ENSG00000157680


Homo sapiens

Features
Gene ID: ENSG00000157680
  
Biological name :DGKI
  
Synonyms : DGKI / diacylglycerol kinase iota / O75912
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: -1
Band: q33
Gene start: 137381037
Gene end: 137847092
  
Corresponding Affymetrix probe sets: 206806_at (Human Genome U133 Plus 2.0 Array)   240395_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000479053
Ensembl peptide - ENSP00000396078
Ensembl peptide - ENSP00000288490
Ensembl peptide - ENSP00000392161
Ensembl peptide - ENSP00000399131
NCBI entrez gene - 9162     See in Manteia.
OMIM - 604072
RefSeq - XM_017012788
RefSeq - XM_011516684
RefSeq - XM_017012780
RefSeq - XM_017012781
RefSeq - XM_017012782
RefSeq - XM_017012783
RefSeq - XM_017012784
RefSeq - XM_017012785
RefSeq - XM_017012786
RefSeq - XM_017012787
RefSeq - NM_001321708
RefSeq - NM_001321709
RefSeq - NM_001321710
RefSeq - NM_004717
RefSeq - XM_011516682
RefSeq Peptide - NP_001308638
RefSeq Peptide - NP_001308639
RefSeq Peptide - NP_004708
RefSeq Peptide - NP_001308637
swissprot - E9PFX6
swissprot - O75912
swissprot - E7EWQ4
swissprot - E7EM72
swissprot - A0A087WV00
Ensembl - ENSG00000157680
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CABZ01020835.1ENSDARG00000063578Danio rerio
 DGKIENSGALG00000012890Gallus gallus
 DgkiENSMUSG00000038665Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DGKZ / Q13574 / diacylglycerol kinase zetaENSG0000014909157
DGKH / Q86XP1 / diacylglycerol kinase etaENSG0000010278021
DGKD / Q16760 / diacylglycerol kinase deltaENSG0000007704421
DGKG / P49619 / diacylglycerol kinase gammaENSG0000005886619
DGKK / Q5KSL6 / diacylglycerol kinase kappaENSG0000027458819
DGKB / Q9Y6T7 / diacylglycerol kinase betaENSG0000013626719
DGKA / P23743 / diacylglycerol kinase alphaENSG0000006535718
DGKQ / P52824 / diacylglycerol kinase thetaENSG0000014521417
DGKE / P52429 / diacylglycerol kinase epsilonENSG0000015393315


Protein motifs (from Interpro)
Interpro ID Name
 IPR000756  Diacylglycerol kinase, accessory domain
 IPR001206  Diacylglycerol kinase, catalytic domain
 IPR002110  Ankyrin repeat
 IPR002219  Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR016064  NAD kinase/diacylglycerol kinase-like domain superfamily
 IPR017438  Inorganic polyphosphate/ATP-NAD kinase, N-terminal
 IPR020683  Ankyrin repeat-containing domain
 IPR036770  Ankyrin repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007269 neurotransmitter secretion IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0030168 platelet activation TAS
 biological_processGO:0034260 negative regulation of GTPase activity IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0043087 regulation of GTPase activity IEA
 biological_processGO:0046579 positive regulation of Ras protein signal transduction IEA
 biological_processGO:0046834 lipid phosphorylation IDA
 biological_processGO:0046959 habituation IEA
 biological_processGO:0051966 regulation of synaptic transmission, glutamatergic IEA
 biological_processGO:0060079 excitatory postsynaptic potential IEA
 biological_processGO:1900452 regulation of long term synaptic depression IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0008021 synaptic vesicle IEA
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0032045 guanyl-nucleotide exchange factor complex IEA
 cellular_componentGO:0032991 protein-containing complex IDA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043197 dendritic spine IDA
 cellular_componentGO:0043679 axon terminus IEA
 cellular_componentGO:0045202 synapse IDA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0048786 presynaptic active zone IEA
 cellular_componentGO:0060076 excitatory synapse IEA
 cellular_componentGO:0097060 synaptic membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003951 NAD+ kinase activity IEA
 molecular_functionGO:0004143 diacylglycerol kinase activity IEA
 molecular_functionGO:0005095 GTPase inhibitor activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0017016 Ras GTPase binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Effects of PIP2 hydrolysis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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