Manteia

ENSMUSG00000016206

Mus musculus

Features

Gene ID:	ENSMUSG00000016206

Biological name :	H2-M3

Synonyms :	H2-M3

Possible biological names infered from orthology :	HLA-A / HLA-B / HLA-C / HLA-E / HLA-F / HLA-G / major histocompatibility complex, class I, A / major histocompatibility complex, class I, B / major histocompatibility complex, class I, C / major histocompatibility complex, class I, E / major histocompatibility complex, class I, F / major histocompatibility complex, class I, G / P01889 / P04439 / P10321 / P13746 / P16188 / P17693 / P30480 / P30486 / P30511 / Q29836 / Q31610 / Q31612

Species:	Mus musculus

Chr. number:	17
Strand:	1
Band:	B1
Gene start:	37270220
Gene end:	37274484

Corresponding Affymetrix probe sets:	10445119 (MoGene1.0st) 1421358_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000035687 NCBI entrez gene - 14991 See in Manteia. MGI - MGI:95915 RefSeq - NM_013819 RefSeq Peptide - NP_038847 swissprot - Q31093 Ensembl - ENSMUSG00000016206

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
HLA-A	ENSG00000206503	Homo sapiens
HLA-B	ENSG00000234745	Homo sapiens
HLA-C	ENSG00000204525	Homo sapiens
HLA-E	ENSG00000204592	Homo sapiens
HLA-F	ENSG00000204642	Homo sapiens
HLA-G	ENSG00000204632	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
H2-T23 / P06339 / H-2 class I histocompatibility antigen, D-37 alpha chain / HLA-B* / HLA-C* / HLA-A* / HLA-F* / HLA-G* / HLA-E* / Q31612* / P17693* / P30480* / P30486* / P30511* / Q29836*...	ENSMUSG00000067212	61
H2-Q2 / histocompatibility 2, Q region locus 2 / HLA-A* / HLA-B* / HLA-C* / HLA-E* / HLA-F* / HLA-G* / Q31612* / P17693* / P30480* / P30486* / P30511* / Q29836* / Q31610* / P01889* / P04439...	ENSMUSG00000091705	61
H2-D1 / P01899 / H-2 class I histocompatibility antigen, D-B alpha chain / HLA-B* / HLA-C* / HLA-A* / HLA-F* / HLA-G* / HLA-E* / Q31612* / P17693* / P30480* / P30486* / P30511* / Q29836* /...	ENSMUSG00000073411	61
Gm8909 / HLA-A* / HLA-B* / HLA-C* / HLA-E* / HLA-F* / HLA-G* / Q31612* / P17693* / P30480* / P30486* / P30511* / Q29836* / Q31610* / P01889* / P04439* / P10321* / P13746* / P16188* / major ...	ENSMUSG00000073402	60
H2-Q7 / P14429 / Mus musculus histocompatibility 2, Q region locus 9 (H2-Q9), mRNA. / HLA-B* / HLA-E* / HLA-F* / HLA-G* / HLA-C* / HLA-A* / Q31612* / P17693* / P30480* / P30486* / P30511* /...	ENSMUSG00000060550	60
H2-K1 / P01901 / histocompatibility 2, K1, K region / HLA-B* / HLA-C* / HLA-A* / HLA-F* / HLA-G* / HLA-E* / Q31612* / P17693* / P30480* / P30486* / P30511* / Q29836* / Q31610* / P01889* / P...	ENSMUSG00000061232	60
Gm11127 / HLA-A* / HLA-B* / HLA-C* / HLA-E* / HLA-F* / HLA-G* / Q31612* / P17693* / P30480* / P30486* / P30511* / Q29836* / Q31610* / P01889* / P04439* / P10321* / P13746* / P16188* / major...	ENSMUSG00000079492	59
H2-Q1 / Mus musculus histocompatibility 2, Q region locus 1 (H2-Q1), transcript variant 2, mRNA. / HLA-B* / HLA-C* / HLA-E* / HLA-F* / HLA-G* / HLA-A* / Q31612* / P17693* / P30480* / P30486...	ENSMUSG00000079507	59
H2-Q10 / P01898 / H-2 class I histocompatibility antigen, Q10 alpha chain / HLA-B* / HLA-C* / HLA-A* / HLA-F* / HLA-G* / HLA-E* / Q31612* / P17693* / P30480* / P30486* / P30511* / Q29836* ...	ENSMUSG00000067235	59
H2-Q6 / histocompatibility 2, Q region locus 6 / HLA-A* / HLA-B* / HLA-C* / HLA-E* / HLA-F* / HLA-G* / Q31612* / P17693* / P30480* / P30486* / P30511* / Q29836* / Q31610* / P01889* / P04439...	ENSMUSG00000073409	58
H2-Q4 / HLA-A* / HLA-B* / HLA-C* / HLA-E* / HLA-F* / HLA-G* / Q31612* / P17693* / P30480* / P30486* / P30511* / Q29836* / Q31610* / P01889* / P04439* / P10321* / P13746* / P16188* / major h...	ENSMUSG00000035929	57
H2-M2 / Mus musculus histocompatibility 2, M region locus 2 (H2-M2), transcript variant 2, mRNA. / HLA-B* / HLA-C* / HLA-E* / HLA-F* / HLA-G* / HLA-A* / Q31612* / P17693* / P30480* / P30486...	ENSMUSG00000016283	54
Gm7030 / HLA-A* / HLA-B* / HLA-C* / HLA-E* / HLA-F* / HLA-G* / Q31612* / P17693* / P30480* / P30486* / P30511* / Q29836* / Q31610* / P01889* / P04439* / P10321* / P13746* / P16188* / major ...	ENSMUSG00000092243	53
H2-T3 / histocompatibility 2, T region locus 3 / HLA-A* / HLA-B* / HLA-C* / HLA-E* / HLA-F* / HLA-G* / Q31612* / P17693* / P30480* / P30486* / P30511* / Q29836* / Q31610* / P01889* / P04439...	ENSMUSG00000054128	53
H2-M5 / HLA-A* / HLA-B* / HLA-C* / HLA-E* / HLA-F* / HLA-G* / Q31612* / P17693* / P30480* / P30486* / P30511* / Q29836* / Q31610* / P01889* / P04439* / P10321* / P13746* / P16188* / major h...	ENSMUSG00000024459	52
H2-M1 / HLA-A* / HLA-B* / HLA-C* / HLA-E* / HLA-F* / HLA-G* / Q31612* / P17693* / P30480* / P30486* / P30511* / Q29836* / Q31610* / P01889* / P04439* / P10321* / P13746* / P16188* / major h...	ENSMUSG00000037334	42
H2-M11 / histocompatibility 2, M region locus 11 / HLA-A* / HLA-B* / HLA-C* / HLA-E* / HLA-F* / HLA-G* / Q31612* / P17693* / P30480* / P30486* / P30511* / Q29836* / Q31610* / P01889* / P04...	ENSMUSG00000037537	41
H2-M9 / histocompatibility 2, M region locus 9 / HLA-A* / HLA-B* / HLA-C* / HLA-E* / HLA-F* / HLA-G* / Q31612* / P17693* / P30480* / P30486* / P30511* / Q29836* / Q31610* / P01889* / P04439...	ENSMUSG00000067201	40
H2-Q5 / HLA-A* / HLA-B* / HLA-C* / HLA-E* / HLA-F* / HLA-G* / Q31612* / P17693* / P30480* / P30486* / P30511* / Q29836* / Q31610* / P01889* / P04439* / P10321* / P13746* / P16188* / major h...	ENSMUSG00000055413	35
H2-Bl / histocompatibility 2, blastocyst / HLA-A* / HLA-B* / HLA-C* / HLA-E* / HLA-F* / HLA-G* / Q31612* / P17693* / P30480* / P30486* / P30511* / Q29836* / Q31610* / P01889* / P04439* / P...	ENSMUSG00000073406	32

Protein motifs (from Interpro)

Interpro ID	Name
IPR001039	MHC class I alpha chain, alpha1 alpha2 domains
IPR003006	Immunoglobulin/major histocompatibility complex, conserved site
IPR003597	Immunoglobulin C1-set
IPR007110	Immunoglobulin-like domain
IPR011161	MHC class I-like antigen recognition-like
IPR011162	MHC classes I/II-like antigen recognition protein
IPR013783	Immunoglobulin-like fold
IPR036179	Immunoglobulin-like domain superfamily
IPR037055	MHC class I-like antigen recognition-like superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0001916	positive regulation of T cell mediated cytotoxicity	IMP
biological_process	GO:0002237	response to molecule of bacterial origin	IDA
biological_process	GO:0002287	alpha-beta T cell activation involved in immune response	IMP
biological_process	GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	IBA
biological_process	GO:0002476	antigen processing and presentation of endogenous peptide antigen via MHC class Ib	IDA
biological_process	GO:0002477	antigen processing and presentation of exogenous peptide antigen via MHC class Ib	IDA
biological_process	GO:0002481	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent	IDA
biological_process	GO:0002645	positive regulation of tolerance induction	ISO
biological_process	GO:0002666	positive regulation of T cell tolerance induction	ISO
biological_process	GO:0002767	immune response-inhibiting cell surface receptor signaling pathway	ISO
biological_process	GO:0032729	positive regulation of interferon-gamma production	IMP
biological_process	GO:0032735	positive regulation of interleukin-12 production	ISO
biological_process	GO:0042130	negative regulation of T cell proliferation	ISO
biological_process	GO:0042742	defense response to bacterium	IMP
biological_process	GO:0045429	positive regulation of nitric oxide biosynthetic process	IMP
biological_process	GO:0045591	positive regulation of regulatory T cell differentiation	ISO
biological_process	GO:0045954	positive regulation of natural killer cell mediated cytotoxicity	IMP
biological_process	GO:2001199	negative regulation of dendritic cell differentiation	ISO
cellular_component	GO:0009897	external side of plasma membrane	IDA
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0016021	integral component of membrane	IEA
cellular_component	GO:0032398	MHC class Ib protein complex	IDA
molecular_function	GO:0005102	signaling receptor binding	IBA
molecular_function	GO:0042605	peptide antigen binding	IMP
molecular_function	GO:0042802	identical protein binding	ISO
molecular_function	GO:0042803	protein homodimerization activity	ISO

Pathways (from Reactome)

Pathway description

ER-Phagosome pathway

Endosomal/Vacuolar pathway

Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Neutrophil degranulation

Antigen Presentation: Folding, assembly and peptide loading of class I MHC

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0001830	decreased activated T cell number	"reduced numbers of effector T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Ptges3^{Gt(W069F07)Wrst}/Ptges3^{Gt(W069F07)Wrst} Genetic Background: involves: 129X1/SvJ * C57BL/6
MP:0002412	increased susceptibility to bacterial infection	"greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Ptges3^{Gt(W069F07)Wrst}/Ptges3^{Gt(W069F07)Wrst} Genetic Background: involves: 129X1/SvJ * C57BL/6
MP:0002419	abnormal innate immunity	"anomaly in the function of the early phase of the response to infection; normally, it is present at all times, does not increase with exposure to specific pathogens, and does not discriminate between pathogens" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Ptges3^{Gt(W069F07)Wrst}/Ptges3^{Gt(W069F07)Wrst} Genetic Background: involves: 129X1/SvJ * C57BL/6
MP:0005010	abnormal CD8+ T cell morphology/development	"anomalous structure, formation, or numbers of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Ptges3^{Gt(W069F07)Wrst}/Ptges3^{Gt(W069F07)Wrst} Genetic Background: involves: 129X1/SvJ * C57BL/6
MP:0005070	defective NK cell cytolysis	"impaired ability of these cells to destroy or dissolve targeted cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:6213]	Show Allelic Composition: Ptges3^{Gt(W069F07)Wrst}/Ptges3^{Gt(W069F07)Wrst} Genetic Background: involves: 129X1/SvJ * C57BL/6
MP:0005078	abnormal cytotoxic T cell physiology	"impaired function of the subset of CD8+ T lymphocytes capable of directly killing appropriately targeted cells " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Ptges3^{Gt(W069F07)Wrst}/Ptges3^{Gt(W069F07)Wrst} Genetic Background: involves: 129X1/SvJ * C57BL/6
MP:0008567	decreased interferon-gamma secretion	"reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]	Show Allelic Composition: Ptges3^{Gt(W069F07)Wrst}/Ptges3^{Gt(W069F07)Wrst} Genetic Background: involves: 129X1/SvJ * C57BL/6
MP:0011077	decreased macrophage nitric oxide production	"reduced production of macrophage-derived nitric oxide due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ptges3^{Gt(W069F07)Wrst}/Ptges3^{Gt(W069F07)Wrst} Genetic Background: involves: 129X1/SvJ * C57BL/6

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

1 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr