ENSMUSG00000016028


Mus musculus

Features
Gene ID: ENSMUSG00000016028
  
Biological name :Celsr1
  
Synonyms : Cadherin EGF LAG seven-pass G-type receptor 1 / Celsr1 / O35161
  
Possible biological names infered from orthology : Q9NYQ6
  
Species: Mus musculus
  
Chr. number: 15
Strand: -1
Band: E2
Gene start: 85898929
Gene end: 86033777
  
Corresponding Affymetrix probe sets: 10431229 (MoGene1.0st)   1418925_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000016172
Ensembl peptide - ENSMUSP00000153927
Ensembl peptide - ENSMUSP00000154168
NCBI entrez gene - 12614     See in Manteia.
MGI - MGI:1100883
RefSeq - XM_006520382
RefSeq - NM_009886
RefSeq - XM_006520380
RefSeq - XM_006520381
RefSeq - XM_006520379
RefSeq Peptide - NP_034016
swissprot - O35161
Ensembl - ENSMUSG00000016028
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 celsr1aENSDARG00000069185Danio rerio
 celsr1bENSDARG00000058259Danio rerio
 CELSR1ENSGALG00000043355Gallus gallus
 CELSR1ENSG00000075275Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Celsr2 / cadherin EGF LAG seven-pass G-type receptor 2 isoform 2 / Q9HCU4* / cadherin EGF LAG seven-pass G-type receptor 2*ENSMUSG0000006874056
Celsr3 / Q91ZI0 / Cadherin EGF LAG seven-pass G-type receptor 3 / Q9NYQ7*ENSMUSG0000002347349
Fat1 / FAT atypical cadherin 1 / Q14517*ENSMUSG0000007004720
Fat2 / Q5F226 / Protocadherin Fat 2 / Q9NYQ8* / FAT atypical cadherin 2*ENSMUSG0000005533319
Fat3 / FAT atypical cadherin 3 / Q8TDW7*ENSMUSG0000007450519
Fat4 / Q2PZL6 / Protocadherin Fat 4 / Q6V0I7* / FAT atypical cadherin 4*ENSMUSG0000004674318
Dchs1 / E9PVD3 / Protocadherin-16 / Q96JQ0* / dachsous cadherin-related 1*ENSMUSG0000003686218
Dchs2 / Mus musculus dachsous cadherin related 2 (Dchs2), mRNA.ENSMUSG0000010269217
Cdh23 / Q99PF4 / Cadherin-23 / Q9H251* / cadherin related 23*ENSMUSG0000001281917


Protein motifs (from Interpro)
Interpro ID Name
 IPR000152  EGF-type aspartate/asparagine hydroxylation site
 IPR000203  GPS motif
 IPR000742  EGF-like domain
 IPR000832  GPCR, family 2, secretin-like
 IPR001791  Laminin G domain
 IPR001879  GPCR, family 2, extracellular hormone receptor domain
 IPR001881  EGF-like calcium-binding domain
 IPR002049  Laminin EGF domain
 IPR002126  Cadherin
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR013032  EGF-like, conserved site
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily
 IPR015919  Cadherin-like
 IPR017981  GPCR, family 2-like
 IPR020894  Cadherin conserved site
 IPR032471  GAIN domain, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001702 gastrulation with mouth forming second NAS
 biological_processGO:0001736 establishment of planar polarity IMP
 biological_processGO:0001764 neuron migration IMP
 biological_processGO:0001843 neural tube closure IMP
 biological_processGO:0001942 hair follicle development IMP
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IEA
 biological_processGO:0007165 signal transduction NAS
 biological_processGO:0007166 cell surface receptor signaling pathway IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007266 Rho protein signal transduction IMP
 biological_processGO:0007267 cell-cell signaling NAS
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007417 central nervous system development NAS
 biological_processGO:0007626 locomotory behavior IMP
 biological_processGO:0009952 anterior/posterior pattern specification IMP
 biological_processGO:0032956 regulation of actin cytoskeleton organization IMP
 biological_processGO:0042060 wound healing IGI
 biological_processGO:0042249 establishment of planar polarity of embryonic epithelium IMP
 biological_processGO:0042472 inner ear morphogenesis IMP
 biological_processGO:0045176 apical protein localization IMP
 biological_processGO:0046928 regulation of neurotransmitter secretion NAS
 biological_processGO:0048105 establishment of body hair planar orientation IMP
 biological_processGO:0060488 orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis IMP
 biological_processGO:0060489 planar dichotomous subdivision of terminal units involved in lung branching morphogenesis IMP
 biological_processGO:0060490 lateral sprouting involved in lung morphogenesis IMP
 biological_processGO:0090179 planar cell polarity pathway involved in neural tube closure IGI
 biological_processGO:0090251 protein localization involved in establishment of planar polarity IDA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0046983 protein dimerization activity NAS


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000383 abnormal hair follicle orientation "misaligned hair follicles; hair follicles that do not orient in a typical pattern" [J:47620]
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Allelic Composition: Fgfr2tm2Ewj/Fgfr2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0000420 ruffled hair "fuzzy, irregular appearance of the hair" [J:50844]
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Allelic Composition: Arhgap28tm2b(KOMP)Wtsi/Arhgap28tm2b(KOMP)Wtsi
Genetic Background: involves: C57BL/6J * C57BL/6N

Allelic Composition: Celsr1ctb/Celsr1ctb
Genetic Background: CByJ.Cg-Celsr1ctb/GrsrJ

 MP:0000585 kinked tail "a sharp bend or zig-zag in the tail" [J:61295]
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Allelic Composition: Fgfr2tm2Ewj/Fgfr2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Celsr1Crsh/Celsr1+,ScribCrc/Scrib+
Genetic Background: C3H.Cg-ScribCrc Celsr1Crsh

Allelic Composition: Celsr1Crsh/Celsr1+,ScribCrc/Scrib+,Vangl2Lp/Vangl2+
Genetic Background: C3H.Cg-Vangl2Lp ScribCrc Celsr1Crsh

 MP:0000919 cranioschisis "incomplete closure of the skull, usually congenital " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Fgfr2tm2Ewj/Fgfr2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0000928 incomplete cephalic closure "arrest of the fusion of the cephalic neural folds" [J:12622]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Celsr1Scy/Celsr1Scy
Genetic Background: involves: BALB/cAnN * C3H/He * C3H/HeH

 MP:0000929 open neural tube "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]
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Allelic Composition: Celsr1Crsh/Celsr1+
Genetic Background: C3H.Cg-Celsr1Crsh

 MP:0001175 abnormal lung morphology "malformed organ of respiration" [J:35802]
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Allelic Composition: Map1stm1.1Lliu/Map1stm1.1Lliu,Tg(CAG-EGFP/Map1lc3b)53Nmz/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * C57BL/6NCrj

 MP:0001178 pulmonary hypoplasia "reduced size of the respiratory organ due to incomplete development of all or part of the organ " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0]
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Allelic Composition: Map1stm1.1Lliu/Map1stm1.1Lliu,Tg(CAG-EGFP/Map1lc3b)53Nmz/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * C57BL/6NCrj

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Arhgap28tm2b(KOMP)Wtsi/Arhgap28tm2b(KOMP)Wtsi
Genetic Background: involves: C57BL/6J * C57BL/6N

Allelic Composition: Celsr1ctb/Celsr1ctb
Genetic Background: CByJ.Cg-Celsr1ctb/GrsrJ

 MP:0001340 abnormal eyelid morphology "malformation of the skin folds covering the front of the eyeball" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Celsr1Crsh/Celsr1Crsh
Genetic Background: C3H.Cg-Celsr1Crsh

Allelic Composition: Celsr1Crsh/Celsr1+,ScribCrc/Scrib+
Genetic Background: C3H.Cg-ScribCrc Celsr1Crsh

Allelic Composition: Celsr1Scy/Celsr1+,ScribCrc/Scrib+
Genetic Background: C3H.Cg-ScribCrc Celsr1Scy

 MP:0001341 absent eyelids "missing skin folds covering the front of the eyeball when closed" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61790]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Celsr1Scy/Celsr1Scy
Genetic Background: involves: BALB/cAnN * C3H/He * C3H/HeH

 MP:0001394 circling "repeated, compulsive movement in a circle; often associated with inner ear defects" [MGI:CLS, J:61295]
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Allelic Composition: Arhgap28tm2b(KOMP)Wtsi/Arhgap28tm2b(KOMP)Wtsi
Genetic Background: involves: C57BL/6J * C57BL/6N

Allelic Composition: Celsr1ctb/Celsr1ctb
Genetic Background: CByJ.Cg-Celsr1ctb/GrsrJ

 MP:0001410 head bobbing "compulsive up and down movement of the head" [J:17123]
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Allelic Composition: Hps5ru2-r/Hps5ru2-r
Genetic Background: C57BL/10

 MP:0001411 spinning "compulsive rolling of the body" [J:17123]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Celsr1Scy/Celsr1+
Genetic Background: involves: BALB/cAnN * C3H/He * C3H/HeH

 MP:0001510 abnormal coat appearance "coat that looks different from the usual state " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Arhgap28tm2b(KOMP)Wtsi/Arhgap28tm2b(KOMP)Wtsi
Genetic Background: involves: C57BL/6J * C57BL/6N

Allelic Composition: Celsr1ctb/Celsr1ctb
Genetic Background: CByJ.Cg-Celsr1ctb/GrsrJ

 MP:0001706 abnormal left-right axis patterning "anomaly in the formation or development of the body or a specific organ of the body in relation to the left and right sides of the body or organ" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Celsr1Crsh/Celsr1Crsh
Genetic Background: C3H.Cg-Celsr1Crsh

 MP:0001850 otitis media "middle ear inflammation" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60896]
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Allelic Composition: Arhgap28tm2b(KOMP)Wtsi/Arhgap28tm2b(KOMP)Wtsi
Genetic Background: involves: C57BL/6J * C57BL/6N

Allelic Composition: Celsr1ctb/Celsr1ctb
Genetic Background: CByJ.Cg-Celsr1ctb/GrsrJ

 MP:0001891 hydroencephaly "excessive accumulation of cerebrospinal fluid in the brain, especially the cerebral ventricles, often leading to increased brain size and other brain trauma" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Arhgap28tm2b(KOMP)Wtsi/Arhgap28tm2b(KOMP)Wtsi
Genetic Background: involves: C57BL/6J * C57BL/6N

Allelic Composition: Celsr1ctb/Celsr1ctb
Genetic Background: CByJ.Cg-Celsr1ctb/GrsrJ

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
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Allelic Composition: Arhgap28tm2b(KOMP)Wtsi/Arhgap28tm2b(KOMP)Wtsi
Genetic Background: involves: C57BL/6J * C57BL/6N

Allelic Composition: Celsr1ctb/Celsr1ctb
Genetic Background: CByJ.Cg-Celsr1ctb/GrsrJ

 MP:0001967 deafness "inability to hear" [J:57651]
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Allelic Composition: Arhgap28tm2b(KOMP)Wtsi/Arhgap28tm2b(KOMP)Wtsi
Genetic Background: involves: C57BL/6J * C57BL/6N

Allelic Composition: Celsr1ctb/Celsr1ctb
Genetic Background: CByJ.Cg-Celsr1ctb/GrsrJ

 MP:0002080 prenatal lethality "death anytime between fertilization and E18.5" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Arhgap28tm2b(KOMP)Wtsi/Arhgap28tm2b(KOMP)Wtsi
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0002084 abnormal developmental patterning "abnormal systematic arrangement of the developing body along an axis" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Celsr1Crsh/Celsr1+,ScribCrc/Scrib+
Genetic Background: C3H.Cg-ScribCrc Celsr1Crsh

 MP:0002111 abnormal tail morphology "abnormal development of the tail resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Celsr1Crsh/Celsr1+,ScribCrc/Scrib+,Vangl2Lp/Vangl2+
Genetic Background: C3H.Cg-Vangl2Lp ScribCrc Celsr1Crsh

 MP:0002621 delayed neural tube closure "delayed fusion of the neuroepithelial layer in early development" [J:79790, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: MtdhGt(XB780)Byg/MtdhGt(XB780)Byg,Tg(MMTVneu)202Mul/0
Genetic Background: FVB.Cg-MtdhGt(XB780)Byg Tg(MMTVneu)202Mul

 MP:0002730 head shaking "compulsive movement of the head in the horizontal plane" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:274]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Celsr1Scy/Celsr1+
Genetic Background: involves: BALB/cAnN * C3H/He * C3H/HeH

Allelic Composition: Celsr1Crsh/Celsr1+
Genetic Background: C3H.Cg-Celsr1Crsh

 MP:0003051 curly tail "a loop or corkscrew-like curl in the tail" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: ScribCrc/ScribCrc
Genetic Background: involves: C3H/HeH * C57BL/6 * C57BL/6J * NMRI

Allelic Composition: Celsr1Crsh/Celsr1+,ScribCrc/Scrib+
Genetic Background: C3H.Cg-ScribCrc Celsr1Crsh

Allelic Composition: Celsr1ctb-2J/Celsr1ctb-2J
Genetic Background: STOCK Celsr1ctb-2J/GrsrJ

Allelic Composition: Celsr1ctb/Celsr1ctb
Genetic Background: CByJ.Cg-Celsr1ctb/GrsrJ

 MP:0003052 omphalocele "protrusion of abdominal viscera at the base of the umbilical cord, with a covering membranous sac of peritoneum-amnion" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Celsr1Crsh/Celsr1+,Vangl2Lp/Vangl2+
Genetic Background: C3H.Cg-Vangl2Lp Celsr1Crsh

 MP:0003054 spina bifida "common congenital midline defect of fusion of the vertebral arch" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Ptk7chz/Ptk7+,Vangl2Lp/Vangl2+
Genetic Background: involves: A * BALB/cAnN * C3H/HeH

Allelic Composition: Celsr1Crsh/Celsr1+,ScribCrc/Scrib+
Genetic Background: C3H.Cg-ScribCrc Celsr1Crsh

 MP:0003205 testicular atrophy "wasting of the male reproductive glands resulting in reduced size" [RGD:Rat Genome Database submission]
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Allelic Composition: Celsr1ctb-2J/Celsr1ctb-2J
Genetic Background: STOCK Celsr1ctb-2J/GrsrJ

Allelic Composition: Celsr1ctb/Celsr1ctb
Genetic Background: CByJ.Cg-Celsr1ctb/GrsrJ

 MP:0003257 abnormal abdominal wall "malformation in the margins that enclose the abdominal cavity; the major part is muscular but also includes skin, subcutaneous fat, fascia and the parietal peritoneum" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Celsr1Crsh/Celsr1+,ScribCrc/Scrib+
Genetic Background: C3H.Cg-ScribCrc Celsr1Crsh

Allelic Composition: Celsr1Scy/Celsr1+,ScribCrc/Scrib+
Genetic Background: C3H.Cg-ScribCrc Celsr1Scy

 MP:0003308 abnormal cochlear sensory epithelium 
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Celsr1Crsh/Celsr1+
Genetic Background: involves: 101/H * BALB/c * C3H/HeH

Allelic Composition: Celsr1Scy/Celsr1+
Genetic Background: involves: BALB/cAnN * C3H/He * C3H/HeH

Allelic Composition: Celsr1Scy/Celsr1Scy
Genetic Background: involves: BALB/cAnN * C3H/He * C3H/HeH

 MP:0003492 abnormal involuntary movement "anomalies in movements that occur independent of planning (eg. reflexive behavior)" [Nmice:Neuromice Consortium Submission]
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Allelic Composition: Hps5ru2-r/Hps5ru2-r
Genetic Background: C57BL/10

 MP:0003641 small lung "reduced size of the lung relative to normal" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95332]
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Allelic Composition: Map1stm1.1Lliu/Map1stm1.1Lliu,Tg(CAG-EGFP/Map1lc3b)53Nmz/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * C57BL/6NCrj

 MP:0003720 abnormal neural tube closure "abnormal invagination and fusion of the neuroepithelial layer in early development" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:99099]
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Allelic Composition: Fgfr2tm2Ewj/Fgfr2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0004300 abnormal supporting cell morphology "any structural abnormality in the highly differentiated epithelial cells with distinctive morphological features surrounding the hair cells in the organ of Corti; inner hair cells (IHCs) are normally surrounded by (inner and outer) phalangeal cells while OHCs are in contact with Deiters and pillar cells; Hensen cells are positioned further laterally in the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Celsr1Scy/Celsr1+
Genetic Background: involves: BALB/cAnN * C3H/He * C3H/HeH

 MP:0004391 abnormal respiratory conducting tube "any structural anomaly of the tubes of the respiratory system that allows passage of air from the trachea to the alveoli of the lungs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Map1stm1.1Lliu/Map1stm1.1Lliu,Tg(CAG-EGFP/Map1lc3b)53Nmz/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * C57BL/6NCrj

 MP:0004404 cochlear outer hair cell degeneration "degeneration or loss of the columnar outer hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Celsr1Scy/Celsr1+
Genetic Background: involves: BALB/cAnN * C3H/He * C3H/HeH

 MP:0004491 abnormal orientation of outer hair cell stereociliary bundles "misorientation or rotation of outer hair cell (OHC) stereociliary bundles, resulting in defective planar cell polarity of the inner ear sensory epithelium " [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Celsr1Crsh/Celsr1+
Genetic Background: involves: 101/H * BALB/c * C3H/HeH

Allelic Composition: Celsr1Scy/Celsr1+
Genetic Background: involves: BALB/cAnN * C3H/He * C3H/HeH

Allelic Composition: Celsr1Scy/Celsr1Scy
Genetic Background: involves: BALB/cAnN * C3H/He * C3H/HeH

 MP:0005307 head tossing "compulsive flailing of the head in multiple directions" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Arhgap28tm2b(KOMP)Wtsi/Arhgap28tm2b(KOMP)Wtsi
Genetic Background: involves: C57BL/6J * C57BL/6N

Allelic Composition: Celsr1ctb/Celsr1ctb
Genetic Background: CByJ.Cg-Celsr1ctb/GrsrJ

 MP:0005657 abnormal neural plate morphology "malformation or absence of the neuroectodermal area of the embryo s dorsal surface that develops into the neural tube and neural crest" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator, J:68142]
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Allelic Composition: Celsr1Crsh/Celsr1+
Genetic Background: C3H.Cg-Celsr1Crsh

 MP:0006026 dilated terminal bronchiole tubes "increased volume of the terminal lung buds" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, smb:Susan M Bello, Mouse Genome Informatics Curator, J:85546]
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Allelic Composition: Map1stm1.1Lliu/Map1stm1.1Lliu,Tg(CAG-EGFP/Map1lc3b)53Nmz/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * C57BL/6NCrj

 MP:0006325 impaired hearing "reduced ability to percieve auditory stimuli" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Celsr1ctb-2J/Celsr1ctb-2J
Genetic Background: STOCK Celsr1ctb-2J/GrsrJ

Allelic Composition: Celsr1ctb/Celsr1ctb
Genetic Background: CByJ.Cg-Celsr1ctb/GrsrJ

 MP:0006382 abnormal lung epithelium morphology "any structural anomaly of the epithelial layer of the lung" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Map1stm1.1Lliu/Map1stm1.1Lliu,Tg(CAG-EGFP/Map1lc3b)53Nmz/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * C57BL/6NCrj

 MP:0008784 craniorachischisis "congenital fissure of the skull and vertebral column" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Celsr1Scy/Celsr1Scy
Genetic Background: involves: BALB/cAnN * C3H/He * C3H/HeH

Allelic Composition: Celsr1Crsh/Celsr1Scy
Genetic Background: involves: 101/H * BALB/c * C3H/He * C3H/HeH

Allelic Composition: Celsr1Crsh/Celsr1+,Vangl2Lp/Vangl2+
Genetic Background: involves: 101/H * BALB/c * C3H/HeH * CBA * LPT/Le

Allelic Composition: Celsr1Crsh/Celsr1+,ScribCrc/Scrib+
Genetic Background: involves: 101/H * BALB/c * C3H/HeH * C57BL/6 * NMRI

Allelic Composition: Celsr1Crsh/Celsr1Crsh
Genetic Background: C3H.Cg-Celsr1Crsh

Allelic Composition: Celsr1Crsh/Celsr1+,Vangl2Lp/Vangl2+
Genetic Background: C3H.Cg-Vangl2Lp Celsr1Crsh

Allelic Composition: Celsr1Crsh/Celsr1+,ScribCrc/Scrib+
Genetic Background: C3H.Cg-ScribCrc Celsr1Crsh

Allelic Composition: Celsr1Scy/Celsr1+,ScribCrc/Scrib+
Genetic Background: C3H.Cg-ScribCrc Celsr1Scy

Allelic Composition: Celsr1Crsh/Celsr1+,ScribCrc/Scrib+,Vangl2Lp/Vangl2+
Genetic Background: C3H.Cg-Vangl2Lp ScribCrc Celsr1Crsh

 MP:0009457 whorled hair "an area of hair growing opposite in direction to the rest of the hair, a curl or swirl" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Fgfr2tm2Ewj/Fgfr2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Celsr1tm1Fati/Celsr1tm1Fati,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ

 MP:0009651 abnormal eyelid development "aberrant formation of the skin folds covering the front of the eyeball" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Celsr1Crsh/Celsr1+,ScribCrc/Scrib+
Genetic Background: C3H.Cg-ScribCrc Celsr1Crsh

 MP:0010825 abnormal lung saccule morphology "any structural anomaly of the transient dilations of the developing alveolar (or transient) ducts, which transform into a transitory alveolar duct as soon as it develops further branches; the last transitory saccule formed on each pathway is a terminal saccule that develops into an alveolar sac after birth" [GO:0060430, ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Map1stm1.1Lliu/Map1stm1.1Lliu,Tg(CAG-EGFP/Map1lc3b)53Nmz/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * C57BL/6NCrj

 MP:0010975 abnormal lung lobe morphology "any structural anomaly of any of the anatomically and functionally distinct subunits (lobes) comprising the left or right lung, where each lobe receives air from its own secondary bronchus and is separated from it neighbors by one or more fissures (walls of connective tissue)" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Map1stm1.1Lliu/Map1stm1.1Lliu,Tg(CAG-EGFP/Map1lc3b)53Nmz/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * C57BL/6NCrj

 MP:0010976 small lung lobe "reduced size of any of the anatomically and functionally distinct subunits (lobes) comprising the left or right lung, where each lobe receives air from its own secondary bronchus and is separated from it neighbors by one or more fissures (walls of connective tissue)" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Map1stm1.1Lliu/Map1stm1.1Lliu,Tg(CAG-EGFP/Map1lc3b)53Nmz/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * C57BL/6NCrj

 MP:0011024 abnormal branching involved in lung morphogenesis "anomaly in the process in which the branched structure of the respiratory airway tree is generated and organized" [MGI:csmith]
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Allelic Composition: Map1stm1.1Lliu/Map1stm1.1Lliu,Tg(CAG-EGFP/Map1lc3b)53Nmz/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * C57BL/6NCrj

 MP:0011032 impaired branching involved in terminal bronchiole morphogenesis 
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Allelic Composition: Map1stm1.1Lliu/Map1stm1.1Lliu,Tg(CAG-EGFP/Map1lc3b)53Nmz/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * C57BL/6NCrj

 MP:0011062 abnormal outer hair cell kinocilium morphology "any structural anomaly of the nonmotile primary cilium that is found at the apical surface of outer hair cells" [GO:0060091]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Celsr1Scy/Celsr1Scy
Genetic Background: involves: BALB/cAnN * C3H/He * C3H/HeH

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Celsr1Scy/Celsr1Scy
Genetic Background: involves: BALB/cAnN * C3H/He * C3H/HeH

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Fgfr2tm2Ewj/Fgfr2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Celsr1ctb-2J/Celsr1ctb-2J
Genetic Background: STOCK Celsr1ctb-2J/GrsrJ

Allelic Composition: Celsr1ctb/Celsr1ctb
Genetic Background: CByJ.Cg-Celsr1ctb/GrsrJ

 MP:0011143 thick lung-associated mesenchyme "increased thickness of the mesenchymal cell layer due to delay or failure of the mesenchymal compartment to thin down during the late stages of embryonic lung development" [MGI:anna]
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Allelic Composition: Map1stm1.1Lliu/Map1stm1.1Lliu,Tg(CAG-EGFP/Map1lc3b)53Nmz/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * C57BL/6NCrj

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
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Allelic Composition: Celsr1ctb-2J/Celsr1ctb-2J
Genetic Background: STOCK Celsr1ctb-2J/GrsrJ

Allelic Composition: Celsr1ctb/Celsr1ctb
Genetic Background: CByJ.Cg-Celsr1ctb/GrsrJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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