ENSG00000176014


Homo sapiens

Features
Gene ID: ENSG00000176014
  
Biological name :TUBB6
  
Synonyms : Q9BUF5 / TUBB6 / tubulin beta 6 class V
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 18
Strand: 1
Band: p11.21
Gene start: 12307669
Gene end: 12344320
  
Corresponding Affymetrix probe sets: 209191_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000468820
Ensembl peptide - ENSP00000468571
Ensembl peptide - ENSP00000468777
Ensembl peptide - ENSP00000318697
Ensembl peptide - ENSP00000465040
Ensembl peptide - ENSP00000465386
Ensembl peptide - ENSP00000465448
Ensembl peptide - ENSP00000465891
Ensembl peptide - ENSP00000466849
Ensembl peptide - ENSP00000467348
Ensembl peptide - ENSP00000467969
Ensembl peptide - ENSP00000468179
NCBI entrez gene - 84617     See in Manteia.
OMIM - 615103
RefSeq - NM_001303525
RefSeq - NM_032525
RefSeq - NM_001303530
RefSeq - NM_001303529
RefSeq - NM_001303528
RefSeq - NM_001303527
RefSeq - NM_001303526
RefSeq - NM_001303524
RefSeq Peptide - NP_001290456
RefSeq Peptide - NP_001290453
RefSeq Peptide - NP_001290454
RefSeq Peptide - NP_001290455
RefSeq Peptide - NP_001290457
RefSeq Peptide - NP_001290458
RefSeq Peptide - NP_001290459
RefSeq Peptide - NP_115914
swissprot - K7EL29
swissprot - K7EK43
swissprot - K7EJZ4
swissprot - Q9BUF5
swissprot - K7EJ64
swissprot - K7ESM5
swissprot - K7ESQ3
swissprot - K7ES63
swissprot - K7ERA8
swissprot - K7EQT3
swissprot - K7EPE5
swissprot - K7EN98
Ensembl - ENSG00000176014
  
Related genetic diseases (OMIM): 617732 - ?Facial palsy, congenitla, with ptosis and velopharyngeal dysfunction, 617732
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tubb6ENSDARG00000104801Danio rerio
 TUBB6ENSGALG00000031275Gallus gallus
 Tubb6ENSMUSG00000001473Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P04350 / TUBB4A / tubulin beta 4A class IVaENSG0000010483392
TUBB3 / Q13509 / tubulin beta 3 class IIIENSG0000025894792
Q13885 / TUBB2A / tubulin beta 2A class IIaENSG0000013726791
Q9BVA1 / TUBB2B / tubulin beta 2B class IIbENSG0000013728591
P68371 / TUBB4B / tubulin beta 4B class IVbENSG0000018822991
TUBB / P07437 / tubulin beta class IENSG0000019623091
AC092143.1ENSG0000019821190
TUBB8 / Q3ZCM7 / tubulin beta 8 class VIIIENSG0000026145685
A6NNZ2 / TUBB8P12 / tubulin beta 8 pseudogene 12ENSG0000017321383
TUBB1 / Q9H4B7 / tubulin beta 1 class VIENSG0000010116278
TUBE1 / Q9UJT0 / tubulin epsilon 1ENSG0000007493533
TUBD1 / Q9UJT1 / tubulin delta 1ENSG0000010842321
MC1R / Q01726 / melanocortin 1 receptorENSG000002588392


Protein motifs (from Interpro)
Interpro ID Name
 IPR000217  Tubulin
 IPR002453  Beta tubulin
 IPR003008  Tubulin/FtsZ, GTPase domain
 IPR008280  Tubulin/FtsZ, C-terminal
 IPR013838  Beta tubulin, autoregulation binding site
 IPR017975  Tubulin, conserved site
 IPR018316  Tubulin/FtsZ, 2-layer sandwich domain
 IPR036525  Tubulin/FtsZ, GTPase domain superfamily
 IPR037103  Tubulin/FtsZ, C-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007010 cytoskeleton organization IEA
 biological_processGO:0007017 microtubule-based process IEA
 cellular_componentGO:0005634 nucleus HDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0005200 structural constituent of cytoskeleton IEA
 molecular_functionGO:0005525 GTP binding IEA


Pathways (from Reactome)
Pathway description
Translocation of SLC2A4 (GLUT4) to the plasma membrane
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane
Gap junction assembly
MHC class II antigen presentation
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
HSP90 chaperone cycle for steroid hormone receptors (SHR)
Recruitment of NuMA to mitotic centrosomes
Prefoldin mediated transfer of substrate to CCT/TriC
Formation of tubulin folding intermediates by CCT/TriC
Post-chaperonin tubulin folding pathway
Recycling pathway of L1
Hedgehog off state
Cilium Assembly
Intraflagellar transport
RHO GTPases activate IQGAPs
RHO GTPases Activate Formins
COPI-mediated anterograde transport
COPI-dependent Golgi-to-ER retrograde traffic
COPI-independent Golgi-to-ER retrograde traffic
Mitotic Prometaphase
The role of GTSE1 in G2/M progression after G2 checkpoint
Carboxyterminal post-translational modifications of tubulin
Kinesins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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