ENSMUSG00000038665


Mus musculus

Features
Gene ID: ENSMUSG00000038665
  
Biological name :Dgki
  
Synonyms : Dgki / diacylglycerol kinase iota isoform 2
  
Possible biological names infered from orthology : diacylglycerol kinase iota / O75912
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: B1
Gene start: 36846022
Gene end: 37300184
  
Corresponding Affymetrix probe sets: 10543967 (MoGene1.0st)   1439986_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000138628
Ensembl peptide - ENSMUSP00000087788
Ensembl peptide - ENSMUSP00000099071
Ensembl peptide - ENSMUSP00000138457
Ensembl peptide - ENSMUSP00000047858
NCBI entrez gene - 320127     See in Manteia.
MGI - MGI:2443430
RefSeq - XM_017321633
RefSeq - XM_017321626
RefSeq - XM_017321627
RefSeq - XM_017321628
RefSeq - XM_017321629
RefSeq - XM_017321630
RefSeq - XM_017321631
RefSeq - XM_017321632
RefSeq - NM_001081206
RefSeq - XM_006506257
RefSeq - XM_006506258
RefSeq - XM_006506259
RefSeq - XM_006506260
RefSeq - XM_011241385
RefSeq - XM_017321624
RefSeq - XM_017321625
RefSeq Peptide - NP_001074675
RefSeq Peptide - NP_001334033
swissprot - D3YWQ0
swissprot - D3Z519
swissprot - S4R2G0
swissprot - S4R215
swissprot - D3Z2W1
Ensembl - ENSMUSG00000038665
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CABZ01020835.1ENSDARG00000063578Danio rerio
 DGKIENSGALG00000012890Gallus gallus
 DGKIENSG00000157680Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dgkz / Q80UP3 / Diacylglycerol kinase zeta / Q13574*ENSMUSG0000004047956
Dgkd / diacylglycerol kinase delta / Q16760*ENSMUSG0000007073821
Dgkh / diacylglycerol kinase eta / Q86XP1*ENSMUSG0000003473120
Dgkg / Q91WG7 / Diacylglycerol kinase gamma / P49619*ENSMUSG0000002286119
Dgkk / diacylglycerol kinase kappa / Q5KSL6*ENSMUSG0000006239318
Dgkb / Q6NS52 / Diacylglycerol kinase beta / Q9Y6T7*ENSMUSG0000003609518
Dgka / O88673 / Mus musculus diacylglycerol kinase, alpha (Dgka), transcript variant 2, mRNA. / P23743* / diacylglycerol kinase alpha*ENSMUSG0000002535718
Dgkq / Q6P5E8 / Diacylglycerol kinase theta / P52824*ENSMUSG0000000481517
Dgke / Q9R1C6 / Diacylglycerol kinase epsilon / P52429*ENSMUSG0000000027615


Protein motifs (from Interpro)
Interpro ID Name
 IPR000756  Diacylglycerol kinase, accessory domain
 IPR001206  Diacylglycerol kinase, catalytic domain
 IPR002110  Ankyrin repeat
 IPR002219  Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR016064  NAD kinase/diacylglycerol kinase-like domain superfamily
 IPR017438  Inorganic polyphosphate/ATP-NAD kinase, N-terminal
 IPR020683  Ankyrin repeat-containing domain
 IPR036770  Ankyrin repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007269 neurotransmitter secretion IMP
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0034260 negative regulation of GTPase activity IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0043087 regulation of GTPase activity IMP
 biological_processGO:0046579 positive regulation of Ras protein signal transduction IMP
 biological_processGO:0046834 lipid phosphorylation ISO
 biological_processGO:0046959 habituation IMP
 biological_processGO:0051966 regulation of synaptic transmission, glutamatergic IMP
 biological_processGO:0060079 excitatory postsynaptic potential IMP
 biological_processGO:1900452 regulation of long term synaptic depression IMP
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005737 cytoplasm ISO
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0008021 synaptic vesicle ISO
 cellular_componentGO:0014069 postsynaptic density ISO
 cellular_componentGO:0032045 guanyl-nucleotide exchange factor complex IDA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0043025 neuronal cell body ISO
 cellular_componentGO:0043197 dendritic spine ISO
 cellular_componentGO:0043679 axon terminus ISO
 cellular_componentGO:0045202 synapse ISO
 cellular_componentGO:0048471 perinuclear region of cytoplasm IDA
 cellular_componentGO:0048786 presynaptic active zone ISO
 cellular_componentGO:0060076 excitatory synapse ISO
 cellular_componentGO:0097060 synaptic membrane ISO
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003951 NAD+ kinase activity IEA
 molecular_functionGO:0004143 diacylglycerol kinase activity ISO
 molecular_functionGO:0005095 GTPase inhibitor activity IMP
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0017016 Ras GTPase binding IPI


Pathways (from Reactome)
Pathway description
Effects of PIP2 hydrolysis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002053 decreased incidence of induced tumors "reduced frequency of tumor incidence induced by a carcinogen or mutagen" [J:56886]
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Allelic Composition: Pafah1b1tm1Awb/Pafah1b1+
Genetic Background: involves: 129S6/SvEvTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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