ENSG00000204642


Homo sapiens

Features
Gene ID: ENSG00000204642
  
Biological name :HLA-F
  
Synonyms : HLA-F / major histocompatibility complex, class I, F / P30511
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: 1
Band: p22.1
Gene start: 29722775
Gene end: 29738528
  
Corresponding Affymetrix probe sets: 204806_x_at (Human Genome U133 Plus 2.0 Array)   221875_x_at (Human Genome U133 Plus 2.0 Array)   221978_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000397376
Ensembl peptide - ENSP00000392251
Ensembl peptide - ENSP00000486309
Ensembl peptide - ENSP00000486947
Ensembl peptide - ENSP00000259951
Ensembl peptide - ENSP00000334263
Ensembl peptide - ENSP00000366057
NCBI entrez gene - 3134     See in Manteia.
OMIM - 143110
RefSeq - XM_017010815
RefSeq - NM_001098478
RefSeq - NM_001098479
RefSeq - NM_018950
RefSeq - XM_011514564
RefSeq - XM_017010810
RefSeq - XM_017010811
RefSeq - XM_017010812
RefSeq - XM_017010813
RefSeq - XM_017010814
RefSeq Peptide - NP_001091949
RefSeq Peptide - NP_061823
RefSeq Peptide - NP_001091948
swissprot - Q5JZ48
swissprot - A0A0D9SF55
swissprot - A0A0D9SFW8
swissprot - P30511
swissprot - H0Y4J4
swissprot - Q5JZ47
Ensembl - ENSG00000204642
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Gm11127ENSMUSG00000079492Mus musculus
 Gm7030ENSMUSG00000092243Mus musculus
 Gm8909ENSMUSG00000073402Mus musculus
 H2-BlENSMUSG00000073406Mus musculus
 H2-D1ENSMUSG00000073411Mus musculus
 H2-K1ENSMUSG00000061232Mus musculus
 H2-M1ENSMUSG00000037334Mus musculus
 H2-M11ENSMUSG00000037537Mus musculus
 H2-M2ENSMUSG00000016283Mus musculus
 H2-M3ENSMUSG00000016206Mus musculus
 H2-M5ENSMUSG00000024459Mus musculus
 H2-M9ENSMUSG00000067201Mus musculus
 H2-Q1ENSMUSG00000079507Mus musculus
 H2-Q10ENSMUSG00000067235Mus musculus
 H2-Q2ENSMUSG00000091705Mus musculus
 H2-Q4ENSMUSG00000035929Mus musculus
 H2-Q5ENSMUSG00000055413Mus musculus
 H2-Q6ENSMUSG00000073409Mus musculus
 H2-Q7ENSMUSG00000060550Mus musculus
 H2-T23ENSMUSG00000067212Mus musculus
 H2-T3ENSMUSG00000054128Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
HLA-A / P04439 / P13746 / P16188 / major histocompatibility complex, class I, AENSG0000020650364
HLA-B / P30480 / P30486 / Q29836 / Q31610 / Q31612 / P01889 / major histocompatibility complex, class I, BENSG0000023474563
HLA-C / P10321 / major histocompatibility complex, class I, CENSG0000020452562
HLA-G / P17693 / major histocompatibility complex, class I, GENSG0000020463260
HLA-E / major histocompatibility complex, class I, EENSG0000020459258


Protein motifs (from Interpro)
Interpro ID Name
 IPR001039  MHC class I alpha chain, alpha1 alpha2 domains
 IPR003006  Immunoglobulin/major histocompatibility complex, conserved site
 IPR003597  Immunoglobulin C1-set
 IPR007110  Immunoglobulin-like domain
 IPR011161  MHC class I-like antigen recognition-like
 IPR011162  MHC classes I/II-like antigen recognition protein
 IPR013783  Immunoglobulin-like fold
 IPR021157  Cytochrome c1, transmembrane anchor, C-terminal
 IPR036179  Immunoglobulin-like domain superfamily
 IPR037055  MHC class I-like antigen recognition-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002474 antigen processing and presentation of peptide antigen via MHC class I IBA
 biological_processGO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS
 biological_processGO:0002480 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent TAS
 biological_processGO:0050776 regulation of immune response TAS
 biological_processGO:0060333 interferon-gamma-mediated signaling pathway TAS
 biological_processGO:0060337 type I interferon signaling pathway TAS
 cellular_componentGO:0000139 Golgi membrane TAS
 cellular_componentGO:0005783 endoplasmic reticulum IDA
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0012507 ER to Golgi transport vesicle membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030670 phagocytic vesicle membrane TAS
 cellular_componentGO:0031901 early endosome membrane TAS
 cellular_componentGO:0042612 MHC class I protein complex IEA
 cellular_componentGO:0055038 recycling endosome membrane TAS
 cellular_componentGO:0071556 integral component of lumenal side of endoplasmic reticulum membrane TAS
 molecular_functionGO:0005102 signaling receptor binding IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042605 peptide antigen binding IBA
 molecular_functionGO:0046978 TAP1 binding IPI
 molecular_functionGO:0046979 TAP2 binding IPI


Pathways (from Reactome)
Pathway description
ER-Phagosome pathway
Endosomal/Vacuolar pathway
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Interferon gamma signaling
Interferon alpha/beta signaling
Antigen Presentation: Folding, assembly and peptide loading of class I MHC


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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