ENSG00000160870


Homo sapiens

Features
Gene ID: ENSG00000160870
  
Biological name :CYP3A7
  
Synonyms : CYP3A7 / cytochrome P450 family 3 subfamily A member 7 / P24462
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: -1
Band: q22.1
Gene start: 99684957
Gene end: 99735196
  
Corresponding Affymetrix probe sets: 205939_at (Human Genome U133 Plus 2.0 Array)   211843_x_at (Human Genome U133 Plus 2.0 Array)   243609_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000337450
Ensembl peptide - ENSP00000479282
NCBI entrez gene - 1551     See in Manteia.
OMIM - 605340
RefSeq - NM_000765
RefSeq Peptide - NP_000756
swissprot - A0A087WV96
swissprot - P24462
Ensembl - ENSG00000160870
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cyp3a65ENSDARG00000103295Danio rerio
 cyp3c1ENSDARG00000015575Danio rerio
 cyp3c2ENSDARG00000037874Danio rerio
 cyp3c3ENSDARG00000037873Danio rerio
 cyp3c4ENSDARG00000070021Danio rerio
 CYP3A5ENSGALG00000004449Gallus gallus
 Cyp3a44ENSMUSG00000054417Mus musculus
 Cyp3a57ENSMUSG00000070419Mus musculus
 Cyp3a59ENSMUSG00000061292Mus musculus
 O09158ENSMUSG00000029630Mus musculus
 Q64459ENSMUSG00000056035Mus musculus
 Q64464ENSMUSG00000029727Mus musculus
 Q64481ENSMUSG00000038656Mus musculus
 Q9JMA7ENSMUSG00000075552Mus musculus
 Q9JMA7ENSMUSG00000075551Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P24462 / CYP3A7-CYP3A51P / CYP3A7-CYP3A51P readthroughENSG0000028230199
CYP3A4 / P08684 / cytochrome P450 family 3 subfamily A member 4ENSG0000016086888
CYP3A5 / P20815 / cytochrome P450 family 3 subfamily A member 5ENSG0000010625882
Q9HB55 / CYP3A43 / cytochrome P450 family 3 subfamily A member 43ENSG0000002146171
P24557 / TBXAS1 / thromboxane A synthase 1ENSG0000005937736
Q02318 / CYP27A1 / cytochrome P450 family 27 subfamily A member 1ENSG0000013592923
Q9Y6A2 / CYP46A1 / cytochrome P450 family 46 subfamily A member 1ENSG0000003653023
O15528 / CYP27B1 / cytochrome P450 family 27 subfamily B member 1ENSG0000011101222
Q07973 / CYP24A1 / cytochrome P450 family 24 subfamily A member 1ENSG0000001918620
Q4G0S4 / CYP27C1 / cytochrome P450 family 27 subfamily C member 1ENSG0000018668419
P05108 / CYP11A1 / cytochrome P450 family 11 subfamily A member 1ENSG0000014045919
P19099 / CYP11B2 / cytochrome P450 family 11 subfamily B member 2ENSG0000017914219
P15538 / CYP11B1 / cytochrome P450 family 11 subfamily B member 1ENSG0000016088219


Protein motifs (from Interpro)
Interpro ID Name
 IPR001128  Cytochrome P450
 IPR002402  Cytochrome P450, E-class, group II
 IPR008072  Cytochrome P450, E-class, CYP3A
 IPR017972  Cytochrome P450, conserved site
 IPR036396  Cytochrome P450 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002933 lipid hydroxylation IDA
 biological_processGO:0006805 xenobiotic metabolic process TAS
 biological_processGO:0008202 steroid metabolic process IDA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031090 organelle membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0004497 monooxygenase activity IEA
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0008395 steroid hydroxylase activity IDA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
 molecular_functionGO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IEA
 molecular_functionGO:0019825 oxygen binding TAS
 molecular_functionGO:0020037 heme binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0070330 aromatase activity IEA
 molecular_functionGO:0101020 estrogen 16-alpha-hydroxylase activity IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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