ENSMUSG00000074505


Mus musculus

Features
Gene ID: ENSMUSG00000074505
  
Biological name :Fat3
  
Synonyms : Fat3 / FAT atypical cadherin 3
  
Possible biological names infered from orthology : Q8TDW7
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: A2
Gene start: 15910189
Gene end: 16501285
  
Corresponding Affymetrix probe sets: 10591090 (MoGene1.0st)   10591092 (MoGene1.0st)   10591094 (MoGene1.0st)   10591110 (MoGene1.0st)   10591112 (MoGene1.0st)   10591114 (MoGene1.0st)   10591116 (MoGene1.0st)   10591118 (MoGene1.0st)   10591120 (MoGene1.0st)   10591123 (MoGene1.0st)   10591125 (MoGene1.0st)   10591127 (MoGene1.0st)   10591129 (MoGene1.0st)   10591135 (MoGene1.0st)   1457589_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000150638
Ensembl peptide - ENSMUSP00000080808
Ensembl peptide - ENSMUSP00000148968
NCBI entrez gene - 270120     See in Manteia.
MGI - MGI:2444314
RefSeq - XM_017313398
RefSeq - XM_011242542
RefSeq - XM_011242543
RefSeq - XM_011242544
RefSeq - NM_001080814
RefSeq - XM_006510372
RefSeq - XM_006510373
RefSeq - XM_011242541
RefSeq Peptide - NP_001074283
swissprot - E9QK16
swissprot - A0A1L1SU86
Ensembl - ENSMUSG00000074505
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FAT3 (1 of many)ENSDARG00000087709Danio rerio
 fat3aENSDARG00000033840Danio rerio
 FAT3ENSGALG00000017229Gallus gallus
 FAT3ENSG00000165323Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Fat1 / FAT atypical cadherin 1 / Q14517*ENSMUSG0000007004752
Fat2 / Q5F226 / Protocadherin Fat 2 / Q9NYQ8* / FAT atypical cadherin 2*ENSMUSG0000005533340
Fat4 / Q2PZL6 / Protocadherin Fat 4 / Q6V0I7* / FAT atypical cadherin 4*ENSMUSG0000004674323
Dchs1 / E9PVD3 / Protocadherin-16 / Q96JQ0* / dachsous cadherin-related 1*ENSMUSG0000003686219
Cdh23 / Q99PF4 / Cadherin-23 / Q9H251* / cadherin related 23*ENSMUSG0000001281919
Dchs2 / Mus musculus dachsous cadherin related 2 (Dchs2), mRNA.ENSMUSG0000010269219
Celsr1 / O35161 / Cadherin EGF LAG seven-pass G-type receptor 1 / Q9NYQ6*ENSMUSG0000001602813
Celsr3 / Q91ZI0 / Cadherin EGF LAG seven-pass G-type receptor 3 / Q9NYQ7*ENSMUSG0000002347312
Celsr2 / cadherin EGF LAG seven-pass G-type receptor 2 isoform 2 / Q9HCU4* / cadherin EGF LAG seven-pass G-type receptor 2*ENSMUSG0000006874012


Protein motifs (from Interpro)
Interpro ID Name
 IPR000152  EGF-type aspartate/asparagine hydroxylation site
 IPR000742  EGF-like domain
 IPR001791  Laminin G domain
 IPR001881  EGF-like calcium-binding domain
 IPR002126  Cadherin
 IPR013032  EGF-like, conserved site
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily
 IPR015919  Cadherin-like
 IPR018097  EGF-like calcium-binding, conserved site
 IPR020894  Cadherin conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005509 calcium ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Fat3tm1.2Good/Fat3tm1.2Good,Ptf1atm1.1(cre)Cvw/Ptf1a+,Tg(CAG-Bgeo/GFP)21Lbe/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005240 abnormal amacrine cell morphology "anomalous structure of the interneurons of the retina" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Mcm9Gt(AW0655)Wtsi/Mcm9Gt(XG743)Byg
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ

Allelic Composition: Fat3tm1.2Good/Fat3tm1.2Good,Ptf1atm1.1(cre)Cvw/Ptf1a+,Tg(CAG-Bgeo/GFP)21Lbe/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Fat3tm1.2Good/Fat3tm1.2Good
Genetic Background: involves: 129P2/OlaHsd

 MP:0006069 abnormal retinal neuronal layer morphology "malformation in any of the neuronal layers that make up the retina, including the ganglion cell, inner plexiform, inner nuclear, outer plexiform, outer nuclear layers, the inner and outer segments" [smb:Susan M Bello, Mouse Genome Informatics Curator, Gray s Anatomy:ISBN 0-914294-08-3]
Show

Allelic Composition: Fat3tm1.2Good/Fat3tm1.2Good,Ptf1atm1.1(cre)Cvw/Ptf1a+,Tg(CAG-Bgeo/GFP)21Lbe/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Fat3tm1.2Good/Fat3tm1.2Good
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Fat3tm1.1Good/Fat3tm1.2Good,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Allelic Composition: Fat3tm1.2Good/Fat3tm1.2Good,Atoh7tm3(cre)Gan/Atoh7tm3(cre)Gan
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd

Allelic Composition: Fat3tm1.2Good/Fat3+,Fjx1tm1Awp/Fjx1tm1Awp
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

 MP:0006074 abnormal retinal rod bipolar cell morphology "anomalous structure of the bipolar cells that function in low light and transmit signals only through amacrine cells" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92623]
Show

Allelic Composition: Fat3tm1.2Good/Fat3tm1.2Good
Genetic Background: involves: 129P2/OlaHsd

 MP:0008508 thick retinal ganglion layer "increased thickness of the innermost nuclear layer of the retina, which contains neurons that project axons through the optic nerve to the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fat3tm1.2Good/Fat3tm1.2Good
Genetic Background: involves: 129P2/OlaHsd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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