ENSG00000188229


Homo sapiens

Features
Gene ID: ENSG00000188229
  
Biological name :TUBB4B
  
Synonyms : P68371 / TUBB4B / tubulin beta 4B class IVb
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 9
Strand: 1
Band: q34.3
Gene start: 137241213
Gene end: 137243707
  
Corresponding Affymetrix probe sets: 208977_x_at (Human Genome U133 Plus 2.0 Array)   213726_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000341289
NCBI entrez gene - 10383     See in Manteia.
OMIM - 602660
RefSeq - NM_006088
RefSeq Peptide - NP_006079
swissprot - P68371
Ensembl - ENSG00000188229
  
Related genetic diseases (OMIM): 617879 - Leber congenital amaurosis with early-onset deafness, 617879
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 P68372ENSMUSG00000036752Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P04350 / TUBB4A / tubulin beta 4A class IVaENSG0000010483398
Q9BVA1 / TUBB2B / tubulin beta 2B class IIbENSG0000013728597
TUBB / P07437 / tubulin beta class IENSG0000019623097
Q13885 / TUBB2A / tubulin beta 2A class IIaENSG0000013726796
TUBB3 / Q13509 / tubulin beta 3 class IIIENSG0000025894793
TUBB8 / Q3ZCM7 / tubulin beta 8 class VIIIENSG0000026145691
TUBB6 / Q9BUF5 / tubulin beta 6 class VENSG0000017601491
AC092143.1ENSG0000019821190
A6NNZ2 / TUBB8P12 / tubulin beta 8 pseudogene 12ENSG0000017321389
TUBB1 / Q9H4B7 / tubulin beta 1 class VIENSG0000010116279
TUBE1 / Q9UJT0 / tubulin epsilon 1ENSG0000007493534
TUBD1 / Q9UJT1 / tubulin delta 1ENSG0000010842323
MC1R / Q01726 / melanocortin 1 receptorENSG000002588392


Protein motifs (from Interpro)
Interpro ID Name
 IPR000217  Tubulin
 IPR002453  Beta tubulin
 IPR003008  Tubulin/FtsZ, GTPase domain
 IPR008280  Tubulin/FtsZ, C-terminal
 IPR013838  Beta tubulin, autoregulation binding site
 IPR017975  Tubulin, conserved site
 IPR018316  Tubulin/FtsZ, 2-layer sandwich domain
 IPR036525  Tubulin/FtsZ, GTPase domain superfamily
 IPR037103  Tubulin/FtsZ, C-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000086 G2/M transition of mitotic cell cycle TAS
 biological_processGO:0007010 cytoskeleton organization IEA
 biological_processGO:0007017 microtubule-based process IEA
 biological_processGO:0010389 regulation of G2/M transition of mitotic cell cycle TAS
 biological_processGO:0042267 natural killer cell mediated cytotoxicity NAS
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0097711 ciliary basal body-plasma membrane docking TAS
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005634 nucleus HDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton TAS
 cellular_componentGO:0005874 microtubule IDA
 cellular_componentGO:0035578 azurophil granule lumen TAS
 cellular_componentGO:0043209 myelin sheath IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:1903561 extracellular vesicle HDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003725 double-stranded RNA binding IDA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0005200 structural constituent of cytoskeleton IEA
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0042288 MHC class I protein binding TAS
 molecular_functionGO:0051082 unfolded protein binding NAS


Pathways (from Reactome)
Pathway description
Translocation of SLC2A4 (GLUT4) to the plasma membrane
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane
Gap junction assembly
MHC class II antigen presentation
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
Regulation of PLK1 Activity at G2/M Transition
HSP90 chaperone cycle for steroid hormone receptors (SHR)
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Prefoldin mediated transfer of substrate to CCT/TriC
Formation of tubulin folding intermediates by CCT/TriC
Post-chaperonin tubulin folding pathway
Recycling pathway of L1
Hedgehog off state
Cilium Assembly
Anchoring of the basal body to the plasma membrane
Intraflagellar transport
RHO GTPases activate IQGAPs
RHO GTPases Activate Formins
Neutrophil degranulation
COPI-mediated anterograde transport
COPI-dependent Golgi-to-ER retrograde traffic
COPI-independent Golgi-to-ER retrograde traffic
Mitotic Prometaphase
The role of GTSE1 in G2/M progression after G2 checkpoint
AURKA Activation by TPX2
Carboxyterminal post-translational modifications of tubulin
Kinesins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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