ENSMUSG00000073411


Mus musculus

Features
Gene ID: ENSMUSG00000073411
  
Biological name :H2-D1
  
Synonyms : H-2 class I histocompatibility antigen, D-B alpha chain / H2-D1 / P01899
  
Possible biological names infered from orthology : HLA-A / HLA-B / HLA-C / HLA-E / HLA-F / HLA-G / major histocompatibility complex, class I, A / major histocompatibility complex, class I, B / major histocompatibility complex, class I, C / major histocompatibility complex, class I, E / major histocompatibility complex, class I, F / major histocompatibility complex, class I, G / P01889 / P04439 / P10321 / P13746 / P16188 / P17693 / P30480 / P30486 / P30511 / Q29836 / Q31610 / Q31612
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: B1
Gene start: 35262730
Gene end: 35267499
  
Corresponding Affymetrix probe sets: 10444780 (MoGene1.0st)   1424948_x_at (Mouse Genome 430 2.0 Array)   1425545_x_at (Mouse Genome 430 2.0 Array)   1425614_x_at (Mouse Genome 430 2.0 Array)   1426324_at (Mouse Genome 430 2.0 Array)   1427651_x_at (Mouse Genome 430 2.0 Array)   1450170_x_at (Mouse Genome 430 2.0 Array)   1451683_x_at (Mouse Genome 430 2.0 Array)   1451784_x_at (Mouse Genome 430 2.0 Array)   1451931_x_at (Mouse Genome 430 2.0 Array)   1451934_at (Mouse Genome 430 2.0 Array)   1452544_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000133518
Ensembl peptide - ENSMUSP00000134570
Ensembl peptide - ENSMUSP00000134582
NCBI entrez gene - 14964     See in Manteia.
MGI - MGI:95896
RefSeq - NM_010380
RefSeq Peptide - NP_034510
swissprot - Q792Z7
swissprot - G3UX20
swissprot - G3UZP7
swissprot - P01899
Ensembl - ENSMUSG00000073411
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 HLA-AENSG00000206503Homo sapiens
 HLA-BENSG00000234745Homo sapiens
 HLA-CENSG00000204525Homo sapiens
 HLA-EENSG00000204592Homo sapiens
 HLA-FENSG00000204642Homo sapiens
 HLA-GENSG00000204632Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
H2-K1 / P01901 / histocompatibility 2, K1, K region / HLA-B* / HLA-C* / HLA-A* / HLA-F* / HLA-G* / HLA-E* / Q31612* / P17693* / P30480* / P30486* / P30511* / Q29836* / Q31610* / P01889* / P...ENSMUSG0000006123283
Gm8909 / HLA-A* / HLA-B* / HLA-C* / HLA-E* / HLA-F* / HLA-G* / Q31612* / P17693* / P30480* / P30486* / P30511* / Q29836* / Q31610* / P01889* / P04439* / P10321* / P13746* / P16188* / major ...ENSMUSG0000007340279
H2-Q1 / Mus musculus histocompatibility 2, Q region locus 1 (H2-Q1), transcript variant 2, mRNA. / HLA-B* / HLA-C* / HLA-E* / HLA-F* / HLA-G* / HLA-A* / Q31612* / P17693* / P30480* / P30486...ENSMUSG0000007950777
H2-Q7 / P14429 / Mus musculus histocompatibility 2, Q region locus 9 (H2-Q9), mRNA. / HLA-B* / HLA-E* / HLA-F* / HLA-G* / HLA-C* / HLA-A* / Q31612* / P17693* / P30480* / P30486* / P30511* /...ENSMUSG0000006055074
H2-Q10 / P01898 / H-2 class I histocompatibility antigen, Q10 alpha chain / HLA-B* / HLA-C* / HLA-A* / HLA-F* / HLA-G* / HLA-E* / Q31612* / P17693* / P30480* / P30486* / P30511* / Q29836* ...ENSMUSG0000006723573
H2-Q2 / histocompatibility 2, Q region locus 2 / HLA-A* / HLA-B* / HLA-C* / HLA-E* / HLA-F* / HLA-G* / Q31612* / P17693* / P30480* / P30486* / P30511* / Q29836* / Q31610* / P01889* / P04439...ENSMUSG0000009170573
H2-Q6 / histocompatibility 2, Q region locus 6 / HLA-A* / HLA-B* / HLA-C* / HLA-E* / HLA-F* / HLA-G* / Q31612* / P17693* / P30480* / P30486* / P30511* / Q29836* / Q31610* / P01889* / P04439...ENSMUSG0000007340972
H2-Q4 / HLA-A* / HLA-B* / HLA-C* / HLA-E* / HLA-F* / HLA-G* / Q31612* / P17693* / P30480* / P30486* / P30511* / Q29836* / Q31610* / P01889* / P04439* / P10321* / P13746* / P16188* / major h...ENSMUSG0000003592971
H2-T23 / P06339 / H-2 class I histocompatibility antigen, D-37 alpha chain / HLA-B* / HLA-C* / HLA-A* / HLA-F* / HLA-G* / HLA-E* / Q31612* / P17693* / P30480* / P30486* / P30511* / Q29836*...ENSMUSG0000006721270
Gm11127 / HLA-A* / HLA-B* / HLA-C* / HLA-E* / HLA-F* / HLA-G* / Q31612* / P17693* / P30480* / P30486* / P30511* / Q29836* / Q31610* / P01889* / P04439* / P10321* / P13746* / P16188* / major...ENSMUSG0000007949262
H2-T3 / histocompatibility 2, T region locus 3 / HLA-A* / HLA-B* / HLA-C* / HLA-E* / HLA-F* / HLA-G* / Q31612* / P17693* / P30480* / P30486* / P30511* / Q29836* / Q31610* / P01889* / P04439...ENSMUSG0000005412860
H2-M3 / HLA-A* / HLA-B* / HLA-C* / HLA-E* / HLA-F* / HLA-G* / Q31612* / P17693* / P30480* / P30486* / P30511* / Q29836* / Q31610* / P01889* / P04439* / P10321* / P13746* / P16188* / major h...ENSMUSG0000001620657
H2-M2 / Mus musculus histocompatibility 2, M region locus 2 (H2-M2), transcript variant 2, mRNA. / HLA-B* / HLA-C* / HLA-E* / HLA-F* / HLA-G* / HLA-A* / Q31612* / P17693* / P30480* / P30486...ENSMUSG0000001628356
Gm7030 / HLA-A* / HLA-B* / HLA-C* / HLA-E* / HLA-F* / HLA-G* / Q31612* / P17693* / P30480* / P30486* / P30511* / Q29836* / Q31610* / P01889* / P04439* / P10321* / P13746* / P16188* / major ...ENSMUSG0000009224353
H2-M5 / HLA-A* / HLA-B* / HLA-C* / HLA-E* / HLA-F* / HLA-G* / Q31612* / P17693* / P30480* / P30486* / P30511* / Q29836* / Q31610* / P01889* / P04439* / P10321* / P13746* / P16188* / major h...ENSMUSG0000002445951
H2-Bl / histocompatibility 2, blastocyst / HLA-A* / HLA-B* / HLA-C* / HLA-E* / HLA-F* / HLA-G* / Q31612* / P17693* / P30480* / P30486* / P30511* / Q29836* / Q31610* / P01889* / P04439* / P...ENSMUSG0000007340647
H2-Q5 / HLA-A* / HLA-B* / HLA-C* / HLA-E* / HLA-F* / HLA-G* / Q31612* / P17693* / P30480* / P30486* / P30511* / Q29836* / Q31610* / P01889* / P04439* / P10321* / P13746* / P16188* / major h...ENSMUSG0000005541345
H2-M1 / HLA-A* / HLA-B* / HLA-C* / HLA-E* / HLA-F* / HLA-G* / Q31612* / P17693* / P30480* / P30486* / P30511* / Q29836* / Q31610* / P01889* / P04439* / P10321* / P13746* / P16188* / major h...ENSMUSG0000003733444
H2-M11 / histocompatibility 2, M region locus 11 / HLA-A* / HLA-B* / HLA-C* / HLA-E* / HLA-F* / HLA-G* / Q31612* / P17693* / P30480* / P30486* / P30511* / Q29836* / Q31610* / P01889* / P04...ENSMUSG0000003753741
H2-M9 / histocompatibility 2, M region locus 9 / HLA-A* / HLA-B* / HLA-C* / HLA-E* / HLA-F* / HLA-G* / Q31612* / P17693* / P30480* / P30486* / P30511* / Q29836* / Q31610* / P01889* / P04439...ENSMUSG0000006720140


Protein motifs (from Interpro)
Interpro ID Name
 IPR001039  MHC class I alpha chain, alpha1 alpha2 domains
 IPR003006  Immunoglobulin/major histocompatibility complex, conserved site
 IPR003597  Immunoglobulin C1-set
 IPR007110  Immunoglobulin-like domain
 IPR010579  MHC class I, alpha chain, C-terminal
 IPR011161  MHC class I-like antigen recognition-like
 IPR011162  MHC classes I/II-like antigen recognition protein
 IPR013783  Immunoglobulin-like fold
 IPR036179  Immunoglobulin-like domain superfamily
 IPR037055  MHC class I-like antigen recognition-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001916 positive regulation of T cell mediated cytotoxicity IDA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002474 antigen processing and presentation of peptide antigen via MHC class I IEA
 biological_processGO:0002485 antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent IDA
 biological_processGO:0006955 immune response IEA
 biological_processGO:0010977 negative regulation of neuron projection development IMP
 biological_processGO:0019882 antigen processing and presentation IEA
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:0005794 Golgi apparatus ISO
 cellular_componentGO:0005797 Golgi medial cisterna ISO
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0009986 cell surface ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030670 phagocytic vesicle membrane TAS
 cellular_componentGO:0042612 MHC class I protein complex IEA
 cellular_componentGO:0070971 endoplasmic reticulum exit site ISO
 cellular_componentGO:0071556 integral component of lumenal side of endoplasmic reticulum membrane TAS
 molecular_functionGO:0005102 signaling receptor binding ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0030881 beta-2-microglobulin binding ISO
 molecular_functionGO:0042605 peptide antigen binding ISO
 molecular_functionGO:0042608 T cell receptor binding ISO
 molecular_functionGO:0046977 TAP binding ISO


Pathways (from Reactome)
Pathway description
ER-Phagosome pathway
Endosomal/Vacuolar pathway
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Neutrophil degranulation
Antigen Presentation: Folding, assembly and peptide loading of class I MHC


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000727 absent CD4-8+ cells "lack of the set of single-positive T cells that express CD8 on their surface" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: NOD.129S7(B6)-Ifngtm1Ts/DvsJ

 MP:0000921 demyelination "loss of the myelin sheath without loss of axons or fiber tracts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Dicer1tm1Gz/Dicer1tm1Gz
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Apelatm1.2Brre/Apela+
Genetic Background: B6(Cg)-Apelatm1.2Brre

Allelic Composition: H2-D1em1Dvs/H2-D1em1Dvs
Genetic Background: NOD/ShiLtDvs-H2-D1em1Dvs/Dvs

Allelic Composition: H2-D1em2Dvs/H2-D1em2Dvs
Genetic Background: NOD/ShiLtDvs-H2-D1em2Dvs/Dvs

Allelic Composition: H2-D1em3Dvs/H2-D1em3Dvs
Genetic Background: NOD/ShiLtDvs-H2-D1em3Dvs/Dvs

 MP:0001828 abnormal T cell activation "anomaly in the process of producing effector T cells from naive T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Dicer1tm1Gz/Dicer1tm1Gz
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001844 autoimmune response "condition in which cells and/or antibodies arise from and are directed against one s own tissues " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: H2-D1em5Dvs/H2-D1em5Dvs,H2-K1em1Dvs/H2-K1em1Dvs
Genetic Background: NOD/ShiLtDvs-H2-K1em1Dvs H2-D1em5Dvs/Dvs

Allelic Composition: H2-D1em5Dvs/H2-D1em5Dvs,H2-K1em1Dvs/H2-K1em1Dvs,Tg(HLA-A/H2-D/B2M)1Dvs/?
Genetic Background: NOD/ShiLtDvs-H2-K1em1Dvs H2-D1em5Dvs Tg(HLA-A/H2-D/B2M)1Dvs/Dvs

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Lifrtm1Imx/Lifr+
Genetic Background: B6;129S7-Lifrtm1Imx/J

 MP:0002886 abnormal glutamate receptor currents "change in the measured amplitude or duration of response to stimulation of glutmanergic receptors" [Principles of Neural Science, 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: NOD.129S7(B6)-Ifngtm1Ts/DvsJ

 MP:0002916 increased synaptic depression "increase in the duration of the reduction of effectiveness of synaptic connections between neurons and target after repetitive stimulation" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: NOD.129S7(B6)-Ifngtm1Ts/DvsJ

 MP:0002919 enhanced paired-pulse facilitation "increase in the response of central synapses when activated twice in rapid succession; indicative of defects in short-term plasticity due to greater increase of neurotransmitter release at the second stimulus" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: NOD.129S7(B6)-Ifngtm1Ts/DvsJ

 MP:0003858 enhanced coordination "improved ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: NOD.129S7(B6)-Ifngtm1Ts/DvsJ

 MP:0003944 abnormal T cell subpopulation ratio "deviation from the standard ratios of T cell subpopulations (e.g. double positive to single positive ratio) compared to control samples" [mberry:Melissa Berry, Genetics Resources Curator]
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Allelic Composition: Tmem30atm1.1Xjz/Tmem30atm1.1Xjz,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6J * DBA

Allelic Composition: H2-Ab1em1Dvs/H2-Ab1em1Dvs,H2-D1em5Dvs/H2-D1em5Dvs,H2-K1em1Dvs/H2-K1em1Dvs
Genetic Background: NOD/ShiLtDvs-H2-K1em1Dvs H2-Ab1em1Dvs H2-D1em5Dvs/Dvs

 MP:0004031 insulitis "a histologic change in the islets of Langerhans characterized by edema and the infiltration of small numbers of white blood cells" [rbabiuk:Randall Babiuk, Mouse Genome Informatics Curator]
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Allelic Composition: H2-D1em5Dvs/H2-D1em5Dvs,H2-K1em1Dvs/H2-K1em1Dvs
Genetic Background: NOD/ShiLtDvs-H2-K1em1Dvs H2-D1em5Dvs/Dvs

Allelic Composition: H2-D1em5Dvs/H2-D1em5Dvs,H2-K1em1Dvs/H2-K1em1Dvs,Tg(HLA-A/H2-D/B2M)1Dvs/?
Genetic Background: NOD/ShiLtDvs-H2-K1em1Dvs H2-D1em5Dvs Tg(HLA-A/H2-D/B2M)1Dvs/Dvs

 MP:0004801 increased susceptibility to systemic lupus erythematosus "greater likelihood that an organism will develop inflammatory connective tissue symptoms characteristic of lupus including skin rash, arthritis and inflammation of different organs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lifrtm1Imx/Lifr+
Genetic Background: B6;129S7-Lifrtm1Imx/J

 MP:0004803 increased susceptibility to autoimmune diabetes "greater likelihood that an organism will develop inflammatory pancreatic disease resulting from the body attacking and destroying the insulin-producing beta islet cells of the pancreas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: H2-D1em5Dvs/H2-D1em5Dvs,H2-K1em1Dvs/H2-K1em1Dvs
Genetic Background: NOD/ShiLtDvs-H2-K1em1Dvs H2-D1em5Dvs/Dvs

Allelic Composition: H2-D1em5Dvs/H2-D1em5Dvs,H2-K1em1Dvs/H2-K1em1Dvs,Tg(HLA-A/H2-D/B2M)1Dvs/?
Genetic Background: NOD/ShiLtDvs-H2-K1em1Dvs H2-D1em5Dvs Tg(HLA-A/H2-D/B2M)1Dvs/Dvs

 MP:0004804 decreased susceptibility to autoimmune diabetes "reduced likelihood that an organism will develop inflammatory pancreatic disease resulting from the body attacking and destroying the insulin-producing beta islet cells of the pancreas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Apelatm1.2Brre/Apela+
Genetic Background: B6(Cg)-Apelatm1.2Brre

Allelic Composition: H2-D1em1Dvs/H2-D1em1Dvs
Genetic Background: NOD/ShiLtDvs-H2-D1em1Dvs/Dvs

Allelic Composition: H2-D1em2Dvs/H2-D1em2Dvs
Genetic Background: NOD/ShiLtDvs-H2-D1em2Dvs/Dvs

Allelic Composition: H2-D1em3Dvs/H2-D1em3Dvs
Genetic Background: NOD/ShiLtDvs-H2-D1em3Dvs/Dvs

Allelic Composition: H2-D1em5Dvs/H2-D1em5Dvs,H2-K1em1Dvs/H2-K1em1Dvs
Genetic Background: NOD/ShiLtDvs-H2-K1em1Dvs H2-D1em5Dvs/Dvs

Allelic Composition: H2-Ab1em1Dvs/H2-Ab1em1Dvs,H2-D1em5Dvs/H2-D1em5Dvs,H2-K1em1Dvs/H2-K1em1Dvs
Genetic Background: NOD/ShiLtDvs-H2-K1em1Dvs H2-Ab1em1Dvs H2-D1em5Dvs/Dvs

 MP:0005078 abnormal cytotoxic T cell physiology "impaired function of the subset of CD8+ T lymphocytes capable of directly killing appropriately targeted cells " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ptges3Gt(W069F07)Wrst/Ptges3Gt(W069F07)Wrst
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0006082 CNS inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the brain and/or spinal cord" [smb:Susan M Bello, Mouse Genome Informatics Curator, ncbi:NCBI request]
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Allelic Composition: Dicer1tm1Gz/Dicer1tm1Gz
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008074 increased CD4-positive T cell number "greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: H2-D1tm1Bpe/H2-D1tm1Bpe,H2-K1tm1Bpe/H2-K1tm1Bpe
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: H2-Ab1em1Dvs/H2-Ab1em1Dvs,H2-D1em5Dvs/H2-D1em5Dvs,H2-K1em1Dvs/H2-K1em1Dvs
Genetic Background: NOD/ShiLtDvs-H2-K1em1Dvs H2-Ab1em1Dvs H2-D1em5Dvs/Dvs

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: H2-D1tm1Bpe/H2-D1tm1Bpe,H2-K1tm1Bpe/H2-K1tm1Bpe
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: B2mtm1Unc/B2mtm1Unc,H2-D1tm1Bpe/H2-D1tm1Bpe
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009790 decreased susceptibility to viral infection induced morbidity/mortality "reduced likelihood that an organism will display the expected moribund state caused by a viral invasion or from components of or toxins produced by a virus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: H2-D1tm1Bpe/H2-D1tm1Bpe,H2-K1tm1Bpe/H2-K1tm1Bpe
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0012765 decreased alpha-beta T cell number "reduced number of T cells that expresses an alpha-beta T cell receptor complex" [CL:0000789]
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Allelic Composition: H2-Ab1em1Dvs/H2-Ab1em1Dvs,H2-D1em5Dvs/H2-D1em5Dvs,H2-K1em1Dvs/H2-K1em1Dvs
Genetic Background: NOD/ShiLtDvs-H2-K1em1Dvs H2-Ab1em1Dvs H2-D1em5Dvs/Dvs

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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