ENSG00000077044


Homo sapiens

Features
Gene ID: ENSG00000077044
  
Biological name :DGKD
  
Synonyms : DGKD / diacylglycerol kinase delta / Q16760
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: 1
Band: q37.1
Gene start: 233354507
Gene end: 233472104
  
Corresponding Affymetrix probe sets: 208072_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000390970
Ensembl peptide - ENSP00000386455
Ensembl peptide - ENSP00000395530
Ensembl peptide - ENSP00000485047
Ensembl peptide - ENSP00000407938
Ensembl peptide - ENSP00000264057
NCBI entrez gene - 8527     See in Manteia.
OMIM - 601826
RefSeq - XM_017005140
RefSeq - XM_011512032
RefSeq - XM_011512033
RefSeq - XM_011512035
RefSeq - XM_011512037
RefSeq - XM_011512039
RefSeq - XM_011512040
RefSeq - XM_017005138
RefSeq - XM_017005139
RefSeq - NM_003648
RefSeq - NM_152879
RefSeq - XM_005246107
RefSeq - XM_005246108
RefSeq - XM_005246110
RefSeq - XM_011512028
RefSeq - XM_011512029
RefSeq - XM_011512030
RefSeq - XM_011512031
RefSeq Peptide - NP_003639
RefSeq Peptide - NP_690618
swissprot - H7BZR7
swissprot - H7C0L1
swissprot - C9JY42
swissprot - A0A024R495
swissprot - Q16760
swissprot - A0A096LNI6
Ensembl - ENSG00000077044
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 DGKDENSDARG00000113111Danio rerio
 DGKDENSGALG00000001730Gallus gallus
 DgkdENSMUSG00000070738Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DGKH / Q86XP1 / diacylglycerol kinase etaENSG0000010278065
DGKK / Q5KSL6 / diacylglycerol kinase kappaENSG0000027458839
DGKG / P49619 / diacylglycerol kinase gammaENSG0000005886619
DGKB / Q9Y6T7 / diacylglycerol kinase betaENSG0000013626719
DGKZ / Q13574 / diacylglycerol kinase zetaENSG0000014909118
DGKA / P23743 / diacylglycerol kinase alphaENSG0000006535718
DGKI / O75912 / diacylglycerol kinase iotaENSG0000015768018
DGKQ / P52824 / diacylglycerol kinase thetaENSG0000014521417
DGKE / P52429 / diacylglycerol kinase epsilonENSG0000015393316


Protein motifs (from Interpro)
Interpro ID Name
 IPR000756  Diacylglycerol kinase, accessory domain
 IPR001206  Diacylglycerol kinase, catalytic domain
 IPR001660  Sterile alpha motif domain
 IPR001849  Pleckstrin homology domain
 IPR002219  Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
 IPR011993  PH-like domain superfamily
 IPR013761  Sterile alpha motif/pointed domain superfamily
 IPR016064  NAD kinase/diacylglycerol kinase-like domain superfamily
 IPR017438  Inorganic polyphosphate/ATP-NAD kinase, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006897 endocytosis IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007173 epidermal growth factor receptor signaling pathway NAS
 biological_processGO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway NAS
 biological_processGO:0007275 multicellular organism development NAS
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0010033 response to organic substance IDA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016049 cell growth NAS
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0019932 second-messenger-mediated signaling NAS
 biological_processGO:0030168 platelet activation TAS
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0046339 diacylglycerol metabolic process IC
 biological_processGO:0046834 lipid phosphorylation TAS
 biological_processGO:0051260 protein homooligomerization IDA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003951 NAD+ kinase activity IEA
 molecular_functionGO:0004143 diacylglycerol kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019992 diacylglycerol binding NAS
 molecular_functionGO:0042803 protein homodimerization activity IDA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IDA


Pathways (from Reactome)
Pathway description
Effects of PIP2 hydrolysis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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