ENSMUSG00000025357


Mus musculus

Features
Gene ID: ENSMUSG00000025357
  
Biological name :Dgka
  
Synonyms : Dgka / Mus musculus diacylglycerol kinase, alpha (Dgka), transcript variant 2, mRNA. / O88673
  
Possible biological names infered from orthology : diacylglycerol kinase alpha / P23743
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: D3
Gene start: 128720134
Gene end: 128744855
  
Corresponding Affymetrix probe sets: 10373542 (MoGene1.0st)   1418578_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000026414
Ensembl peptide - ENSMUSP00000152021
NCBI entrez gene - 13139     See in Manteia.
MGI - MGI:102952
RefSeq - XM_017313789
RefSeq - NM_001358745
RefSeq - NM_001358746
RefSeq - NM_016811
RefSeq - XM_011243359
RefSeq - XM_011243360
RefSeq - XM_017313786
RefSeq - XM_017313787
RefSeq - XM_017313788
RefSeq - XM_006513192
RefSeq - XM_011243351
RefSeq - XM_011243353
RefSeq - XM_011243354
RefSeq - XM_011243355
RefSeq - XM_011243356
RefSeq - XM_011243357
RefSeq - XM_011243358
RefSeq Peptide - NP_001345675
RefSeq Peptide - NP_058091
RefSeq Peptide - NP_001345674
swissprot - O88673
swissprot - R4I5B2
Ensembl - ENSMUSG00000025357
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dgkaaENSDARG00000060626Danio rerio
 dgkabENSDARG00000098175Danio rerio
 DGKAENSGALG00000038110Gallus gallus
 DGKAENSG00000065357Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dgkb / Q6NS52 / Diacylglycerol kinase beta / Q9Y6T7*ENSMUSG0000003609558
Dgkg / Q91WG7 / Diacylglycerol kinase gamma / P49619*ENSMUSG0000002286154
Dgkh / diacylglycerol kinase eta / Q86XP1*ENSMUSG0000003473129
Dgkd / diacylglycerol kinase delta / Q16760*ENSMUSG0000007073829
Dgkk / diacylglycerol kinase kappa / Q5KSL6*ENSMUSG0000006239328
Dgkq / Q6P5E8 / Diacylglycerol kinase theta / P52824*ENSMUSG0000000481527
Dgki / diacylglycerol kinase iota isoform 2 / O75912* / diacylglycerol kinase iota*ENSMUSG0000003866526
Dgkz / Q80UP3 / Diacylglycerol kinase zeta / Q13574*ENSMUSG0000004047926
Dgke / Q9R1C6 / Diacylglycerol kinase epsilon / P52429*ENSMUSG0000000027624


Protein motifs (from Interpro)
Interpro ID Name
 IPR000756  Diacylglycerol kinase, accessory domain
 IPR001206  Diacylglycerol kinase, catalytic domain
 IPR002048  EF-hand domain
 IPR002219  Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
 IPR011992  EF-hand domain pair
 IPR016064  NAD kinase/diacylglycerol kinase-like domain superfamily
 IPR017438  Inorganic polyphosphate/ATP-NAD kinase, N-terminal
 IPR018247  EF-Hand 1, calcium-binding site
 IPR029477  Diacylglycerol kinase type I, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006654 phosphatidic acid biosynthetic process IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0046339 diacylglycerol metabolic process IEA
 biological_processGO:0046486 glycerolipid metabolic process IEA
 biological_processGO:0046834 lipid phosphorylation IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005886 plasma membrane IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003951 NAD+ kinase activity IEA
 molecular_functionGO:0004143 diacylglycerol kinase activity IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0005543 phospholipid binding IDA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Effects of PIP2 hydrolysis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Cks2TgTn(sb-cHS4,Tyr)2525F-2Ove/Cks2TgTn(sb-cHS4,Tyr)2525F-2Ove
Genetic Background: FVB/N-Cks2TgTn(sb-cHS4,Tyr)2525F-2Ove

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ptk2tm1Lfr/Ptk2tm1Lfr,Tg(Tek-cre)1Rwng/0
Genetic Background: involves: 129X1/SvJ * FVB/N

 MP:0003850 abnormal thymocyte activation/response "anomaly in the process of producing activated thymocytes from naive thymocytes" [mberry:Melissa Berry, Genetics Resources Curator]
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Allelic Composition: Ptk2tm1Lfr/Ptk2tm1Lfr,Tg(Tek-cre)1Rwng/0
Genetic Background: involves: 129X1/SvJ * FVB/N

 MP:0005004 clonal anergy "unresponsiveness to an antigen " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Ptk2tm1Lfr/Ptk2tm1Lfr,Tg(Tek-cre)1Rwng/0
Genetic Background: involves: 129X1/SvJ * FVB/N

 MP:0005015 increased T cell number "greater than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptk2tm1Lfr/Ptk2tm1Lfr,Tg(Tek-cre)1Rwng/0
Genetic Background: involves: 129X1/SvJ * FVB/N

 MP:0008687 increased interleukin-2 secretion "increase in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
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Allelic Composition: Ptk2tm1Lfr/Ptk2tm1Lfr,Tg(Tek-cre)1Rwng/0
Genetic Background: involves: 129X1/SvJ * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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