ENSG00000149091


Homo sapiens

Features
Gene ID: ENSG00000149091
  
Biological name :DGKZ
  
Synonyms : DGKZ / diacylglycerol kinase zeta / Q13574
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: 1
Band: p11.2
Gene start: 46332905
Gene end: 46380554
  
Corresponding Affymetrix probe sets: 207556_s_at (Human Genome U133 Plus 2.0 Array)   239342_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000435435
Ensembl peptide - ENSP00000435332
Ensembl peptide - ENSP00000435763
Ensembl peptide - ENSP00000437060
Ensembl peptide - ENSP00000436291
Ensembl peptide - ENSP00000436273
Ensembl peptide - ENSP00000320340
Ensembl peptide - ENSP00000343065
Ensembl peptide - ENSP00000391021
Ensembl peptide - ENSP00000395684
Ensembl peptide - ENSP00000412178
Ensembl peptide - ENSP00000434016
Ensembl peptide - ENSP00000434719
NCBI entrez gene - 8525     See in Manteia.
OMIM - 601441
RefSeq - XM_017018457
RefSeq - NM_001199266
RefSeq - NM_001199267
RefSeq - NM_001199268
RefSeq - NM_003646
RefSeq - NM_201532
RefSeq - NM_201533
RefSeq - XM_005253181
RefSeq - XM_005253182
RefSeq - XM_006718354
RefSeq - XM_006718355
RefSeq - XM_011520422
RefSeq - XM_011520423
RefSeq - XM_017018455
RefSeq - XM_017018456
RefSeq - NM_001105540
RefSeq Peptide - NP_001186195
RefSeq Peptide - NP_001186196
RefSeq Peptide - NP_001186197
RefSeq Peptide - NP_003637
RefSeq Peptide - NP_963290
RefSeq Peptide - NP_963291
RefSeq Peptide - NP_001099010
swissprot - Q13574
swissprot - E9PNL8
swissprot - E9PKT3
swissprot - H0YDN6
swissprot - H0YEG2
swissprot - E9PK94
swissprot - E9PNZ3
Ensembl - ENSG00000149091
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dgkzaENSDARG00000014439Danio rerio
 dgkzbENSDARG00000076025Danio rerio
 DGKZENSGALG00000008380Gallus gallus
 DgkzENSMUSG00000040479Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DGKI / O75912 / diacylglycerol kinase iotaENSG0000015768054
DGKD / Q16760 / diacylglycerol kinase deltaENSG0000007704420
DGKH / Q86XP1 / diacylglycerol kinase etaENSG0000010278020
DGKG / P49619 / diacylglycerol kinase gammaENSG0000005886619
DGKK / Q5KSL6 / diacylglycerol kinase kappaENSG0000027458819
DGKB / Q9Y6T7 / diacylglycerol kinase betaENSG0000013626718
DGKQ / P52824 / diacylglycerol kinase thetaENSG0000014521418
DGKA / P23743 / diacylglycerol kinase alphaENSG0000006535718
DGKE / P52429 / diacylglycerol kinase epsilonENSG0000015393315


Protein motifs (from Interpro)
Interpro ID Name
 IPR000756  Diacylglycerol kinase, accessory domain
 IPR001206  Diacylglycerol kinase, catalytic domain
 IPR002110  Ankyrin repeat
 IPR002219  Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
 IPR016064  NAD kinase/diacylglycerol kinase-like domain superfamily
 IPR017438  Inorganic polyphosphate/ATP-NAD kinase, N-terminal
 IPR020683  Ankyrin repeat-containing domain
 IPR036770  Ankyrin repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016477 cell migration NAS
 biological_processGO:0030168 platelet activation TAS
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0046339 diacylglycerol metabolic process IDA
 biological_processGO:0046486 glycerolipid metabolic process IDA
 biological_processGO:0046834 lipid phosphorylation IDA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016607 nuclear speck IDA
 cellular_componentGO:0030027 lamellipodium IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003951 NAD+ kinase activity IEA
 molecular_functionGO:0004143 diacylglycerol kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding TAS
 molecular_functionGO:0016301 kinase activity IDA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Effects of PIP2 hydrolysis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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