ENSG00000160868


Homo sapiens

Features
Gene ID: ENSG00000160868
  
Biological name :CYP3A4
  
Synonyms : CYP3A4 / cytochrome P450 family 3 subfamily A member 4 / P08684
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: -1
Band: q22.1
Gene start: 99756960
Gene end: 99784265
  
Corresponding Affymetrix probe sets: 205998_x_at (Human Genome U133 Plus 2.0 Array)   205999_x_at (Human Genome U133 Plus 2.0 Array)   208367_x_at (Human Genome U133 Plus 2.0 Array)   210726_at (Human Genome U133 Plus 2.0 Array)   231704_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000346607
Ensembl peptide - ENSP00000397208
Ensembl peptide - ENSP00000337915
NCBI entrez gene - 1576     See in Manteia.
OMIM - 124010
RefSeq - XM_017011780
RefSeq - NM_001202855
RefSeq - NM_017460
RefSeq Peptide - NP_001189784
RefSeq Peptide - NP_059488
swissprot - C9JBD2
swissprot - P08684
swissprot - E7EVM8
swissprot - Q6GRK0
Ensembl - ENSG00000160868
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cyp3a65ENSDARG00000103295Danio rerio
 cyp3c1ENSDARG00000015575Danio rerio
 cyp3c2ENSDARG00000037874Danio rerio
 cyp3c3ENSDARG00000037873Danio rerio
 cyp3c4ENSDARG00000070021Danio rerio
 CYP3A5ENSGALG00000004449Gallus gallus
 Cyp3a44ENSMUSG00000054417Mus musculus
 Cyp3a57ENSMUSG00000070419Mus musculus
 Cyp3a59ENSMUSG00000061292Mus musculus
 O09158ENSMUSG00000029630Mus musculus
 Q64459ENSMUSG00000056035Mus musculus
 Q64464ENSMUSG00000029727Mus musculus
 Q64481ENSMUSG00000038656Mus musculus
 Q9JMA7ENSMUSG00000075552Mus musculus
 Q9JMA7ENSMUSG00000075551Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P24462 / CYP3A7-CYP3A51P / CYP3A7-CYP3A51P readthroughENSG0000028230188
CYP3A7 / P24462 / cytochrome P450 family 3 subfamily A member 7ENSG0000016087088
CYP3A5 / P20815 / cytochrome P450 family 3 subfamily A member 5ENSG0000010625884
Q9HB55 / CYP3A43 / cytochrome P450 family 3 subfamily A member 43ENSG0000002146176
P24557 / TBXAS1 / thromboxane A synthase 1ENSG0000005937738
Q9Y6A2 / CYP46A1 / cytochrome P450 family 46 subfamily A member 1ENSG0000003653024
Q02318 / CYP27A1 / cytochrome P450 family 27 subfamily A member 1ENSG0000013592924
O15528 / CYP27B1 / cytochrome P450 family 27 subfamily B member 1ENSG0000011101223
Q07973 / CYP24A1 / cytochrome P450 family 24 subfamily A member 1ENSG0000001918621
P05108 / CYP11A1 / cytochrome P450 family 11 subfamily A member 1ENSG0000014045920
P19099 / CYP11B2 / cytochrome P450 family 11 subfamily B member 2ENSG0000017914219
Q4G0S4 / CYP27C1 / cytochrome P450 family 27 subfamily C member 1ENSG0000018668419
P15538 / CYP11B1 / cytochrome P450 family 11 subfamily B member 1ENSG0000016088219


Protein motifs (from Interpro)
Interpro ID Name
 IPR001128  Cytochrome P450
 IPR002401  Cytochrome P450, E-class, group I
 IPR002402  Cytochrome P450, E-class, group II
 IPR008072  Cytochrome P450, E-class, CYP3A
 IPR017972  Cytochrome P450, conserved site
 IPR036396  Cytochrome P450 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002933 lipid hydroxylation IDA
 biological_processGO:0006629 lipid metabolic process TAS
 biological_processGO:0006706 steroid catabolic process IMP
 biological_processGO:0006805 xenobiotic metabolic process TAS
 biological_processGO:0008202 steroid metabolic process IMP
 biological_processGO:0008209 androgen metabolic process TAS
 biological_processGO:0009822 alkaloid catabolic process IDA
 biological_processGO:0016098 monoterpenoid metabolic process IDA
 biological_processGO:0017144 drug metabolic process IDA
 biological_processGO:0036378 calcitriol biosynthetic process from calciol IEA
 biological_processGO:0042359 vitamin D metabolic process IC
 biological_processGO:0042737 drug catabolic process IMP
 biological_processGO:0042738 exogenous drug catabolic process IDA
 biological_processGO:0046483 heterocycle metabolic process IDA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0070989 oxidative demethylation IDA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031090 organelle membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle TAS
 molecular_functionGO:0004497 monooxygenase activity IEA
 molecular_functionGO:0005496 steroid binding IDA
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0008395 steroid hydroxylase activity IMP
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
 molecular_functionGO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IEA
 molecular_functionGO:0019825 oxygen binding TAS
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0020037 heme binding IEA
 molecular_functionGO:0030343 vitamin D3 25-hydroxylase activity IDA
 molecular_functionGO:0034875 caffeine oxidase activity IDA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0050649 testosterone 6-beta-hydroxylase activity IMP
 molecular_functionGO:0070576 vitamin D 24-hydroxylase activity IDA
 molecular_functionGO:0101020 estrogen 16-alpha-hydroxylase activity IDA


Pathways (from Reactome)
Pathway description
Xenobiotics
Aflatoxin activation and detoxification
Biosynthesis of maresin-like SPMs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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