ENSMUSG00000046743


Mus musculus

Features
Gene ID: ENSMUSG00000046743
  
Biological name :Fat4
  
Synonyms : Fat4 / Protocadherin Fat 4 / Q2PZL6
  
Possible biological names infered from orthology : FAT atypical cadherin 4 / Q6V0I7
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: B
Gene start: 38886940
Gene end: 39011985
  
Corresponding Affymetrix probe sets: 10491732 (MoGene1.0st)   1459749_s_at (Mouse Genome 430 2.0 Array)   1460574_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000061836
NCBI entrez gene - 329628     See in Manteia.
MGI - MGI:3045256
RefSeq - NM_183221
RefSeq - XM_006535484
RefSeq Peptide - NP_899044
swissprot - Q2PZL6
Ensembl - ENSMUSG00000046743
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FAT4ENSDARG00000105285Danio rerio
 FAT4ENSGALG00000011823Gallus gallus
 FAT4ENSG00000196159Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Fat1 / FAT atypical cadherin 1 / Q14517*ENSMUSG0000007004722
Fat3 / FAT atypical cadherin 3 / Q8TDW7*ENSMUSG0000007450521
Fat2 / Q5F226 / Protocadherin Fat 2 / Q9NYQ8* / FAT atypical cadherin 2*ENSMUSG0000005533320
Dchs2 / Mus musculus dachsous cadherin related 2 (Dchs2), mRNA.ENSMUSG0000010269220
Dchs1 / E9PVD3 / Protocadherin-16 / Q96JQ0* / dachsous cadherin-related 1*ENSMUSG0000003686220
Cdh23 / Q99PF4 / Cadherin-23 / Q9H251* / cadherin related 23*ENSMUSG0000001281918
Celsr1 / O35161 / Cadherin EGF LAG seven-pass G-type receptor 1 / Q9NYQ6*ENSMUSG0000001602811
Celsr2 / cadherin EGF LAG seven-pass G-type receptor 2 isoform 2 / Q9HCU4* / cadherin EGF LAG seven-pass G-type receptor 2*ENSMUSG0000006874011
Celsr3 / Q91ZI0 / Cadherin EGF LAG seven-pass G-type receptor 3 / Q9NYQ7*ENSMUSG0000002347311


Protein motifs (from Interpro)
Interpro ID Name
 IPR000152  EGF-type aspartate/asparagine hydroxylation site
 IPR000742  EGF-like domain
 IPR001791  Laminin G domain
 IPR001881  EGF-like calcium-binding domain
 IPR002126  Cadherin
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR013032  EGF-like, conserved site
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily
 IPR013783  Immunoglobulin-like fold
 IPR015919  Cadherin-like
 IPR018097  EGF-like calcium-binding, conserved site
 IPR020894  Cadherin conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001658 branching involved in ureteric bud morphogenesis IMP
 biological_processGO:0001736 establishment of planar polarity IC
 biological_processGO:0001822 kidney development IMP
 biological_processGO:0003007 heart morphogenesis IMP
 biological_processGO:0007009 plasma membrane organization IMP
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IEA
 biological_processGO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IDA
 biological_processGO:0007219 Notch signaling pathway IMP
 biological_processGO:0008543 fibroblast growth factor receptor signaling pathway IMP
 biological_processGO:0021987 cerebral cortex development IMP
 biological_processGO:0022008 neurogenesis IMP
 biological_processGO:0035329 hippo signaling IMP
 biological_processGO:0043931 ossification involved in bone maturation IMP
 biological_processGO:0048565 digestive tract development IMP
 biological_processGO:0060122 inner ear receptor cell stereocilium organization IMP
 biological_processGO:0072006 nephron development IMP
 biological_processGO:0072137 condensed mesenchymal cell proliferation IMP
 biological_processGO:0072307 regulation of metanephric nephron tubule epithelial cell differentiation IMP
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0045177 apical part of cell IDA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000031 abnormal cochlea morphology "any anomaly, deformity, malformation, impairment or dysfunction of the cochlea" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator, J:21484]
Show

Allelic Composition: Col14a1tm1Debi/Col14a1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Fat4tm1.1Hmc/Fat4tm1.1Hmc
Genetic Background: involves: 129P2/OlaHsd

 MP:0000137 abnormal vertebrae morphology "malformed bony segment of the spinal column" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Fat4tm1.1Hmc/Fat4tm1.1Hmc
Genetic Background: involves: 129P2/OlaHsd

 MP:0000160 kyphosis "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Col14a1tm1Debi/Col14a1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000282 abnormal atrial septum morphology "abnormality in the wall between the atria of the heart, usually incomplete closure " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Fat4tm1.1Hmc/Fat4tm1.1Hmc
Genetic Background: involves: 129P2/OlaHsd

 MP:0000477 abnormal intestine morphology "malformation of the digestive tube passing from the stomach to the anus" [J:48968]
Show

Allelic Composition: Sosttm1Lhe/Sosttm1Lhe
Genetic Background: involves: C57BL/6J

 MP:0000519 hydronephrosis "dilation of the pelvis and calices of one or both kidneys" [J:56641]
Show

Allelic Composition: Fat4tm1.1Hmc/Fat4tm1.1Hmc,Vangl2Lp/Vangl2+
Genetic Background: involves: 129P2/OlaHsd * A * FVB/N

 MP:0000527 abnormal kidney development "anomalous differentiation of the paired organs responsible for urine secretion" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Col14a1tm1Debi/Col14a1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Fat4tm1.1Hmc/Fat4tm1.1Hmc
Genetic Background: involves: 129P2/OlaHsd

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Col14a1tm1Debi/Col14a1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Fat4tm1.1Hmc/Fat4tm1.1Hmc
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Dchs1tm1.2Irv/Dchs1tm1.2Irv,Fat4tm1.1Hmc/Fat4tm1.1Hmc
Genetic Background: involves: 129 * C57BL/6 * CBA

 MP:0002703 abnormal renal tubules "anomalous structure or development of the loops of Henle and collecting ducts in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Col14a1tm1Debi/Col14a1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002989 small kidney "reduced physical bulk one or both of the organs responsible for urine secretion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Col14a1tm1Debi/Col14a1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Fat4tm1.1Hmc/Fat4tm1.1Hmc
Genetic Background: involves: 129P2/OlaHsd

 MP:0003047 abnormal thoracic vertebrae morphology "malformation of any or all of the thirteen bony segments of the spine located anterior to the lumbar vertebrae and posterior to the cervical vertebrae" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Fat4tm1.1Hmc/Fat4tm1.1Hmc
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Dchs1tm1.2Irv/Dchs1tm1.2Irv,Fat4tm1.1Hmc/Fat4tm1.1Hmc
Genetic Background: involves: 129 * C57BL/6 * CBA

 MP:0003049 abnormal lumbar vertebrae morphology "malformation of any or all of the six bony segments of the spine located anterior to the sacral vertebrae and posterior to the thoracic vertebrae" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Fat4tm1.1Hmc/Fat4tm1.1Hmc
Genetic Background: involves: 129P2/OlaHsd

 MP:0003051 curly tail "a loop or corkscrew-like curl in the tail" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Col14a1tm1Debi/Col14a1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Fat4tm2Hmc/Fat4tm2Hmc
Genetic Background: involves: 129P2/OlaHsd

 MP:0003068 enlarged kidney "larger than average size of the kidney" [J:86005, pvb:Pierre Vanden Borre, Mouse Genome Informatics Curator]
Show

Allelic Composition: Fat4tm1.1Hmc/Fat4tm1.1Hmc,Vangl2Lp/Vangl2+
Genetic Background: involves: 129P2/OlaHsd * A * FVB/N

 MP:0003641 small lung "reduced size of the lung relative to normal" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95332]
Show

Allelic Composition: Fat4tm1.1Hmc/Fat4tm1.1Hmc
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Dchs1tm1.2Irv/Dchs1tm1.2Irv,Fat4tm1.1Hmc/Fat4tm1.1Hmc
Genetic Background: involves: 129 * C57BL/6 * CBA

 MP:0003675 kidney cysts "abnormal membranous sacs in any portion of the pair of organs responsible for urine secretion" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Col14a1tm1Debi/Col14a1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Fat4tm1.1Hmc/Fat4tm1.1Hmc,Vangl2Lp/Vangl2+
Genetic Background: involves: 129P2/OlaHsd * A * FVB/N

Allelic Composition: Fat4tm1.1Hmc/Fat4tm1.1Hmc,Fjx1tm1Awp/Fjx1tm1Awp
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * FVB/N

Allelic Composition: Fat4tm2Hmc/Fat4tm2Hmc
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Fat4tm1.1Hmc/Fat4tm1.1Hmc
Genetic Background: involves: 129P2/OlaHsd

 MP:0004017 duplex kidney "a kidney that is split into two separate collecting systems; there may be a duplex ureter or a single ureter; may present unilaterally or bilaterally" [rbabiuk:Randall Babiuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Fat4tm1.1Hmc/Fat4tm1.1Hmc,Fjx1tm1Awp/Fjx1tm1Awp
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * FVB/N

 MP:0004321 short sternum "reduced length of the long flat bone of the chest which articulates with clavicle and first seven rib pairs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fat4tm1.1Hmc/Fat4tm1.1Hmc
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Dchs1tm1.2Irv/Dchs1tm1.2Irv,Fat4tm1.1Hmc/Fat4tm1.1Hmc
Genetic Background: involves: 129 * C57BL/6 * CBA

 MP:0004491 abnormal orientation of outer hair cell stereociliary bundles "misorientation or rotation of outer hair cell (OHC) stereociliary bundles, resulting in defective planar cell polarity of the inner ear sensory epithelium " [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fat4tm1.1Hmc/Fat4tm1.1Hmc
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Dchs1tm1.2Irv/Dchs1tm1.2Irv,Fat4tm1.1Hmc/Fat4tm1.1Hmc
Genetic Background: involves: 129 * C57BL/6 * CBA

 MP:0004522 abnormal orientation of cochlear hair cell stereociliary bundles "misorientation or rotation of inner and/or outer hair cell stereociliary bundles, resulting in defective planar cell polarity of the inner ear sensory epithelium" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Col14a1tm1Debi/Col14a1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Fat4tm1.1Hmc/Fat4tm1.1Hmc
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Dchs1tm1.2Irv/Dchs1tm1.2Irv,Fat4tm1.1Hmc/Fat4tm1.1Hmc
Genetic Background: involves: 129 * C57BL/6 * CBA

 MP:0004754 abnormal kidney collecting duct "any structural anomaly of the duct that drains fluid from the nephron and either allows bodily reabsorbtion of water or allows the fluid to drain to the bladder via the ureter; the collecting duct system also maintains acid-base homeostasis" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Col14a1tm1Debi/Col14a1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0004936 abnormal ureteric bud branching morphogenesis "partial or complete failure of the ureteric bud to repeatedly divide into lobules during development of the kidney" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fat4tm1.1Hmc/Fat4tm1.1Hmc
Genetic Background: involves: 129P2/OlaHsd

 MP:0005225 abnormal vertebrae development "anomalous formation of the vertebrae from the sclerotome" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Fat4tm1.1Hmc/Fat4tm1.1Hmc
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Dchs1tm1.2Irv/Dchs1tm1.2Irv,Fat4tm1.1Hmc/Fat4tm1.1Hmc
Genetic Background: involves: 129 * C57BL/6 * CBA

 MP:0008272 abnormal endochondral bone ossification "anomaly in the process of the formation of bone by the replacement of cartilage tissue with mineralized bone" [GO:0001958]
Show

Allelic Composition: Fat4tm1.1Hmc/Fat4tm1.1Hmc
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Dchs1tm1.2Irv/Dchs1tm1.2Irv,Fat4tm1.1Hmc/Fat4tm1.1Hmc
Genetic Background: involves: 129 * C57BL/6 * CBA

 MP:0008277 abnormal sternum ossification "anomaly in the process of the formation of the sternum bone by the replacement of cartilage tissue with mineralized bone" [GO:0001958, MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fat4tm1.1Hmc/Fat4tm1.1Hmc
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Dchs1tm1.2Irv/Dchs1tm1.2Irv,Fat4tm1.1Hmc/Fat4tm1.1Hmc
Genetic Background: involves: 129 * C57BL/6 * CBA

 MP:0009703 decreased birth body size "reduction in average body size at birth compared to controls" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Col14a1tm1Debi/Col14a1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Fat4tm2Hmc/Fat4tm2Hmc
Genetic Background: involves: 129P2/OlaHsd

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Col14a1tm1Debi/Col14a1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Fat4tm2Hmc/Fat4tm2Hmc
Genetic Background: involves: 129P2/OlaHsd

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Fat4tm1.1Hmc/Fat4tm1.1Hmc,Fjx1tm1Awp/Fjx1tm1Awp
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * FVB/N

 MP:0011368 increased kidney apoptosis "increase in the number of cells of the kidney undergoing programmed cell death" [MGI:anna]
Show

Allelic Composition: Fat4tm1.1Hmc/Fat4tm1.1Hmc
Genetic Background: involves: 129P2/OlaHsd

 MP:0011441 decreased kidney cell proliferation "decrease in the expansion rate of any kidney cell population by cell division" [MGI:anna]
Show

Allelic Composition: Fat4tm1.1Hmc/Fat4tm1.1Hmc
Genetic Background: involves: 129P2/OlaHsd

 MP:0011493 double ureter "two ureters open separately into the renal pelvis superiorly and drain separately into the urinary bladder or genital tract; if two ureteral buds arise from the Wolffian duct, a duplex kidney with complete ureteral duplication ensues" [http://emedicine.medscape.com/article/378075-overview, MGI:anna]
Show

Allelic Composition: Fat4tm1.1Hmc/Fat4tm1.1Hmc,Fjx1tm1Awp/Fjx1tm1Awp
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * FVB/N

 MP:0012279 wide sternum "an increase in the width of the long flat bone of the chest that articulates with the clavicle and first seven rib pairs" [MGI:anna]
Show

Allelic Composition: Fat4tm1.1Hmc/Fat4tm1.1Hmc
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Dchs1tm1.2Irv/Dchs1tm1.2Irv,Fat4tm1.1Hmc/Fat4tm1.1Hmc
Genetic Background: involves: 129 * C57BL/6 * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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