain near the anterior limit of the third ventricle" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Celsr3tm1Agof/Celsr3tm2Agof,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0008227 absent anterior commissure "absence of a round bundle of nerve fibers that crosses the midline of the brain near the anterior limit of the third ventricle" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Meis1tm1Mtor/Meis1tm1Mtor
Genetic Background: involves: CD-1

Allelic Composition: Celsr3tm1Agof/Celsr3tm2Agof,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd

 MP:0009247 meteorism "swelling of the abdomen resulting from gas in the intestinal or peritoneal cavity" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Meis1tm1Mtor/Meis1tm1Mtor
Genetic Background: involves: CD-1

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Meis1tm1Mtor/Meis1tm1Mtor
Genetic Background: involves: CD-1

Allelic Composition: Celsr3tm1Mrc/Celsr3tm1Mrc
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S6/SvEvTac * C57BL/6NCr)

 MP:0011881 distended duodenum "an expansion in the volume of the portion of the small intestine that extends from the pyloris to the junction with the jejunum, as by stretching or distention" [MGI:Colin_McKerlie]
Show

Allelic Composition: Meis1tm1Mtor/Meis1tm1Mtor
Genetic Background: involves: CD-1

 MP:0012484 decreased corticospinal tract size "reduced size of the corticospinal fibers that arise from the pyramidal cells within the cerebral cortex layer V of the precentral motor area, the premotor area and the postcentral gyrus, then descend into and through the medulla to form the lateral corticospinal tract and the anterior corticospinal tract" [ISBN:0-683-40008-8]
Show

Allelic Composition: Meis1tm1Mtor/Meis1tm1Mtor
Genetic Background: involves: CD-1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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