ENSG00000170421


Homo sapiens

Features
Gene ID: ENSG00000170421
  
Biological name :KRT8
  
Synonyms : keratin 8 / KRT8 / P05787
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: -1
Band: q13.13
Gene start: 52897187
Gene end: 52949954
  
Corresponding Affymetrix probe sets: 209008_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000450228
Ensembl peptide - ENSP00000450340
Ensembl peptide - ENSP00000489174
Ensembl peptide - ENSP00000293308
Ensembl peptide - ENSP00000447040
Ensembl peptide - ENSP00000447402
Ensembl peptide - ENSP00000447566
Ensembl peptide - ENSP00000447881
Ensembl peptide - ENSP00000449010
Ensembl peptide - ENSP00000449404
NCBI entrez gene - 3856     See in Manteia.
OMIM - 148060
RefSeq - NM_001256293
RefSeq - NM_002273
RefSeq - NM_001256282
RefSeq Peptide - NP_001243211
RefSeq Peptide - NP_001243222
RefSeq Peptide - NP_002264
swissprot - A0A0U1RQU6
swissprot - P05787
swissprot - F8VP67
swissprot - F8VQY3
swissprot - F8VUG2
swissprot - F8W1U3
swissprot - H0YIB2
Ensembl - ENSG00000170421
  
Related genetic diseases (OMIM): 215600 - Cirrhosis, cryptogenic, 215600
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 krt4ENSDARG00000017624Danio rerio
 krt5ENSDARG00000058371Danio rerio
 krt8ENSDARG00000058358Danio rerio
 zgc:158846ENSDARG00000058462Danio rerio
 Krt8ENSMUSG00000049382Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
KRT5 / P13647 / keratin 5ENSG0000018608160
KRT6B / P04259 / keratin 6BENSG0000018547958
KRT6A / P02538 / keratin 6AENSG0000020542058
KRT75 / O95678 / keratin 75ENSG0000017045458
KRT6C / P48668 / keratin 6CENSG0000017046558
KRT3 / P12035 / keratin 3ENSG0000018644256
KRT7 / P08729 / keratin 7ENSG0000013548055
KRT76 / Q01546 / keratin 76ENSG0000018506955
KRT1 / P04264 / keratin 1ENSG0000016776854
KRT79 / Q5XKE5 / keratin 79ENSG0000018564051
KRT4 / P19013 / keratin 4ENSG0000017047751
KRT71 / Q3SY84 / keratin 71ENSG0000013964849


Protein motifs (from Interpro)
Interpro ID Name
 IPR001664  Intermediate filament protein
 IPR003054  Keratin, type II
 IPR018039  Intermediate filament protein, conserved site
 IPR032444  Keratin type II head


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0016032 viral process IEA
 biological_processGO:0031424 keratinization TAS
 biological_processGO:0033209 tumor necrosis factor-mediated signaling pathway IEA
 biological_processGO:0045214 sarcomere organization IEA
 biological_processGO:0051599 response to hydrostatic pressure IEA
 biological_processGO:0051707 response to other organism IEA
 biological_processGO:0060706 cell differentiation involved in embryonic placenta development IEA
 biological_processGO:0070268 cornification TAS
 biological_processGO:0097191 extrinsic apoptotic signaling pathway IEA
 biological_processGO:0097284 hepatocyte apoptotic process IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005882 intermediate filament IEA
 cellular_componentGO:0005911 cell-cell junction IEA
 cellular_componentGO:0016010 dystrophin-associated glycoprotein complex IEA
 cellular_componentGO:0016327 apicolateral plasma membrane IEA
 cellular_componentGO:0016363 nuclear matrix IEA
 cellular_componentGO:0030018 Z disc IEA
 cellular_componentGO:0042383 sarcolemma IEA
 cellular_componentGO:0043034 costamere IEA
 cellular_componentGO:0045095 keratin filament IEA
 cellular_componentGO:0045111 intermediate filament cytoskeleton IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0071944 cell periphery IEA
 molecular_functionGO:0005198 structural molecule activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0097110 scaffold protein binding IPI


Pathways (from Reactome)
Pathway description
Keratinization
Formation of the cornified envelope


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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