ENSMUSG00000036095


Mus musculus

Features
Gene ID: ENSMUSG00000036095
  
Biological name :Dgkb
  
Synonyms : Dgkb / Diacylglycerol kinase beta / Q6NS52
  
Possible biological names infered from orthology : Q9Y6T7
  
Species: Mus musculus
  
Chr. number: 12
Strand: 1
Band: A3
Gene start: 37817726
Gene end: 38634239
  
Corresponding Affymetrix probe sets: 10395428 (MoGene1.0st)   1440901_at (Mouse Genome 430 2.0 Array)   1442860_at (Mouse Genome 430 2.0 Array)   1455361_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000037900
Ensembl peptide - ENSMUSP00000152378
Ensembl peptide - ENSMUSP00000152446
Ensembl peptide - ENSMUSP00000152460
NCBI entrez gene - 217480     See in Manteia.
MGI - MGI:2442474
RefSeq - XM_017315019
RefSeq - NM_178681
RefSeq - XM_006515069
RefSeq - XM_006515070
RefSeq - XM_006515071
RefSeq - XM_006515072
RefSeq - XM_006515067
RefSeq - XM_006515068
RefSeq Peptide - NP_848796
swissprot - Q3TSN3
swissprot - Q6NS52
swissprot - A0A1Y7VLG5
Ensembl - ENSMUSG00000036095
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dgkbENSDARG00000027724Danio rerio
 DGKBENSGALG00000033561Gallus gallus
 DGKBENSG00000136267Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dgkg / Q91WG7 / Diacylglycerol kinase gamma / P49619*ENSMUSG0000002286162
Dgka / O88673 / Mus musculus diacylglycerol kinase, alpha (Dgka), transcript variant 2, mRNA. / P23743* / diacylglycerol kinase alpha*ENSMUSG0000002535753
Dgkd / diacylglycerol kinase delta / Q16760*ENSMUSG0000007073829
Dgkh / diacylglycerol kinase eta / Q86XP1*ENSMUSG0000003473128
Dgkq / Q6P5E8 / Diacylglycerol kinase theta / P52824*ENSMUSG0000000481527
Dgkk / diacylglycerol kinase kappa / Q5KSL6*ENSMUSG0000006239326
Dgkz / Q80UP3 / Diacylglycerol kinase zeta / Q13574*ENSMUSG0000004047925
Dgki / diacylglycerol kinase iota isoform 2 / O75912* / diacylglycerol kinase iota*ENSMUSG0000003866525
Dgke / Q9R1C6 / Diacylglycerol kinase epsilon / P52429*ENSMUSG0000000027623


Protein motifs (from Interpro)
Interpro ID Name
 IPR000756  Diacylglycerol kinase, accessory domain
 IPR001206  Diacylglycerol kinase, catalytic domain
 IPR002048  EF-hand domain
 IPR002219  Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
 IPR011992  EF-hand domain pair
 IPR016064  NAD kinase/diacylglycerol kinase-like domain superfamily
 IPR017438  Inorganic polyphosphate/ATP-NAD kinase, N-terminal
 IPR018247  EF-Hand 1, calcium-binding site
 IPR029477  Diacylglycerol kinase type I, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0046486 glycerolipid metabolic process IEA
 biological_processGO:0046834 lipid phosphorylation IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005886 plasma membrane ISO
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003951 NAD+ kinase activity IEA
 molecular_functionGO:0004143 diacylglycerol kinase activity ISO
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Effects of PIP2 hydrolysis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Mbnl1tm1Sws/Mbnl1tm1Sws,Mbnl2tm1Sws/Mbnl2tm1Sws,Tg(Myog-cre)1Eno/0
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ * C57BL

 MP:0001473 reduced long term potentiation "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3]
Show

Allelic Composition: Bmpr1bTn(sb-lacZ,GFP)IR3.1Jtak/Bmpr1bTn(sb-lacZ,GFP)IR3.1Jtak
Genetic Background: involves: C3H * C57BL/6 * DBA/2 * ICR

 MP:0001547 abnormal lipid level "anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Bmpr1bTn(sb-lacZ,GFP)IR3.1Jtak/Bmpr1bTn(sb-lacZ,GFP)IR3.1Jtak
Genetic Background: involves: C3H * C57BL/6 * DBA/2 * ICR

 MP:0002574 increased vertical activity "greater than average time spent jumping or rearing " [J:72576, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mbnl1tm1Sws/Mbnl1tm1Sws,Mbnl2tm1Sws/Mbnl2tm1Sws,Tg(Myog-cre)1Eno/0
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ * C57BL

 MP:0003461 abnormal response to novel object "altered investigative behavior from controls in reactions associated with exposing an animal to a novel object" [CFG:Center for Functional Genomics, Northwestern University]
Show

Allelic Composition: Mbnl1tm1Sws/Mbnl1tm1Sws,Mbnl2tm1Sws/Mbnl2tm1Sws,Tg(Myog-cre)1Eno/0
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ * C57BL

 MP:0008428 abnormal spatial working memory "anomaly in the ability to spontaneously process spatial location information in order to naviagate or perform other behavior using such locational cues, without previous encounters or training at that location" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bmpr1bTn(sb-lacZ,GFP)IR3.1Jtak/Bmpr1bTn(sb-lacZ,GFP)IR3.1Jtak
Genetic Background: involves: C3H * C57BL/6 * DBA/2 * ICR

 MP:0008432 abnormal long-term spatial reference memory "anomaly in long-term memory for spatial location information that is consolidated over hours and days after training or an encounter at that location" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bmpr1bTn(sb-lacZ,GFP)IR3.1Jtak/Bmpr1bTn(sb-lacZ,GFP)IR3.1Jtak
Genetic Background: involves: C3H * C57BL/6 * DBA/2 * ICR

 MP:0009538 abnormal synapse morphology "any strucutral anomaly of the membrane junction site of a nerve cell to a target cell, such as another nerve cell, an effector cell, or a sensory receptor cell; transmission of nerve impulses may be mediated by chemical or by electrical means" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A08.850]
Show

Allelic Composition: Bmpr1bTn(sb-lacZ,GFP)IR3.1Jtak/Bmpr1bTn(sb-lacZ,GFP)IR3.1Jtak
Genetic Background: involves: C3H * C57BL/6 * DBA/2 * ICR

 MP:0009747 impaired behavioral response to xenobiotic "decreased sensitivity to a foreign compound capable of inducing the appearance of behavioral response, such as consumption preference, induced hyperactivity or stereotypic behavior, or increased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mbnl1tm1Sws/Mbnl1tm1Sws,Mbnl2tm1Sws/Mbnl2tm1Sws,Tg(Myog-cre)1Eno/0
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ * C57BL

 MP:0009939 abnormal hippocampus neuron morphology 
Show

Allelic Composition: Bmpr1bTn(sb-lacZ,GFP)IR3.1Jtak/Bmpr1bTn(sb-lacZ,GFP)IR3.1Jtak
Genetic Background: involves: C3H * C57BL/6 * DBA/2 * ICR

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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