ENSMUSG00000061232


Mus musculus

Features
Gene ID: ENSMUSG00000061232
  
Biological name :H2-K1
  
Synonyms : H2-K1 / histocompatibility 2, K1, K region / P01901
  
Possible biological names infered from orthology : HLA-A / HLA-B / HLA-C / HLA-E / HLA-F / HLA-G / major histocompatibility complex, class I, A / major histocompatibility complex, class I, B / major histocompatibility complex, class I, C / major histocompatibility complex, class I, E / major histocompatibility complex, class I, F / major histocompatibility complex, class I, G / P01889 / P04439 / P10321 / P13746 / P16188 / P17693 / P30480 / P30486 / P30511 / Q29836 / Q31610 / Q31612
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: B1
Gene start: 33996017
Gene end: 34000333
  
Corresponding Affymetrix probe sets: 10450075 (MoGene1.0st)   1425336_x_at (Mouse Genome 430 2.0 Array)   1427746_x_at (Mouse Genome 430 2.0 Array)   1450534_x_at (Mouse Genome 430 2.0 Array)   1451593_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000025181
Ensembl peptide - ENSMUSP00000084436
Ensembl peptide - ENSMUSP00000133847
Ensembl peptide - ENSMUSP00000134004
NCBI entrez gene - 14972     See in Manteia.
MGI - MGI:95904
RefSeq - XM_017317259
RefSeq - XM_006523674
RefSeq - XM_006523676
RefSeq - XM_006523677
RefSeq - XM_006523678
RefSeq - XM_006523680
RefSeq - XM_017317257
RefSeq - XM_017317258
RefSeq - NM_001001892
RefSeq - NM_001347346
RefSeq - XM_006523673
RefSeq Peptide - NP_001001892
RefSeq Peptide - NP_001334275
swissprot - A0A0B4J1G3
swissprot - G3UXW2
swissprot - Q3TH01
swissprot - P01901
swissprot - Q7JJ15
Ensembl - ENSMUSG00000061232
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 HLA-AENSG00000206503Homo sapiens
 HLA-BENSG00000234745Homo sapiens
 HLA-CENSG00000204525Homo sapiens
 HLA-EENSG00000204592Homo sapiens
 HLA-FENSG00000204642Homo sapiens
 HLA-GENSG00000204632Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
H2-D1 / P01899 / H-2 class I histocompatibility antigen, D-B alpha chain / HLA-B* / HLA-C* / HLA-A* / HLA-F* / HLA-G* / HLA-E* / Q31612* / P17693* / P30480* / P30486* / P30511* / Q29836* /...ENSMUSG0000007341182
Gm8909 / HLA-A* / HLA-B* / HLA-C* / HLA-E* / HLA-F* / HLA-G* / Q31612* / P17693* / P30480* / P30486* / P30511* / Q29836* / Q31610* / P01889* / P04439* / P10321* / P13746* / P16188* / major ...ENSMUSG0000007340274
H2-Q1 / Mus musculus histocompatibility 2, Q region locus 1 (H2-Q1), transcript variant 2, mRNA. / HLA-B* / HLA-C* / HLA-E* / HLA-F* / HLA-G* / HLA-A* / Q31612* / P17693* / P30480* / P30486...ENSMUSG0000007950772
H2-Q7 / P14429 / Mus musculus histocompatibility 2, Q region locus 9 (H2-Q9), mRNA. / HLA-B* / HLA-E* / HLA-F* / HLA-G* / HLA-C* / HLA-A* / Q31612* / P17693* / P30480* / P30486* / P30511* /...ENSMUSG0000006055071
H2-T23 / P06339 / H-2 class I histocompatibility antigen, D-37 alpha chain / HLA-B* / HLA-C* / HLA-A* / HLA-F* / HLA-G* / HLA-E* / Q31612* / P17693* / P30480* / P30486* / P30511* / Q29836*...ENSMUSG0000006721271
H2-Q2 / histocompatibility 2, Q region locus 2 / HLA-A* / HLA-B* / HLA-C* / HLA-E* / HLA-F* / HLA-G* / Q31612* / P17693* / P30480* / P30486* / P30511* / Q29836* / Q31610* / P01889* / P04439...ENSMUSG0000009170571
H2-Q10 / P01898 / H-2 class I histocompatibility antigen, Q10 alpha chain / HLA-B* / HLA-C* / HLA-A* / HLA-F* / HLA-G* / HLA-E* / Q31612* / P17693* / P30480* / P30486* / P30511* / Q29836* ...ENSMUSG0000006723570
H2-Q4 / HLA-A* / HLA-B* / HLA-C* / HLA-E* / HLA-F* / HLA-G* / Q31612* / P17693* / P30480* / P30486* / P30511* / Q29836* / Q31610* / P01889* / P04439* / P10321* / P13746* / P16188* / major h...ENSMUSG0000003592970
H2-Q6 / histocompatibility 2, Q region locus 6 / HLA-A* / HLA-B* / HLA-C* / HLA-E* / HLA-F* / HLA-G* / Q31612* / P17693* / P30480* / P30486* / P30511* / Q29836* / Q31610* / P01889* / P04439...ENSMUSG0000007340969
Gm11127 / HLA-A* / HLA-B* / HLA-C* / HLA-E* / HLA-F* / HLA-G* / Q31612* / P17693* / P30480* / P30486* / P30511* / Q29836* / Q31610* / P01889* / P04439* / P10321* / P13746* / P16188* / major...ENSMUSG0000007949261
H2-T3 / histocompatibility 2, T region locus 3 / HLA-A* / HLA-B* / HLA-C* / HLA-E* / HLA-F* / HLA-G* / Q31612* / P17693* / P30480* / P30486* / P30511* / Q29836* / Q31610* / P01889* / P04439...ENSMUSG0000005412860
H2-M2 / Mus musculus histocompatibility 2, M region locus 2 (H2-M2), transcript variant 2, mRNA. / HLA-B* / HLA-C* / HLA-E* / HLA-F* / HLA-G* / HLA-A* / Q31612* / P17693* / P30480* / P30486...ENSMUSG0000001628355
H2-M3 / HLA-A* / HLA-B* / HLA-C* / HLA-E* / HLA-F* / HLA-G* / Q31612* / P17693* / P30480* / P30486* / P30511* / Q29836* / Q31610* / P01889* / P04439* / P10321* / P13746* / P16188* / major h...ENSMUSG0000001620654
Gm7030 / HLA-A* / HLA-B* / HLA-C* / HLA-E* / HLA-F* / HLA-G* / Q31612* / P17693* / P30480* / P30486* / P30511* / Q29836* / Q31610* / P01889* / P04439* / P10321* / P13746* / P16188* / major ...ENSMUSG0000009224352
H2-M5 / HLA-A* / HLA-B* / HLA-C* / HLA-E* / HLA-F* / HLA-G* / Q31612* / P17693* / P30480* / P30486* / P30511* / Q29836* / Q31610* / P01889* / P04439* / P10321* / P13746* / P16188* / major h...ENSMUSG0000002445950
H2-Q5 / HLA-A* / HLA-B* / HLA-C* / HLA-E* / HLA-F* / HLA-G* / Q31612* / P17693* / P30480* / P30486* / P30511* / Q29836* / Q31610* / P01889* / P04439* / P10321* / P13746* / P16188* / major h...ENSMUSG0000005541345
H2-M1 / HLA-A* / HLA-B* / HLA-C* / HLA-E* / HLA-F* / HLA-G* / Q31612* / P17693* / P30480* / P30486* / P30511* / Q29836* / Q31610* / P01889* / P04439* / P10321* / P13746* / P16188* / major h...ENSMUSG0000003733444
H2-Bl / histocompatibility 2, blastocyst / HLA-A* / HLA-B* / HLA-C* / HLA-E* / HLA-F* / HLA-G* / Q31612* / P17693* / P30480* / P30486* / P30511* / Q29836* / Q31610* / P01889* / P04439* / P...ENSMUSG0000007340643
H2-M11 / histocompatibility 2, M region locus 11 / HLA-A* / HLA-B* / HLA-C* / HLA-E* / HLA-F* / HLA-G* / Q31612* / P17693* / P30480* / P30486* / P30511* / Q29836* / Q31610* / P01889* / P04...ENSMUSG0000003753740
H2-M9 / histocompatibility 2, M region locus 9 / HLA-A* / HLA-B* / HLA-C* / HLA-E* / HLA-F* / HLA-G* / Q31612* / P17693* / P30480* / P30486* / P30511* / Q29836* / Q31610* / P01889* / P04439...ENSMUSG0000006720140


Protein motifs (from Interpro)
Interpro ID Name
 IPR001039  MHC class I alpha chain, alpha1 alpha2 domains
 IPR003006  Immunoglobulin/major histocompatibility complex, conserved site
 IPR003597  Immunoglobulin C1-set
 IPR007110  Immunoglobulin-like domain
 IPR010579  MHC class I, alpha chain, C-terminal
 IPR011161  MHC class I-like antigen recognition-like
 IPR011162  MHC classes I/II-like antigen recognition protein
 IPR013783  Immunoglobulin-like fold
 IPR036179  Immunoglobulin-like domain superfamily
 IPR037055  MHC class I-like antigen recognition-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001916 positive regulation of T cell mediated cytotoxicity IDA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002474 antigen processing and presentation of peptide antigen via MHC class I IEA
 biological_processGO:0002485 antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent IDA
 biological_processGO:0006955 immune response IEA
 biological_processGO:0010977 negative regulation of neuron projection development IMP
 biological_processGO:0019882 antigen processing and presentation IEA
 biological_processGO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I IDA
 biological_processGO:0042742 defense response to bacterium IDA
 biological_processGO:0048839 inner ear development IDA
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:0005794 Golgi apparatus ISO
 cellular_componentGO:0005797 Golgi medial cisterna ISO
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0009986 cell surface ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030670 phagocytic vesicle membrane TAS
 cellular_componentGO:0042612 MHC class I protein complex IEA
 cellular_componentGO:0070971 endoplasmic reticulum exit site ISO
 cellular_componentGO:0071556 integral component of lumenal side of endoplasmic reticulum membrane TAS
 molecular_functionGO:0005102 signaling receptor binding IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0030881 beta-2-microglobulin binding ISO
 molecular_functionGO:0042605 peptide antigen binding ISO
 molecular_functionGO:0042608 T cell receptor binding ISO
 molecular_functionGO:0046977 TAP binding ISO


Pathways (from Reactome)
Pathway description
ER-Phagosome pathway
Endosomal/Vacuolar pathway
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Neutrophil degranulation
Antigen Presentation: Folding, assembly and peptide loading of class I MHC


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000727 absent CD4-8+ cells "lack of the set of single-positive T cells that express CD8 on their surface" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: NOD.129S7(B6)-Ifngtm1Ts/DvsJ

 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Apelatm1.2Brre/Apela+
Genetic Background: B6(Cg)-Apelatm1.2Brre

Allelic Composition: H2-K1em5Dvs/H2-K1em5Dvs
Genetic Background: NOD/ShiLtDvs-H2-K1em5Dvs/Dvs

Allelic Composition: H2-K1em7Dvs/H2-K1em7Dvs
Genetic Background: NOD/ShiLtDvs-H2-K1em7Dvs/Dvs

 MP:0001844 autoimmune response "condition in which cells and/or antibodies arise from and are directed against one s own tissues " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: H2-D1em5Dvs/H2-D1em5Dvs,H2-K1em1Dvs/H2-K1em1Dvs
Genetic Background: NOD/ShiLtDvs-H2-K1em1Dvs H2-D1em5Dvs/Dvs

Allelic Composition: H2-D1em5Dvs/H2-D1em5Dvs,H2-K1em1Dvs/H2-K1em1Dvs,Tg(HLA-A/H2-D/B2M)1Dvs/?
Genetic Background: NOD/ShiLtDvs-H2-K1em1Dvs H2-D1em5Dvs Tg(HLA-A/H2-D/B2M)1Dvs/Dvs

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Lifrtm1Imx/Lifr+
Genetic Background: B6;129S7-Lifrtm1Imx/J

 MP:0002886 abnormal glutamate receptor currents "change in the measured amplitude or duration of response to stimulation of glutmanergic receptors" [Principles of Neural Science, 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: NOD.129S7(B6)-Ifngtm1Ts/DvsJ

 MP:0002916 increased synaptic depression "increase in the duration of the reduction of effectiveness of synaptic connections between neurons and target after repetitive stimulation" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: NOD.129S7(B6)-Ifngtm1Ts/DvsJ

 MP:0002919 enhanced paired-pulse facilitation "increase in the response of central synapses when activated twice in rapid succession; indicative of defects in short-term plasticity due to greater increase of neurotransmitter release at the second stimulus" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: NOD.129S7(B6)-Ifngtm1Ts/DvsJ

 MP:0003858 enhanced coordination "improved ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: NOD.129S7(B6)-Ifngtm1Ts/DvsJ

 MP:0003944 abnormal T cell subpopulation ratio "deviation from the standard ratios of T cell subpopulations (e.g. double positive to single positive ratio) compared to control samples" [mberry:Melissa Berry, Genetics Resources Curator]
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Allelic Composition: Tmem30atm1.1Xjz/Tmem30atm1.1Xjz,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6J * DBA

Allelic Composition: H2-Ab1em1Dvs/H2-Ab1em1Dvs,H2-D1em5Dvs/H2-D1em5Dvs,H2-K1em1Dvs/H2-K1em1Dvs
Genetic Background: NOD/ShiLtDvs-H2-K1em1Dvs H2-Ab1em1Dvs H2-D1em5Dvs/Dvs

 MP:0004031 insulitis "a histologic change in the islets of Langerhans characterized by edema and the infiltration of small numbers of white blood cells" [rbabiuk:Randall Babiuk, Mouse Genome Informatics Curator]
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Allelic Composition: H2-D1em5Dvs/H2-D1em5Dvs,H2-K1em1Dvs/H2-K1em1Dvs
Genetic Background: NOD/ShiLtDvs-H2-K1em1Dvs H2-D1em5Dvs/Dvs

Allelic Composition: H2-D1em5Dvs/H2-D1em5Dvs,H2-K1em1Dvs/H2-K1em1Dvs,Tg(HLA-A/H2-D/B2M)1Dvs/?
Genetic Background: NOD/ShiLtDvs-H2-K1em1Dvs H2-D1em5Dvs Tg(HLA-A/H2-D/B2M)1Dvs/Dvs

 MP:0004801 increased susceptibility to systemic lupus erythematosus "greater likelihood that an organism will develop inflammatory connective tissue symptoms characteristic of lupus including skin rash, arthritis and inflammation of different organs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lifrtm1Imx/Lifr+
Genetic Background: B6;129S7-Lifrtm1Imx/J

 MP:0004803 increased susceptibility to autoimmune diabetes "greater likelihood that an organism will develop inflammatory pancreatic disease resulting from the body attacking and destroying the insulin-producing beta islet cells of the pancreas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: H2-D1em5Dvs/H2-D1em5Dvs,H2-K1em1Dvs/H2-K1em1Dvs
Genetic Background: NOD/ShiLtDvs-H2-K1em1Dvs H2-D1em5Dvs/Dvs

Allelic Composition: H2-D1em5Dvs/H2-D1em5Dvs,H2-K1em1Dvs/H2-K1em1Dvs,Tg(HLA-A/H2-D/B2M)1Dvs/?
Genetic Background: NOD/ShiLtDvs-H2-K1em1Dvs H2-D1em5Dvs Tg(HLA-A/H2-D/B2M)1Dvs/Dvs

 MP:0004804 decreased susceptibility to autoimmune diabetes "reduced likelihood that an organism will develop inflammatory pancreatic disease resulting from the body attacking and destroying the insulin-producing beta islet cells of the pancreas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Apelatm1.2Brre/Apela+
Genetic Background: B6(Cg)-Apelatm1.2Brre

Allelic Composition: H2-K1em5Dvs/H2-K1em5Dvs
Genetic Background: NOD/ShiLtDvs-H2-K1em5Dvs/Dvs

Allelic Composition: H2-K1em7Dvs/H2-K1em7Dvs
Genetic Background: NOD/ShiLtDvs-H2-K1em7Dvs/Dvs

Allelic Composition: H2-D1em5Dvs/H2-D1em5Dvs,H2-K1em1Dvs/H2-K1em1Dvs
Genetic Background: NOD/ShiLtDvs-H2-K1em1Dvs H2-D1em5Dvs/Dvs

Allelic Composition: H2-Ab1em1Dvs/H2-Ab1em1Dvs,H2-D1em5Dvs/H2-D1em5Dvs,H2-K1em1Dvs/H2-K1em1Dvs
Genetic Background: NOD/ShiLtDvs-H2-K1em1Dvs H2-Ab1em1Dvs H2-D1em5Dvs/Dvs

 MP:0005078 abnormal cytotoxic T cell physiology "impaired function of the subset of CD8+ T lymphocytes capable of directly killing appropriately targeted cells " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ptges3Gt(W069F07)Wrst/Ptges3Gt(W069F07)Wrst
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0008074 increased CD4-positive T cell number "greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: NOD.129S7(B6)-Ifngtm1Ts/DvsJ

Allelic Composition: H2-D1tm1Bpe/H2-D1tm1Bpe,H2-K1tm1Bpe/H2-K1tm1Bpe
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: H2-Ab1em1Dvs/H2-Ab1em1Dvs,H2-D1em5Dvs/H2-D1em5Dvs,H2-K1em1Dvs/H2-K1em1Dvs
Genetic Background: NOD/ShiLtDvs-H2-K1em1Dvs H2-Ab1em1Dvs H2-D1em5Dvs/Dvs

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: NOD.129S7(B6)-Ifngtm1Ts/DvsJ

Allelic Composition: H2-D1tm1Bpe/H2-D1tm1Bpe,H2-K1tm1Bpe/H2-K1tm1Bpe
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009790 decreased susceptibility to viral infection induced morbidity/mortality "reduced likelihood that an organism will display the expected moribund state caused by a viral invasion or from components of or toxins produced by a virus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: H2-D1tm1Bpe/H2-D1tm1Bpe,H2-K1tm1Bpe/H2-K1tm1Bpe
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0012765 decreased alpha-beta T cell number "reduced number of T cells that expresses an alpha-beta T cell receptor complex" [CL:0000789]
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Allelic Composition: H2-Ab1em1Dvs/H2-Ab1em1Dvs,H2-D1em5Dvs/H2-D1em5Dvs,H2-K1em1Dvs/H2-K1em1Dvs
Genetic Background: NOD/ShiLtDvs-H2-K1em1Dvs H2-Ab1em1Dvs H2-D1em5Dvs/Dvs

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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