ENSMUSG00000036862


Mus musculus

Features
Gene ID: ENSMUSG00000036862
  
Biological name :Dchs1
  
Synonyms : Dchs1 / E9PVD3 / Protocadherin-16
  
Possible biological names infered from orthology : dachsous cadherin-related 1 / Q96JQ0
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: E3
Gene start: 105752990
Gene end: 105787654
  
Corresponding Affymetrix probe sets: 10566543 (MoGene1.0st)   1429163_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000077574
Ensembl peptide - ENSMUSP00000147857
NCBI entrez gene - 233651     See in Manteia.
MGI - MGI:2685011
RefSeq - NM_001162943
RefSeq - XM_006507655
RefSeq Peptide - NP_001156415
swissprot - E9PVD3
swissprot - A0A1B0GSA3
Ensembl - ENSMUSG00000036862
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dchs1aENSDARG00000070025Danio rerio
 dchs1bENSDARG00000079850Danio rerio
 DCHS1ENSGALG00000017334Gallus gallus
 DCHS1ENSG00000166341Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dchs2 / Mus musculus dachsous cadherin related 2 (Dchs2), mRNA.ENSMUSG0000010269236
Fat4 / Q2PZL6 / Protocadherin Fat 4 / Q6V0I7* / FAT atypical cadherin 4*ENSMUSG0000004674331
Fat3 / FAT atypical cadherin 3 / Q8TDW7*ENSMUSG0000007450527
Fat2 / Q5F226 / Protocadherin Fat 2 / Q9NYQ8* / FAT atypical cadherin 2*ENSMUSG0000005533326
Fat1 / FAT atypical cadherin 1 / Q14517*ENSMUSG0000007004726
Cdh23 / Q99PF4 / Cadherin-23 / Q9H251* / cadherin related 23*ENSMUSG0000001281925
Celsr1 / O35161 / Cadherin EGF LAG seven-pass G-type receptor 1 / Q9NYQ6*ENSMUSG0000001602817
Celsr2 / cadherin EGF LAG seven-pass G-type receptor 2 isoform 2 / Q9HCU4* / cadherin EGF LAG seven-pass G-type receptor 2*ENSMUSG0000006874016
Celsr3 / Q91ZI0 / Cadherin EGF LAG seven-pass G-type receptor 3 / Q9NYQ7*ENSMUSG0000002347316


Protein motifs (from Interpro)
Interpro ID Name
 IPR002126  Cadherin
 IPR015919  Cadherin-like
 IPR020894  Cadherin conserved site
 IPR027397  Catenin binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001658 branching involved in ureteric bud morphogenesis IMP
 biological_processGO:0001736 establishment of planar polarity IC
 biological_processGO:0001822 kidney development IMP
 biological_processGO:0003007 heart morphogenesis IMP
 biological_processGO:0003183 mitral valve morphogenesis IMP
 biological_processGO:0003192 mitral valve formation IEA
 biological_processGO:0003273 cell migration involved in endocardial cushion formation IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IEA
 biological_processGO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IDA
 biological_processGO:0007389 pattern specification process IMP
 biological_processGO:0016477 cell migration IC
 biological_processGO:0021915 neural tube development IMP
 biological_processGO:0022008 neurogenesis IMP
 biological_processGO:0035329 hippo signaling IMP
 biological_processGO:0036342 post-anal tail morphogenesis IMP
 biological_processGO:0043931 ossification involved in bone maturation IMP
 biological_processGO:0048565 digestive tract development IMP
 biological_processGO:0072006 nephron development IGI
 biological_processGO:0072137 condensed mesenchymal cell proliferation IMP
 biological_processGO:0072659 protein localization to plasma membrane IMP
 biological_processGO:0090102 cochlea development IMP
 biological_processGO:0098609 cell-cell adhesion IMP
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0045177 apical part of cell IDA
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0005509 calcium ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000031 abnormal cochlea morphology "any anomaly, deformity, malformation, impairment or dysfunction of the cochlea" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator, J:21484]
Show

Allelic Composition: Sosttm1Lhe/Sosttm1Lhe
Genetic Background: involves: C57BL/6J

 MP:0000137 abnormal vertebrae morphology "malformed bony segment of the spinal column" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Sosttm1Lhe/Sosttm1Lhe
Genetic Background: involves: C57BL/6J

 MP:0000282 abnormal atrial septum morphology "abnormality in the wall between the atria of the heart, usually incomplete closure " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Sosttm1Lhe/Sosttm1Lhe
Genetic Background: involves: C57BL/6J

 MP:0000286 abnormal mitral valve morphology "malformation of the valve between the left atrium and the left ventricle of the heart" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Mc4rm3Btlr/Mc4r+
Genetic Background: C57BL/6J-Mc4rm3Btlr

Allelic Composition: Dchs1tm1.2Irv/Dchs1tm1.2Irv
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000477 abnormal intestine morphology "malformation of the digestive tube passing from the stomach to the anus" [J:48968]
Show

Allelic Composition: Sosttm1Lhe/Sosttm1Lhe
Genetic Background: involves: C57BL/6J

 MP:0000527 abnormal kidney development "anomalous differentiation of the paired organs responsible for urine secretion" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Sosttm1Lhe/Sosttm1Lhe
Genetic Background: involves: C57BL/6J

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Sosttm1Lhe/Sosttm1Lhe
Genetic Background: involves: C57BL/6J

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sosttm1Lhe/Sosttm1Lhe
Genetic Background: involves: C57BL/6J

Allelic Composition: Dchs1tm1.2Irv/Dchs1tm1.2Irv,Fat4tm1.1Hmc/Fat4tm1.1Hmc
Genetic Background: involves: 129 * C57BL/6 * CBA

 MP:0002703 abnormal renal tubules "anomalous structure or development of the loops of Henle and collecting ducts in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Sosttm1Lhe/Sosttm1Lhe
Genetic Background: involves: C57BL/6J

 MP:0002705 dilated renal tubules "enlarged lumens of the loops of Henle and/or collecting ducts of the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Sosttm1Lhe/Sosttm1Lhe
Genetic Background: involves: C57BL/6J

 MP:0002989 small kidney "reduced physical bulk one or both of the organs responsible for urine secretion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sosttm1Lhe/Sosttm1Lhe
Genetic Background: involves: C57BL/6J

 MP:0003047 abnormal thoracic vertebrae morphology "malformation of any or all of the thirteen bony segments of the spine located anterior to the lumbar vertebrae and posterior to the cervical vertebrae" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Sosttm1Lhe/Sosttm1Lhe
Genetic Background: involves: C57BL/6J

Allelic Composition: Dchs1tm1.2Irv/Dchs1tm1.2Irv,Fat4tm1.1Hmc/Fat4tm1.1Hmc
Genetic Background: involves: 129 * C57BL/6 * CBA

 MP:0003049 abnormal lumbar vertebrae morphology "malformation of any or all of the six bony segments of the spine located anterior to the sacral vertebrae and posterior to the thoracic vertebrae" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Sosttm1Lhe/Sosttm1Lhe
Genetic Background: involves: C57BL/6J

 MP:0003051 curly tail "a loop or corkscrew-like curl in the tail" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Sosttm1Lhe/Sosttm1Lhe
Genetic Background: involves: C57BL/6J

 MP:0003641 small lung "reduced size of the lung relative to normal" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95332]
Show

Allelic Composition: Sosttm1Lhe/Sosttm1Lhe
Genetic Background: involves: C57BL/6J

Allelic Composition: Dchs1tm1.2Irv/Dchs1tm1.2Irv,Fat4tm1.1Hmc/Fat4tm1.1Hmc
Genetic Background: involves: 129 * C57BL/6 * CBA

 MP:0003675 kidney cysts "abnormal membranous sacs in any portion of the pair of organs responsible for urine secretion" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Sosttm1Lhe/Sosttm1Lhe
Genetic Background: involves: C57BL/6J

 MP:0004174 abnormal spine curvature "deviation from the typical S-shape of the spine" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Sosttm1Lhe/Sosttm1Lhe
Genetic Background: involves: C57BL/6J

 MP:0004321 short sternum "reduced length of the long flat bone of the chest which articulates with clavicle and first seven rib pairs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sosttm1Lhe/Sosttm1Lhe
Genetic Background: involves: C57BL/6J

Allelic Composition: Dchs1tm1.2Irv/Dchs1tm1.2Irv,Fat4tm1.1Hmc/Fat4tm1.1Hmc
Genetic Background: involves: 129 * C57BL/6 * CBA

 MP:0004491 abnormal orientation of outer hair cell stereociliary bundles "misorientation or rotation of outer hair cell (OHC) stereociliary bundles, resulting in defective planar cell polarity of the inner ear sensory epithelium " [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dchs1tm1.2Irv/Dchs1tm1.2Irv,Fat4tm1.1Hmc/Fat4tm1.1Hmc
Genetic Background: involves: 129 * C57BL/6 * CBA

 MP:0004522 abnormal orientation of cochlear hair cell stereociliary bundles "misorientation or rotation of inner and/or outer hair cell stereociliary bundles, resulting in defective planar cell polarity of the inner ear sensory epithelium" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sosttm1Lhe/Sosttm1Lhe
Genetic Background: involves: C57BL/6J

Allelic Composition: Dchs1tm1.2Irv/Dchs1tm1.2Irv,Fat4tm1.1Hmc/Fat4tm1.1Hmc
Genetic Background: involves: 129 * C57BL/6 * CBA

 MP:0004754 abnormal kidney collecting duct "any structural anomaly of the duct that drains fluid from the nephron and either allows bodily reabsorbtion of water or allows the fluid to drain to the bladder via the ureter; the collecting duct system also maintains acid-base homeostasis" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sosttm1Lhe/Sosttm1Lhe
Genetic Background: involves: C57BL/6J

 MP:0004860 dilated kidney collecting duct "stretched or widened aperture of the luminal space of the collecting ducts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sosttm1Lhe/Sosttm1Lhe
Genetic Background: involves: C57BL/6J

 MP:0004936 abnormal ureteric bud branching morphogenesis "partial or complete failure of the ureteric bud to repeatedly divide into lobules during development of the kidney" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sosttm1Lhe/Sosttm1Lhe
Genetic Background: involves: C57BL/6J

 MP:0005225 abnormal vertebrae development "anomalous formation of the vertebrae from the sclerotome" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Sosttm1Lhe/Sosttm1Lhe
Genetic Background: involves: C57BL/6J

Allelic Composition: Dchs1tm1.2Irv/Dchs1tm1.2Irv,Fat4tm1.1Hmc/Fat4tm1.1Hmc
Genetic Background: involves: 129 * C57BL/6 * CBA

 MP:0006120 mitral valve prolapse "collapse of one or more of the mitral valve cusps backward allowing blood to leak backwards, ususally the result of enlargement of one or more of the valve cusps" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Mc4rm3Btlr/Mc4r+
Genetic Background: C57BL/6J-Mc4rm3Btlr

 MP:0008272 abnormal endochondral bone ossification "anomaly in the process of the formation of bone by the replacement of cartilage tissue with mineralized bone" [GO:0001958]
Show

Allelic Composition: Sosttm1Lhe/Sosttm1Lhe
Genetic Background: involves: C57BL/6J

Allelic Composition: Dchs1tm1.2Irv/Dchs1tm1.2Irv,Fat4tm1.1Hmc/Fat4tm1.1Hmc
Genetic Background: involves: 129 * C57BL/6 * CBA

 MP:0008277 abnormal sternum ossification "anomaly in the process of the formation of the sternum bone by the replacement of cartilage tissue with mineralized bone" [GO:0001958, MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sosttm1Lhe/Sosttm1Lhe
Genetic Background: involves: C57BL/6J

Allelic Composition: Dchs1tm1.2Irv/Dchs1tm1.2Irv,Fat4tm1.1Hmc/Fat4tm1.1Hmc
Genetic Background: involves: 129 * C57BL/6 * CBA

 MP:0010614 abnormal mitral valve cusp morphology "any structural anomaly of the two fibrous components and associated flaps of the mitral valve" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mc4rm3Btlr/Mc4r+
Genetic Background: C57BL/6J-Mc4rm3Btlr

 MP:0010617 thick mitral valve cusps 
Show

Allelic Composition: Mc4rm3Btlr/Mc4r+
Genetic Background: C57BL/6J-Mc4rm3Btlr

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Sosttm1Lhe/Sosttm1Lhe
Genetic Background: involves: C57BL/6J

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Sosttm1Lhe/Sosttm1Lhe
Genetic Background: involves: C57BL/6J

 MP:0012279 wide sternum "an increase in the width of the long flat bone of the chest that articulates with the clavicle and first seven rib pairs" [MGI:anna]
Show

Allelic Composition: Sosttm1Lhe/Sosttm1Lhe
Genetic Background: involves: C57BL/6J

Allelic Composition: Dchs1tm1.2Irv/Dchs1tm1.2Irv,Fat4tm1.1Hmc/Fat4tm1.1Hmc
Genetic Background: involves: 129 * C57BL/6 * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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