ENSG00000143126


Homo sapiens

Features
Gene ID: ENSG00000143126
  
Biological name :CELSR2
  
Synonyms : cadherin EGF LAG seven-pass G-type receptor 2 / CELSR2 / Q9HCU4
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: p13.3
Gene start: 109250019
Gene end: 109275750
  
Corresponding Affymetrix probe sets: 204029_at (Human Genome U133 Plus 2.0 Array)   36499_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000271332
NCBI entrez gene - 1952     See in Manteia.
OMIM - 604265
RefSeq - NM_001408
RefSeq - XM_005270580
RefSeq Peptide - NP_001399
swissprot - Q9HCU4
Ensembl - ENSG00000143126
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 celsr2ENSDARG00000019726Danio rerio
 ENSGALG00000042961Gallus gallus
 Celsr2ENSMUSG00000068740Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CELSR1 / Q9NYQ6 / cadherin EGF LAG seven-pass G-type receptor 1ENSG0000007527557
CELSR3 / Q9NYQ7 / cadherin EGF LAG seven-pass G-type receptor 3ENSG0000000830053
FAT1 / Q14517 / FAT atypical cadherin 1ENSG0000008385720
DCHS1 / Q96JQ0 / dachsous cadherin-related 1ENSG0000016634119
FAT2 / Q9NYQ8 / FAT atypical cadherin 2ENSG0000008657019
FAT4 / Q6V0I7 / FAT atypical cadherin 4ENSG0000019615919
FAT3 / Q8TDW7 / FAT atypical cadherin 3ENSG0000016532319
CDH23 / Q9H251 / cadherin related 23ENSG0000010773610


Protein motifs (from Interpro)
Interpro ID Name
 IPR000152  EGF-type aspartate/asparagine hydroxylation site
 IPR000203  GPS motif
 IPR000742  EGF-like domain
 IPR000832  GPCR, family 2, secretin-like
 IPR001791  Laminin G domain
 IPR001879  GPCR, family 2, extracellular hormone receptor domain
 IPR001881  EGF-like calcium-binding domain
 IPR002049  Laminin EGF domain
 IPR002126  Cadherin
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR013032  EGF-like, conserved site
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily
 IPR015919  Cadherin-like
 IPR017981  GPCR, family 2-like
 IPR020894  Cadherin conserved site
 IPR032471  GAIN domain, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006355 regulation of transcription, DNA-templated ISS
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules ISS
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007166 cell surface receptor signaling pathway IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway NAS
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0016055 Wnt signaling pathway ISS
 biological_processGO:0021999 neural plate anterior/posterior regionalization ISS
 biological_processGO:0022407 regulation of cell-cell adhesion ISS
 biological_processGO:0048813 dendrite morphogenesis ISS
 biological_processGO:0060071 Wnt signaling pathway, planar cell polarity pathway NAS
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005886 plasma membrane ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane NAS
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity NAS
 molecular_functionGO:0005509 calcium ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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