ENSG00000145214


Homo sapiens

Features
Gene ID: ENSG00000145214
  
Biological name :DGKQ
  
Synonyms : DGKQ / diacylglycerol kinase theta / P52824
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: -1
Band: p16.3
Gene start: 958887
Gene end: 986895
  
Corresponding Affymetrix probe sets: 207562_at (Human Genome U133 Plus 2.0 Array)   226605_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000425862
Ensembl peptide - ENSP00000427268
Ensembl peptide - ENSP00000273814
Ensembl peptide - ENSP00000421756
NCBI entrez gene - 1609     See in Manteia.
OMIM - 601207
RefSeq - XM_017007815
RefSeq - NM_001347
RefSeq - XM_011513411
RefSeq - XM_011513412
RefSeq - XM_011513414
RefSeq - XM_011513415
RefSeq - XM_017007814
RefSeq Peptide - NP_001338
swissprot - D6RJB4
swissprot - H0Y8Q7
swissprot - H0YA20
swissprot - A0A140VKC1
swissprot - P52824
Ensembl - ENSG00000145214
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 DGKQENSGALG00000002142Gallus gallus
 DgkqENSMUSG00000004815Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DGKG / P49619 / diacylglycerol kinase gammaENSG0000005886623
DGKB / Q9Y6T7 / diacylglycerol kinase betaENSG0000013626723
DGKD / Q16760 / diacylglycerol kinase deltaENSG0000007704422
DGKH / Q86XP1 / diacylglycerol kinase etaENSG0000010278021
DGKZ / Q13574 / diacylglycerol kinase zetaENSG0000014909121
DGKK / Q5KSL6 / diacylglycerol kinase kappaENSG0000027458821
DGKA / P23743 / diacylglycerol kinase alphaENSG0000006535721
DGKE / P52429 / diacylglycerol kinase epsilonENSG0000015393320
DGKI / O75912 / diacylglycerol kinase iotaENSG0000015768019


Protein motifs (from Interpro)
Interpro ID Name
 IPR000159  Ras-associating (RA) domain
 IPR000756  Diacylglycerol kinase, accessory domain
 IPR001206  Diacylglycerol kinase, catalytic domain
 IPR002219  Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
 IPR016064  NAD kinase/diacylglycerol kinase-like domain superfamily
 IPR017438  Inorganic polyphosphate/ATP-NAD kinase, N-terminal
 IPR020454  Diacylglycerol/phorbol-ester binding
 IPR029071  Ubiquitin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006111 regulation of gluconeogenesis IMP
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IDA
 biological_processGO:0006654 phosphatidic acid biosynthetic process IMP
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007171 activation of transmembrane receptor protein tyrosine kinase activity IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IMP
 biological_processGO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0008277 regulation of G-protein coupled receptor protein signaling pathway IDA
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0010629 negative regulation of gene expression IMP
 biological_processGO:0010801 negative regulation of peptidyl-threonine phosphorylation IGI
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IMP
 biological_processGO:0019933 cAMP-mediated signaling IMP
 biological_processGO:0030168 platelet activation TAS
 biological_processGO:0033198 response to ATP IDA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0046339 diacylglycerol metabolic process IDA
 biological_processGO:0046486 glycerolipid metabolic process IDA
 biological_processGO:0046834 lipid phosphorylation IDA
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IDA
 biological_processGO:0051591 response to cAMP IDA
 biological_processGO:0070493 thrombin-activated receptor signaling pathway IDA
 biological_processGO:0070528 protein kinase C signaling IDA
 biological_processGO:0090181 regulation of cholesterol metabolic process IMP
 biological_processGO:1903432 regulation of TORC1 signaling IMP
 biological_processGO:2000064 regulation of cortisol biosynthetic process IMP
 biological_processGO:2000182 regulation of progesterone biosynthetic process IMP
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome IDA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0012506 vesicle membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016363 nuclear matrix ISS
 cellular_componentGO:0016607 nuclear speck IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003951 NAD+ kinase activity IEA
 molecular_functionGO:0004143 diacylglycerol kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019900 kinase binding IPI
 molecular_functionGO:0030297 transmembrane receptor protein tyrosine kinase activator activity IGI
 molecular_functionGO:0033613 activating transcription factor binding IPI
 molecular_functionGO:0043274 phospholipase binding IPI
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Effects of PIP2 hydrolysis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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