ENSGALG00000005332


Gallus gallus

Features
Gene ID: ENSGALG00000005332
  
Biological name :CACNA1D
  
Synonyms : CACNA1D / O73700 / Voltage-dependent L-type calcium channel subunit alpha-1D
  
Possible biological names infered from orthology : calcium voltage-gated channel subunit alpha1 D / Q01668 / Q99246
  
Species: Gallus gallus
  
Chr. number: 12
Strand: 1
Band:
Gene start: 7053449
Gene end: 7219032
  
Corresponding Affymetrix probe sets: Gga.528.1.S1_at (Chicken Array)   Gga.529.1.S1_at (Chicken Array)   Gga.530.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000043479
Ensembl peptide - ENSGALP00000057879
Ensembl peptide - ENSGALP00000043621
Ensembl peptide - ENSGALP00000035486
NCBI entrez gene - 395895     See in Manteia.
RefSeq - XM_015293005
RefSeq - XM_015292999
RefSeq - XM_015293000
RefSeq - XM_015293001
RefSeq - XM_015293002
RefSeq - XM_015293003
RefSeq - XM_015293004
RefSeq - NM_205034
RefSeq - XM_015292975
RefSeq - XM_015292976
RefSeq - XM_015292977
RefSeq - XM_015292978
RefSeq - XM_015292979
RefSeq - XM_015292980
RefSeq - XM_015292981
RefSeq - XM_015292982
RefSeq - XM_015292983
RefSeq - XM_015292984
RefSeq - XM_015292985
RefSeq - XM_015292986
RefSeq - XM_015292987
RefSeq - XM_015292988
RefSeq - XM_015292989
RefSeq - XM_015292990
RefSeq - XM_015292991
RefSeq - XM_015292992
RefSeq - XM_015292993
RefSeq - XM_015292994
RefSeq - XM_015292995
RefSeq - XM_015292996
RefSeq - XM_015292997
RefSeq - XM_015292998
RefSeq Peptide - NP_990365
swissprot - A0A1D5PY30
swissprot - A0A1D5NTG6
swissprot - F1N8C9
swissprot - A0A1D5NT27
swissprot - O73700
Ensembl - ENSGALG00000005332
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cacna1daENSDARG00000102773Danio rerio
 cacna1dbENSDARG00000115603Danio rerio
 cacna1dbENSDARG00000110642Danio rerio
 Q01668ENSG00000157388Homo sapiens
 Q99246ENSMUSG00000015968Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CACNA1C / calcium voltage-gated channel subunit alpha1 C / Q01815* / Q13936* / Voltage-dependent L-type calcium channel subunit alpha-1C *ENSGALG0000001302264
CACNA1S / voltage-dependent L-type calcium channel subunit alpha-1S isoform 1 / Q13698* / calcium voltage-gated channel subunit alpha1 S*ENSGALG0000003774455
CACNA1B / voltage-dependent N-type calcium channel subunit alpha-1B / O55017* / Q00975* / calcium voltage-gated channel subunit alpha1 B*ENSGALG0000000845638
CACNA1E / calcium voltage-gated channel subunit alpha1 E / Q15878*ENSGALG0000000383336
NALCN / sodium leak channel, non-selective / Q8IZF0*ENSGALG0000001686817


Protein motifs (from Interpro)
Interpro ID Name
 IPR002077  Voltage-dependent calcium channel, alpha-1 subunit
 IPR005446  Voltage-dependent calcium channel, L-type, alpha-1 subunit
 IPR005452  Voltage-dependent calcium channel, L-type, alpha-1D subunit
 IPR005821  Ion transport domain
 IPR014873  Voltage-dependent calcium channel, alpha-1 subunit, IQ domain
 IPR027359  Voltage-dependent channel domain superfamily
 IPR031649  Voltage-dependent L-type calcium channel, IQ-associated domain
 IPR031688  Voltage-gated calcium channel subunit alpha, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006816 calcium ion transport IEA
 biological_processGO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007605 sensory perception of sound IEA
 biological_processGO:0034765 regulation of ion transmembrane transport IEA
 biological_processGO:0051928 positive regulation of calcium ion transport IEA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0060372 regulation of atrial cardiac muscle cell membrane repolarization IEA
 biological_processGO:0070509 calcium ion import IEA
 biological_processGO:0070588 calcium ion transmembrane transport IEA
 biological_processGO:0086002 cardiac muscle cell action potential involved in contraction IEA
 biological_processGO:0086010 membrane depolarization during action potential IBA
 biological_processGO:0086046 membrane depolarization during SA node cell action potential IEA
 biological_processGO:0086091 regulation of heart rate by cardiac conduction IEA
 biological_processGO:1901016 regulation of potassium ion transmembrane transporter activity IEA
 biological_processGO:1901379 regulation of potassium ion transmembrane transport IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005891 voltage-gated calcium channel complex IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030018 Z disc IEA
 cellular_componentGO:1990454 L-type voltage-gated calcium channel complex IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005244 voltage-gated ion channel activity IEA
 molecular_functionGO:0005245 voltage-gated calcium channel activity IEA
 molecular_functionGO:0005262 calcium channel activity IEA
 molecular_functionGO:0008331 high voltage-gated calcium channel activity IEA
 molecular_functionGO:0030506 ankyrin binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051393 alpha-actinin binding IEA
 molecular_functionGO:0086059 voltage-gated calcium channel activity involved SA node cell action potential IEA


Pathways (from Reactome)
Pathway description
Regulation of insulin secretion
Phase 0 - rapid depolarisation
Phase 2 - plateau phase


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000008591 CACNB2 / calcium voltage-gated channel auxiliary subunit beta 2 / Q08289* / Q8CC27* / Voltage-dependent L-type calcium channel subunit beta-2 *  / complex
 ENSGALG00000005332 O73700 / CACNA1D / Voltage-dependent L-type calcium channel subunit alpha-1D / Q01668* / Q99246* / calcium voltage-gated channel subunit alpha1 D*  / complex






 

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