ENSMUSG00000068740


Mus musculus

Features
Gene ID: ENSMUSG00000068740
  
Biological name :Celsr2
  
Synonyms : cadherin EGF LAG seven-pass G-type receptor 2 isoform 2 / Celsr2
  
Possible biological names infered from orthology : cadherin EGF LAG seven-pass G-type receptor 2 / Q9HCU4
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: F3
Gene start: 108390851
Gene end: 108415552
  
Corresponding Affymetrix probe sets: 10501319 (MoGene1.0st)   1422073_a_at (Mouse Genome 430 2.0 Array)   1435336_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000088046
Ensembl peptide - ENSMUSP00000122329
NCBI entrez gene - 53883     See in Manteia.
MGI - MGI:1858235
RefSeq - XM_017319649
RefSeq - NM_001004177
RefSeq - NM_017392
RefSeq - XM_006501691
RefSeq - XM_006501692
RefSeq Peptide - NP_059088
RefSeq Peptide - NP_001004177
swissprot - F7BHW1
swissprot - A2AEE7
Ensembl - ENSMUSG00000068740
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 celsr2ENSDARG00000019726Danio rerio
 ENSGALG00000042961Gallus gallus
 CELSR2ENSG00000143126Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Celsr1 / O35161 / Cadherin EGF LAG seven-pass G-type receptor 1 / Q9NYQ6*ENSMUSG0000001602858
Celsr3 / Q91ZI0 / Cadherin EGF LAG seven-pass G-type receptor 3 / Q9NYQ7*ENSMUSG0000002347352
Fat1 / FAT atypical cadherin 1 / Q14517*ENSMUSG0000007004720
Fat2 / Q5F226 / Protocadherin Fat 2 / Q9NYQ8* / FAT atypical cadherin 2*ENSMUSG0000005533319
Fat3 / FAT atypical cadherin 3 / Q8TDW7*ENSMUSG0000007450519
Fat4 / Q2PZL6 / Protocadherin Fat 4 / Q6V0I7* / FAT atypical cadherin 4*ENSMUSG0000004674319
Dchs1 / E9PVD3 / Protocadherin-16 / Q96JQ0* / dachsous cadherin-related 1*ENSMUSG0000003686218
Cdh23 / Q99PF4 / Cadherin-23 / Q9H251* / cadherin related 23*ENSMUSG0000001281917
Dchs2 / Mus musculus dachsous cadherin related 2 (Dchs2), mRNA.ENSMUSG0000010269217


Protein motifs (from Interpro)
Interpro ID Name
 IPR000152  EGF-type aspartate/asparagine hydroxylation site
 IPR000203  GPS motif
 IPR000742  EGF-like domain
 IPR000832  GPCR, family 2, secretin-like
 IPR001791  Laminin G domain
 IPR001879  GPCR, family 2, extracellular hormone receptor domain
 IPR001881  EGF-like calcium-binding domain
 IPR002049  Laminin EGF domain
 IPR002126  Cadherin
 IPR013032  EGF-like, conserved site
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily
 IPR015919  Cadherin-like
 IPR017981  GPCR, family 2-like
 IPR020894  Cadherin conserved site
 IPR032471  GAIN domain, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007166 cell surface receptor signaling pathway IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0005509 calcium ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000825 dilated lateral ventricles "increase over the normal size of the horseshoe-shaped cavities of the cerebrum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:38857]
Show

Allelic Composition: C3ar1tm1Raw/C3ar1tm1Raw
Genetic Background: B6.129X1(B6)-C3ar1tm1Raw

Allelic Composition: Celsr2tm1Dgen/Celsr2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Celsr2tm1Lex/Celsr2tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0000827 dilated third ventricle "enlarged narrow cleft inferior to the corpus callosum, within the diencephalon, between the paired thalami; its floor is formed by the hypothalamus, its anterior wall by the lamina terminalis, and its roof by ependyma; it communicates with the fourth ventricle by the cerebral aqueduct, and with the lateral ventricles by the interventricular foramina" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Celsr2tm1Lex/Celsr2tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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