ENSG00000136267


Homo sapiens

Features
Gene ID: ENSG00000136267
  
Biological name :DGKB
  
Synonyms : DGKB / diacylglycerol kinase beta / Q9Y6T7
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: -1
Band: p21.2
Gene start: 14145049
Gene end: 14974777
  
Corresponding Affymetrix probe sets: 1553524_at (Human Genome U133 Plus 2.0 Array)   216307_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000385031
Ensembl peptide - ENSP00000384909
Ensembl peptide - ENSP00000385780
Ensembl peptide - ENSP00000405569
Ensembl peptide - ENSP00000386066
Ensembl peptide - ENSP00000382260
NCBI entrez gene - 1607     See in Manteia.
OMIM - 604070
RefSeq - XM_017011792
RefSeq - NM_145695
RefSeq - XM_005249628
RefSeq - XM_005249629
RefSeq - XM_005249630
RefSeq - XM_005249631
RefSeq - XM_011515153
RefSeq - XM_011515154
RefSeq - XM_011515156
RefSeq - XM_011515157
RefSeq - XM_011515158
RefSeq - XM_017011783
RefSeq - XM_017011784
RefSeq - XM_017011785
RefSeq - XM_017011786
RefSeq - XM_017011787
RefSeq - XM_017011788
RefSeq - XM_017011789
RefSeq - XM_017011790
RefSeq - XM_017011791
RefSeq - NM_001350705
RefSeq - NM_001350706
RefSeq - NM_001350707
RefSeq - NM_001350708
RefSeq - NM_001350709
RefSeq - NM_001350711
RefSeq - NM_001350712
RefSeq - NM_001350714
RefSeq - NM_001350715
RefSeq - NM_001350716
RefSeq - NM_001350722
RefSeq - NM_001350723
RefSeq - NM_001350724
RefSeq - NM_004080
RefSeq Peptide - NP_001337635
RefSeq Peptide - NP_001337653
RefSeq Peptide - NP_004071
RefSeq Peptide - NP_663733
RefSeq Peptide - NP_001337634
RefSeq Peptide - NP_001337636
RefSeq Peptide - NP_001337637
RefSeq Peptide - NP_001337638
RefSeq Peptide - NP_001337640
RefSeq Peptide - NP_001337641
RefSeq Peptide - NP_001337643
RefSeq Peptide - NP_001337644
RefSeq Peptide - NP_001337645
RefSeq Peptide - NP_001337651
RefSeq Peptide - NP_001337652
swissprot - B5MCD5
swissprot - C9JA18
swissprot - Q9Y6T7
swissprot - B5MBY2
Ensembl - ENSG00000136267
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dgkbENSDARG00000027724Danio rerio
 DGKBENSGALG00000033561Gallus gallus
 DgkbENSMUSG00000036095Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DGKG / P49619 / diacylglycerol kinase gammaENSG0000005886661
DGKA / P23743 / diacylglycerol kinase alphaENSG0000006535755
DGKD / Q16760 / diacylglycerol kinase deltaENSG0000007704428
DGKH / Q86XP1 / diacylglycerol kinase etaENSG0000010278028
DGKQ / P52824 / diacylglycerol kinase thetaENSG0000014521427
DGKK / Q5KSL6 / diacylglycerol kinase kappaENSG0000027458826
DGKZ / Q13574 / diacylglycerol kinase zetaENSG0000014909125
DGKI / O75912 / diacylglycerol kinase iotaENSG0000015768025
DGKE / P52429 / diacylglycerol kinase epsilonENSG0000015393324


Protein motifs (from Interpro)
Interpro ID Name
 IPR000756  Diacylglycerol kinase, accessory domain
 IPR001206  Diacylglycerol kinase, catalytic domain
 IPR002048  EF-hand domain
 IPR002219  Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
 IPR011992  EF-hand domain pair
 IPR016064  NAD kinase/diacylglycerol kinase-like domain superfamily
 IPR017438  Inorganic polyphosphate/ATP-NAD kinase, N-terminal
 IPR018247  EF-Hand 1, calcium-binding site
 IPR029477  Diacylglycerol kinase type I, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0030168 platelet activation TAS
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0046486 glycerolipid metabolic process IDA
 biological_processGO:0046834 lipid phosphorylation IDA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane TAS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003951 NAD+ kinase activity IEA
 molecular_functionGO:0004143 diacylglycerol kinase activity TAS
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Effects of PIP2 hydrolysis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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