ENSMUSG00000000276


Mus musculus

Features
Gene ID: ENSMUSG00000000276
  
Biological name :Dgke
  
Synonyms : Dgke / Diacylglycerol kinase epsilon / Q9R1C6
  
Possible biological names infered from orthology : P52429
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: C
Gene start: 89035179
Gene end: 89066850
  
Corresponding Affymetrix probe sets: 10389738 (MoGene1.0st)   1423000_a_at (Mouse Genome 430 2.0 Array)   1436547_at (Mouse Genome 430 2.0 Array)   1438078_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000000285
Ensembl peptide - ENSMUSP00000103526
Ensembl peptide - ENSMUSP00000116277
NCBI entrez gene - 56077     See in Manteia.
MGI - MGI:1889276
RefSeq - NM_019505
RefSeq - XM_011249151
RefSeq Peptide - NP_062378
swissprot - F2Z490
swissprot - Q9R1C6
Ensembl - ENSMUSG00000000276
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dgkeENSDARG00000104793Danio rerio
 DGKEENSGALG00000003131Gallus gallus
 DGKEENSG00000153933Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dgkk / diacylglycerol kinase kappa / Q5KSL6*ENSMUSG0000006239334
Dgkg / Q91WG7 / Diacylglycerol kinase gamma / P49619*ENSMUSG0000002286133
Dgkh / diacylglycerol kinase eta / Q86XP1*ENSMUSG0000003473133
Dgkb / Q6NS52 / Diacylglycerol kinase beta / Q9Y6T7*ENSMUSG0000003609533
Dgkd / diacylglycerol kinase delta / Q16760*ENSMUSG0000007073832
Dgkq / Q6P5E8 / Diacylglycerol kinase theta / P52824*ENSMUSG0000000481532
Dgka / O88673 / Mus musculus diacylglycerol kinase, alpha (Dgka), transcript variant 2, mRNA. / P23743* / diacylglycerol kinase alpha*ENSMUSG0000002535731
Dgkz / Q80UP3 / Diacylglycerol kinase zeta / Q13574*ENSMUSG0000004047930
Dgki / diacylglycerol kinase iota isoform 2 / O75912* / diacylglycerol kinase iota*ENSMUSG0000003866529


Protein motifs (from Interpro)
Interpro ID Name
 IPR000756  Diacylglycerol kinase, accessory domain
 IPR001206  Diacylglycerol kinase, catalytic domain
 IPR002219  Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
 IPR016064  NAD kinase/diacylglycerol kinase-like domain superfamily
 IPR017438  Inorganic polyphosphate/ATP-NAD kinase, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0046834 lipid phosphorylation ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0016020 membrane ISO
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003951 NAD+ kinase activity IEA
 molecular_functionGO:0004143 diacylglycerol kinase activity ISO
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity ISO
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Effects of PIP2 hydrolysis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001473 reduced long term potentiation "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3]
Show

Allelic Composition: Adam15tm1Bbl/Adam15tm1Bbl
Genetic Background: B6.129X1-Adam15tm1Bbl

 MP:0002826 tonic seizures "increased number or decreased threshold for the induction of a seizure characterized by muscle rigidity" [hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Adam15tm1Bbl/Adam15tm1Bbl
Genetic Background: B6.129X1-Adam15tm1Bbl

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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