ENSMUSG00000054128


Mus musculus

Features
Gene ID: ENSMUSG00000054128
  
Biological name :H2-T3
  
Synonyms : H2-T3 / histocompatibility 2, T region locus 3
  
Possible biological names infered from orthology : HLA-A / HLA-B / HLA-C / HLA-E / HLA-F / HLA-G / major histocompatibility complex, class I, A / major histocompatibility complex, class I, B / major histocompatibility complex, class I, C / major histocompatibility complex, class I, E / major histocompatibility complex, class I, F / major histocompatibility complex, class I, G / P01889 / P04439 / P10321 / P13746 / P16188 / P17693 / P30480 / P30486 / P30511 / Q29836 / Q31610 / Q31612
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: B1
Gene start: 36185572
Gene end: 36190287
  
Corresponding Affymetrix probe sets: 10450735 (MoGene1.0st)   1427726_at (Mouse Genome 430 2.0 Array)   1452547_s_at (Mouse Genome 430 2.0 Array)   1452548_x_at (Mouse Genome 430 2.0 Array)   1460418_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000138563
Ensembl peptide - ENSMUSP00000138582
Ensembl peptide - ENSMUSP00000025312
Ensembl peptide - ENSMUSP00000099736
Ensembl peptide - ENSMUSP00000134469
Ensembl peptide - ENSMUSP00000134547
Ensembl peptide - ENSMUSP00000134607
Ensembl peptide - ENSMUSP00000138177
NCBI entrez gene - 15033     See in Manteia.
NCBI entrez gene - 15043     See in Manteia.
MGI - MGI:95959
RefSeq - XM_006537455
RefSeq - NM_008208
RefSeq Peptide - NP_032234
swissprot - F6TIX5
swissprot - Q05A75
swissprot - S4R1D6
swissprot - S4R2A2
swissprot - S4R2B8
swissprot - G3UZL7
swissprot - G3UZR8
Ensembl - ENSMUSG00000054128
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 HLA-AENSG00000206503Homo sapiens
 HLA-BENSG00000234745Homo sapiens
 HLA-CENSG00000204525Homo sapiens
 HLA-EENSG00000204592Homo sapiens
 HLA-FENSG00000204642Homo sapiens
 HLA-GENSG00000204632Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
H2-K1 / P01901 / histocompatibility 2, K1, K region / HLA-B* / HLA-C* / HLA-A* / HLA-F* / HLA-G* / HLA-E* / Q31612* / P17693* / P30480* / P30486* / P30511* / Q29836* / Q31610* / P01889* / P...ENSMUSG0000006123258
H2-D1 / P01899 / H-2 class I histocompatibility antigen, D-B alpha chain / HLA-B* / HLA-C* / HLA-A* / HLA-F* / HLA-G* / HLA-E* / Q31612* / P17693* / P30480* / P30486* / P30511* / Q29836* /...ENSMUSG0000007341156
H2-Q1 / Mus musculus histocompatibility 2, Q region locus 1 (H2-Q1), transcript variant 2, mRNA. / HLA-B* / HLA-C* / HLA-E* / HLA-F* / HLA-G* / HLA-A* / Q31612* / P17693* / P30480* / P30486...ENSMUSG0000007950756
H2-Q10 / P01898 / H-2 class I histocompatibility antigen, Q10 alpha chain / HLA-B* / HLA-C* / HLA-A* / HLA-F* / HLA-G* / HLA-E* / Q31612* / P17693* / P30480* / P30486* / P30511* / Q29836* ...ENSMUSG0000006723556
Gm11127 / HLA-A* / HLA-B* / HLA-C* / HLA-E* / HLA-F* / HLA-G* / Q31612* / P17693* / P30480* / P30486* / P30511* / Q29836* / Q31610* / P01889* / P04439* / P10321* / P13746* / P16188* / major...ENSMUSG0000007949255
Gm8909 / HLA-A* / HLA-B* / HLA-C* / HLA-E* / HLA-F* / HLA-G* / Q31612* / P17693* / P30480* / P30486* / P30511* / Q29836* / Q31610* / P01889* / P04439* / P10321* / P13746* / P16188* / major ...ENSMUSG0000007340255
H2-Q2 / histocompatibility 2, Q region locus 2 / HLA-A* / HLA-B* / HLA-C* / HLA-E* / HLA-F* / HLA-G* / Q31612* / P17693* / P30480* / P30486* / P30511* / Q29836* / Q31610* / P01889* / P04439...ENSMUSG0000009170554
H2-Q7 / P14429 / Mus musculus histocompatibility 2, Q region locus 9 (H2-Q9), mRNA. / HLA-B* / HLA-E* / HLA-F* / HLA-G* / HLA-C* / HLA-A* / Q31612* / P17693* / P30480* / P30486* / P30511* /...ENSMUSG0000006055054
H2-Q4 / HLA-A* / HLA-B* / HLA-C* / HLA-E* / HLA-F* / HLA-G* / Q31612* / P17693* / P30480* / P30486* / P30511* / Q29836* / Q31610* / P01889* / P04439* / P10321* / P13746* / P16188* / major h...ENSMUSG0000003592953
H2-Q6 / histocompatibility 2, Q region locus 6 / HLA-A* / HLA-B* / HLA-C* / HLA-E* / HLA-F* / HLA-G* / Q31612* / P17693* / P30480* / P30486* / P30511* / Q29836* / Q31610* / P01889* / P04439...ENSMUSG0000007340953
H2-T23 / P06339 / H-2 class I histocompatibility antigen, D-37 alpha chain / HLA-B* / HLA-C* / HLA-A* / HLA-F* / HLA-G* / HLA-E* / Q31612* / P17693* / P30480* / P30486* / P30511* / Q29836*...ENSMUSG0000006721253
H2-M2 / Mus musculus histocompatibility 2, M region locus 2 (H2-M2), transcript variant 2, mRNA. / HLA-B* / HLA-C* / HLA-E* / HLA-F* / HLA-G* / HLA-A* / Q31612* / P17693* / P30480* / P30486...ENSMUSG0000001628349
H2-M3 / HLA-A* / HLA-B* / HLA-C* / HLA-E* / HLA-F* / HLA-G* / Q31612* / P17693* / P30480* / P30486* / P30511* / Q29836* / Q31610* / P01889* / P04439* / P10321* / P13746* / P16188* / major h...ENSMUSG0000001620646
Gm7030 / HLA-A* / HLA-B* / HLA-C* / HLA-E* / HLA-F* / HLA-G* / Q31612* / P17693* / P30480* / P30486* / P30511* / Q29836* / Q31610* / P01889* / P04439* / P10321* / P13746* / P16188* / major ...ENSMUSG0000009224346
H2-M5 / HLA-A* / HLA-B* / HLA-C* / HLA-E* / HLA-F* / HLA-G* / Q31612* / P17693* / P30480* / P30486* / P30511* / Q29836* / Q31610* / P01889* / P04439* / P10321* / P13746* / P16188* / major h...ENSMUSG0000002445943
H2-M1 / HLA-A* / HLA-B* / HLA-C* / HLA-E* / HLA-F* / HLA-G* / Q31612* / P17693* / P30480* / P30486* / P30511* / Q29836* / Q31610* / P01889* / P04439* / P10321* / P13746* / P16188* / major h...ENSMUSG0000003733440
H2-M11 / histocompatibility 2, M region locus 11 / HLA-A* / HLA-B* / HLA-C* / HLA-E* / HLA-F* / HLA-G* / Q31612* / P17693* / P30480* / P30486* / P30511* / Q29836* / Q31610* / P01889* / P04...ENSMUSG0000003753739
H2-M9 / histocompatibility 2, M region locus 9 / HLA-A* / HLA-B* / HLA-C* / HLA-E* / HLA-F* / HLA-G* / Q31612* / P17693* / P30480* / P30486* / P30511* / Q29836* / Q31610* / P01889* / P04439...ENSMUSG0000006720138
H2-Q5 / HLA-A* / HLA-B* / HLA-C* / HLA-E* / HLA-F* / HLA-G* / Q31612* / P17693* / P30480* / P30486* / P30511* / Q29836* / Q31610* / P01889* / P04439* / P10321* / P13746* / P16188* / major h...ENSMUSG0000005541332
H2-Bl / histocompatibility 2, blastocyst / HLA-A* / HLA-B* / HLA-C* / HLA-E* / HLA-F* / HLA-G* / Q31612* / P17693* / P30480* / P30486* / P30511* / Q29836* / Q31610* / P01889* / P04439* / P...ENSMUSG0000007340630


Protein motifs (from Interpro)
Interpro ID Name
 IPR001039  MHC class I alpha chain, alpha1 alpha2 domains
 IPR003006  Immunoglobulin/major histocompatibility complex, conserved site
 IPR003597  Immunoglobulin C1-set
 IPR007110  Immunoglobulin-like domain
 IPR011161  MHC class I-like antigen recognition-like
 IPR011162  MHC classes I/II-like antigen recognition protein
 IPR013783  Immunoglobulin-like fold
 IPR036179  Immunoglobulin-like domain superfamily
 IPR037055  MHC class I-like antigen recognition-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA


Pathways (from Reactome)
Pathway description
ER-Phagosome pathway
Endosomal/Vacuolar pathway
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Neutrophil degranulation
Antigen Presentation: Folding, assembly and peptide loading of class I MHC


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lama4tm1Ktry/Lama4tm1Ktry,Lama5tm2Jhm/Lama5tm2Jhm,Tg(ACTA1-cre)1Mll/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm6.1(CAG-tdTomato)Maoh/Gt(ROSA)26Sortm6.1(CAG-tdTomato)Maoh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: H2-T3tm2.1(CAG-EGFP)Maoh/H2-T3tm2.1(CAG-EGFP)Maoh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002816 colitis "local accumulation of fluid, plasma proteins, and leukocytes in the colon region of the large intestine" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Lama4tm1Ktry/Lama4tm1Ktry,Lama5tm2Jhm/Lama5tm2Jhm,Tg(ACTA1-cre)1Mll/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008361 abnormal CD8-positive, gamma-delta intraepithelial T cell morphology "any structural anomaly of a CD8-positive, gamma-delta T cell of the columnar epithelia such as in the gastrointestinal tract; intraepithelial T cells often have distinct developmental pathways and activation requirements" [CL:0000803, ISBN:0781735149]
Show

Allelic Composition: Lama4tm1Ktry/Lama4tm1Ktry,Lama5tm2Jhm/Lama5tm2Jhm,Tg(ACTA1-cre)1Mll/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008401 abnormal CD8 positive, alpha-beta intraepithelial T cell morphology "any structural anomaly of a CD8-positive, alpha-beta T cell of the columnar epithelia such as in the gastrointestinal tract; intraepithelial T cells often have distinct developmental pathways and activation requirements" [ISBN:0781735149]
Show

Allelic Composition: Lama4tm1Ktry/Lama4tm1Ktry,Lama5tm2Jhm/Lama5tm2Jhm,Tg(ACTA1-cre)1Mll/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008466 enlarged mesenteric lymph nodes "increased size of the lymph nodes located in the mesentary, of which there are 3 classes: ileocolic, juxtaintestinal mesenteric, and central superior group" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Lama4tm1Ktry/Lama4tm1Ktry,Lama5tm2Jhm/Lama5tm2Jhm,Tg(ACTA1-cre)1Mll/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008566 increased interferon-gamma secretion "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: Lama4tm1Ktry/Lama4tm1Ktry,Lama5tm2Jhm/Lama5tm2Jhm,Tg(ACTA1-cre)1Mll/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008699 increased interleukin-4 secretion "increase in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
Show

Allelic Composition: Lama4tm1Ktry/Lama4tm1Ktry,Lama5tm2Jhm/Lama5tm2Jhm,Tg(ACTA1-cre)1Mll/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008894 abnormal intraepithelial T cell morphology "any structural anomaly of a T cell present in columnar epithelia such as in the gastrointestinal tract; intraepithelial T cells often have distinct developmental pathways and activation requirements" [ISBN:0781735149]
Show

Allelic Composition: Lama4tm1Ktry/Lama4tm1Ktry,Lama5tm2Jhm/Lama5tm2Jhm,Tg(ACTA1-cre)1Mll/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008895 abnormal intraepithelial T cell number "reduced number of T cell present in columnar epithelia such as in the gastrointestinal tract; intraepithelial T cells often have distinct developmental pathways and activation requirements" [ISBN:0781735149]
Show

Allelic Composition: Lama4tm1Ktry/Lama4tm1Ktry,Lama5tm2Jhm/Lama5tm2Jhm,Tg(ACTA1-cre)1Mll/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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